Navigation Links
Linheng Li proposes novel theory for mammalian stem cell regulation
Date:1/29/2010

Kansas City, Mo. (Jan. 29, 2010) Linheng Li, Ph.D., Investigator, together with Hans Clevers, M.D., Ph.D., Director of the Hubrecht Institute in Utrecht, Netherlands, co-authored a prospective review published today by the journal Science that proposes a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.

Adult stem cells are crucial for physiological tissue renewal and regeneration following injury. Current models assume the existence of a single quiescent (resting) population of stem cells residing in a single niche of a given tissue.

The Linheng Li Lab and others have previously reported that primitive blood-forming stem cells can be further separated into quiescent (reserved) and active (primed) sub-populations. Emerging evidence indicates that quiescent and active stem cell sub-populations also co-exist in several tissues including hair follicle, intestine, bone marrow, and potentially in the neural system in separate yet adjacent microenvironments. In the review, Dr. Li proposes that quiescent and active stem cell populations have separate but cooperative functional roles.

"Both quiescent and active stem cells co-exist in separate 'zones' in the same tissue," explained Dr. Li. "Active stem cells are the 'primed' sub-population that account for the generation of corresponding tissues, whereas quiescent stem cells function as a 'back-up' or 'reserved' sub-population, which can be activated in response to the loss of active stem cells or to tissue damage."

The new model would explain how the balance can be regulated between stem cell maintenance and simultaneous support of rapid tissue regeneration, not only at the individual cell level but also at the stem cell population level. The advantage of maintaining 'zoned' sub-populations of stem cells is to increas
'/>"/>

Contact: Susan Weigel
slw@stowers.org
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stowers Institutes Linheng Li Lab expands understanding of bone marrow stem cell niche
2. A study proposes a new universal rule to explain the equilibrium of plant populations
3. A study proposes a new universal rule to explain the equilibrium of plant populations
4. Study proposes new theory of how viruses may contribute to cancer
5. NOAA proposes federal regulations to protect black abalone
6. NOAA proposes rule to prevent commercial harvesting of krill
7. Baker Institute report proposes strategies to ensure global energy security
8. MGH researchers describe new way to identify, evolve novel enzymes
9. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
10. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
11. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... N.Y. A sleep-promoting circuit located deep in the ... sleep. Discovered by researchers at Harvard School of Medicine ... Biomedical Sciences, this is only the second "sleep node" ... be both necessary and sufficient to produce deep sleep. ... , the study demonstrates that fully half of all ...
(Date:9/18/2014)... robotic system that can operate inside the bore of ... of a biomedical research partnership program at Brigham and ... if the robot, in conjunction with real-time MRI images, ... costly, and less discomforting for the patient. The novel ... therapies with greater precision. , Developed by a team ...
(Date:9/18/2014)... many times it,s demonstrated, it,s still hard to ... But by using a signaling system called "quorum ... to suit their population. In short, some bacteria ... act accordingly. , Once the population of quorum-sensing ... innocuous to pathogenic, or from unhelpful to helpful. ...
Breaking Biology News(10 mins):No sedative necessary: Scientists discover new 'sleep node' in the brain 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3
... of the world,s biggest killers for as long as records ... the rise, there is a renewed push to find different ... have stepped up to the plate to answer the call. ... department of chemical and biomolecular engineering, recently were awarded a ...
... Now computers are at it again, but this ... itself. An interdisciplinary team of scientists at Vanderbilt ... taken a major step toward this goal by demonstrating ... a biological system and derive the basic mathematical equations ...
... has been associated with cognitive decline, characterized by a ... thought-processing speed. But in a study of 300 post-menopausal ... in Argentina, obese participants in the study performed better ... leading researchers to speculate about the role of sex ...
Cached Biology News:UH engineers finding new ways to fight malaria with DOD grant 2Robot biologist solves complex problem from scratch 2Robot biologist solves complex problem from scratch 3Association between menopause, obesity and cognitive impairment 2
(Date:9/22/2014)... D.C (PRWEB) September 22, 2014 FierceBiotech ... top privately held biotechnology companies of 2014. FierceBiotech ... companies before selecting this year’s winners. Those selected ... biotechnology companies in the industry. , "It's ... new group of Fierce 15 companies," said Carroll. "This ...
(Date:9/22/2014)... , Sept. 22, 2014  Spherix Incorporated (SPEX) -- an ... of intellectual property, today announced that the United States Patent ... Company in the month of September that is part of ... issued patent is: USRE45,121 , Application number: US ... Filing date: Dec 27, 2012 The listed ...
(Date:9/20/2014)... 2014 HealthTronics, Inc. , ... radiology products and services, has signed a distribution ... Clinicon Corporation for its high precision laser ... minimally invasive, mobile, surgical technology—offering more choices for ... agreement, HealthTronics will make available Clinicon’s FDA-cleared SureLase™ ...
(Date:9/19/2014)... rather than electricity, to move data would consume ... a growing concern as chips, transistor counts rise. ... circuits light emitters, modulators, and detectors ... light source for optical chips is molybdenum disulfide ... as a single, atom-thick layer. Other experimental on-chip ...
Breaking Biology Technology:FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Toward optical chips 2Toward optical chips 3
... detect broken bones, tumors and dental cavities, analyze atoms in ... knew they could cause crystals to form? A team ... the formation of a new type of crystal: charged cylindrical ... which is unknown in crystals. Similar phenomena may occur naturally ...
... , , , , ... 25 /PRNewswire-Asia/ -- China,Yongxin Pharmaceuticals, Inc. (OTC Bulletin Board: ... distributor and,retailer of Chinese traditional medicines, pharmaceutical products, natural,health products, ... The Company today announced that it plans to open twenty ...
... , ... ,Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in ... important milestone in the official,marketing authorisation process for ... lipase deficiency (LPLD). The submission,of the Glybera(R) Marketing ...
Cached Biology Technology:Surprising discovery: X-rays drive formation of new crystals 2China Yongxin Pharmaceuticals Plans to Open Eighteen New Stores in 2010 to Further Expand Customer Base and Increase Market Share 2China Yongxin Pharmaceuticals Plans to Open Eighteen New Stores in 2010 to Further Expand Customer Base and Increase Market Share 3China Yongxin Pharmaceuticals Plans to Open Eighteen New Stores in 2010 to Further Expand Customer Base and Increase Market Share 4EMA Starts Formal Review of Glybera(R) Dossier 2EMA Starts Formal Review of Glybera(R) Dossier 3
Mitochondria/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
... increasing age, the autofluorescent pigment lipofuscin ... cell types, including neurons. The presence ... use of fluorescence microscopy in the ... broad excitation and emission spectra, which ...
... the family of calcium binding proteins such as ... of an alpha and beta chain whereas S100B ... protein is also expressed in the antigen presenting ... and interdigitating reticulum cells in the paracortex of ...
LEAF™ Purified anti-human/mouse/rat ICOS...
Biology Products: