Navigation Links
LincRNAs serve as genetic air-traffic controllers
Date:7/14/2009

ins first author Ahmad Khalil, PhD, a scientist in the Department of Pathology at BIDMC and the Broad Institute. "Chromatin does this through a process of compaction; by determining which areas to compact and which to leave open, chromatin successfully determines which genes are accessible for transcription."

But he adds, it has been a mystery as to how this chromatin structure is so precisely targeted by specific enzymes and not others.

"By utilizing a technology known as RIP-Chip we were able to examine RNA-protein interaction on a large scale and determine which lincRNAs are associated with each enzyme we examined," he adds. To analyze this tremendous amount of data, coauthor Mitchell Guttman, PhD, a bioinformatician at BIDMC and the Broad Institute, used a mathematical algorithm that identified which lincRNAs are bound by chromatin-modifying enzymes and which are not.

"This analysis revealed that 20 to 30 percent of lincRNAs are bound by three distinct chromatin-modifying complexes," adds Khalil. "By depleting several of these lincRNAs from cells, we were able to show a significant overlap between the genes which become affected by the depletion of lincRNAs and the depletion of the enzymes. This provided us with the evidence that these proteins work together with lincRNAs to target specific regions of the genome."

Standard "textbook" genes encode RNAs that are translated into proteins, and mammalian genomes contain about 20,000 such protein-coding genes. Some genes, however, encode functional RNAs that are never translated into proteins. These include a handful of classical examples known for decades and some recently discovered classes of tiny RNAs, such as microRNAs. By contrast, lincRNAs are thousands of bases long. Because only about 10 examples of functional RNAs were previously identified, they seemed more like genomic oddities than key players. With these latest findings, which also uncovered an additional 1,500 lin
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. LSUHSCs Bazan awarded ARRA grant to preserve vision
2. Working to conserve endangered Playboy bunnies
3. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
4. Researchers observe single protein dimers wavering between two symmetrically opposed structures
5. Scientists urge global action to preserve water supplies for billions worldwide
6. Drugs needed to preserve eggs for reproduction need to be given in stages
7. Sugar on bacteria surface serves as base for a web of resistance
8. Male impotence drugs may deserve a second look in women
9. Case Western Reserve University engineers hit pay dirt with clay mixture
10. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
11. Case Western Reserve University receives $1.66m grant from NIH for otoprotection research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... (FASEB) has released updated factsheets for fiscal ... Institutes of Health (NIH) benefits each of the 50 ... make these factsheets available to help citizens and policymakers ... FASEB President, Margaret K. Offermann, MD, PhD. NIH is ... investing $29.2 billion in FY 2013 in medical research, ...
(Date:4/22/2014)... Analyzing thousands of breeding bird surveys sent in ... Canada over 35 years, wildlife researchers report that most ... northward or toward higher elevation in response to climate ... means that most previous studies of potential climate change ... or the other have likely underestimated the effects of ...
(Date:4/22/2014)... French . , ... complete genome and subsequent phylogenetic analysis show that the ... is distinct from strains previously identified in the Democratic ... linked the laboratory confirmed cases with the initial deaths ... is a lethal, highly contagious virus for which there ...
Breaking Biology News(10 mins):Wildlife response to climate change is likely underestimated, experts warn 2Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2
... work. Biology researchers at Lewis & Clark College and ... ancient transfer of a toxin between ancestors of two ... remains as how the toxin passed between the two ... journal Bioinformatics, 22(3): 264-268, in an article titled "Lateral ...
... marijuana or its active cannabinoid ingredient alleviates symptoms ... researchers have found that the brain's natural "endocannabinoids" ... to alleviate neuronal damage. However, scientists have not ... own immune system. , Now, experiments by Oliver ...
... Research Associate at the Stowers Institute for Medical Research, ... investigator with the Howard Hughes Medical Institute, have demonstrated ... is expressed in a cyclic fashion during the formation ... embryo. , The findings, which were published in ...
Cached Biology News:Evolution mystery: Spider venom and bacteria share same toxin 2Brain's own cannabis compound protects against inflammation 2Stowers scientists demonstrate mechanism of vertebral formation 2
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal Products ... selected by Buffalo BioBlower Technologies LLC ("B3") as the ... Phase 2 award from the Army Corps of Engineers.  ... that kills all biological contaminants and destroys VOCs and ...
(Date:1/15/2014)... England and SAN JOSE, California ... international biotechnology company developing antibody-drug conjugates for cancer, today announced ... Board of Directors. Dr Reynolds has over 20 years, development ... Medical Officer at Seattle Genetics. "I am delighted ...
(Date:1/15/2014)... IPSWICH, England , January 15, 2014 ... to win races on the Formula 1 track could help ... between McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based ... funded by healthcare provider Simplyhealth. Telemetry technology, which ...
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA theory ... of these latent viruses is the Epstein Barr Virus (EBV), ... arthritis (RA) is a chronic inflammatory disease that destroys the ... that RA patients have high concentrations of EBV DNA in ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... , ... , ... series documenting,simple protocols for culturing cells in a BioFlo 110,benchtop ... impellers,and control modules to enable growth of a wide variety,of cultures, including ...
... Olive, Ph.D. , Molecular Biology Department , ... Lincoln, NE 68504 , , ... , Optical imaging is ... of a living animal. While several optical imaging modalities employing,fluorescent proteins or bioluminescent reporter ...
... , ... , , ... HPLC by utilizing the Prominence,hardware series. In this respect, we are ... while providing high,reliability and expandability not available with other fast,LC systems., ...
Cached Biology Technology:Insect Cell Culture Using a BioFlo 110 Benchtop Bioreactor 2Insect Cell Culture Using a BioFlo 110 Benchtop Bioreactor 3Insect Cell Culture Using a BioFlo 110 Benchtop Bioreactor 4Insect Cell Culture Using a BioFlo 110 Benchtop Bioreactor 5Insect Cell Culture Using a BioFlo 110 Benchtop Bioreactor 6Near Infrared Technology and Optical Agents For Molecular Imaging 2Near Infrared Technology and Optical Agents For Molecular Imaging 3Near Infrared Technology and Optical Agents For Molecular Imaging 4Near Infrared Technology and Optical Agents For Molecular Imaging 5Near Infrared Technology and Optical Agents For Molecular Imaging 6Near Infrared Technology and Optical Agents For Molecular Imaging 7Prominence UFLC 2Prominence UFLC 3Prominence UFLC 4Prominence UFLC 5Prominence UFLC 6Prominence UFLC 7Prominence UFLC 8
... White lyophilized solid. PROTECT FROM LIGHT. ... inhibitor of γ-secretase. Equipotently inhibits the release ... = 2.6 μM) and Aβ x-42 ... HEK293 cells stably transfected with the Amyloid ...
...
Corticoliberin...
Microlite 2+ Plate, round bottom; an irradiated, high binding surface with enhanced dynamic range, extra high reflectivity and minimal cross talk for low signal luminescent reactions....
Biology Products: