Navigation Links
Linheng Li proposes novel theory for mammalian stem cell regulation
Date:1/29/2010

Kansas City, Mo. (Jan. 29, 2010) Linheng Li, Ph.D., Investigator, together with Hans Clevers, M.D., Ph.D., Director of the Hubrecht Institute in Utrecht, Netherlands, co-authored a prospective review published today by the journal Science that proposes a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.

Adult stem cells are crucial for physiological tissue renewal and regeneration following injury. Current models assume the existence of a single quiescent (resting) population of stem cells residing in a single niche of a given tissue.

The Linheng Li Lab and others have previously reported that primitive blood-forming stem cells can be further separated into quiescent (reserved) and active (primed) sub-populations. Emerging evidence indicates that quiescent and active stem cell sub-populations also co-exist in several tissues including hair follicle, intestine, bone marrow, and potentially in the neural system in separate yet adjacent microenvironments. In the review, Dr. Li proposes that quiescent and active stem cell populations have separate but cooperative functional roles.

"Both quiescent and active stem cells co-exist in separate 'zones' in the same tissue," explained Dr. Li. "Active stem cells are the 'primed' sub-population that account for the generation of corresponding tissues, whereas quiescent stem cells function as a 'back-up' or 'reserved' sub-population, which can be activated in response to the loss of active stem cells or to tissue damage."

The new model would explain how the balance can be regulated between stem cell maintenance and simultaneous support of rapid tissue regeneration, not only at the individual cell level but also at the stem cell population level. The advantage of maintaining 'zoned' sub-populations of stem cells is to increase longevity of stem cells within organisms that have long life spans and large bodies.

The existence of two sub-populations of adult stem cells offers another advantage in the rapidly regenerating tissues in mammals by reducing the risk for mutations that cause tumors.

Intriguingly, cancers may utilize this same mechanism to maintain co-existing active-quiescent pools of stem cell sub-populations that support fast tumor growth (by active stem cells) while preserving the root of malignancy (by quiescent stem cells). This may explain the basis of drug resistance to cancer treatment.

"If this hypothesis is true, the critical question will be how to target quiescent drug-resistant cancer stem cells," said Dr. Li. "We will test this model in cancers in an effort to determine how to activate quiescent (drug-resistant) cancer stem cells for further targeting."


'/>"/>

Contact: Susan Weigel
slw@stowers.org
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
2. A study proposes a new universal rule to explain the equilibrium of plant populations
3. A study proposes a new universal rule to explain the equilibrium of plant populations
4. Study proposes new theory of how viruses may contribute to cancer
5. NOAA proposes federal regulations to protect black abalone
6. NOAA proposes rule to prevent commercial harvesting of krill
7. Baker Institute report proposes strategies to ensure global energy security
8. MGH researchers describe new way to identify, evolve novel enzymes
9. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
10. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
11. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... RESTON, Va. , Feb. 2, 2016 /PRNewswire/ ... contract award from the U.S. Army Research Office ... extend the range and sensitivity of the company,s ... DoD,s Past Accounting Mission and, more generally, defense-related ... its DNA phenotyping capabilities (predicting appearance and ancestry ...
(Date:2/1/2016)... NEW YORK , Feb. 1, 2016  Today, ... Heart Association (AHA) announced plans to develop a first ... cognitive computing power of IBM Watson. In the first ... disease, AHA, IBM (NYSE: IBM ), and Welltok ... metrics and health assessments with cognitive analytics, delivered on ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... , February 12, 2016 ... Efforts by Enabling Scientific Understanding of Complex Diseases ... Rare Diseases --> ... diagnostics in South Asia and a leading provider of ... contribute $10 million to the GenomeAsia 100K consortium ...
(Date:2/11/2016)... Germany and GERMANTOWN, ... QGEN ; Frankfurt Prime Standard: QIA) today announced ... RNA Panels for gene expression profiling, expanding QIAGEN,s portfolio ... The panels enable researchers to select from over 20,000 ... and discover interactions between genes, cellular phenotypes and disease ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... cutting-edge information focused on the development and manufacture of biopharmaceuticals and therapeutics, ... sponsor of the 2016 BioProcess International Awards – Recognizing Excellence in the ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... than 150 years, continues today to pursue the highest level of accuracy and ... instruments: the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough ...
Breaking Biology Technology: