Navigation Links
Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
Date:9/26/2010

STANFORD, Calif. - Researchers at Stanford University were able to use light to induce normal patterns of muscle contraction, in a study involving bioengineered mice whose nerve-cell surfaces are coated with special light-sensitive proteins.

The new approach allows scientists to more accurately reproduce muscle firing order, making it a valuable research tool. The investigators, from Stanford's Schools of Medicine and of Engineering, also believe this technique could someday spawn practical applications, from restoring movement to limbs paralyzed by stroke or spinal-cord or brain injury to countering spasticity caused by cerebral palsy.

The study, to be published online Sept. 26 in Nature Medicine, employed a technology known as optogenetics, which involves the insertion of a specialized gene derived from algae into the genomes of experimental animals. This gene encodes a light-sensitive protein that situates itself on nerve-cell surfaces. Particular wavelengths of light can trigger nerve activity in animals endowed with these proteins, modifying nerve cells' firing patterns at the experimenters' will.

"Our group's focus is on restoring optimal movement for people with physical disabilities," said one of the study's two senior authors, Scott Delp, PhD, a professor of bioengineering and the Clark Professor in the School of Engineering. "With optical stimulation, we were able to reproduce the natural firing order of motor-nerve fibers - an important step forward."

Optogenetics was invented at Stanford by the study's other senior author, Karl Deisseroth, MD, PhD, associate professor of bioengineering and of psychiatry and behavioral science, who has used optogenetics in many experiments to conduct research on the central nervous system of freely moving animals. "This marks the first time the technique has been applied to the mammalian peripheral nervous system," Deisseroth said.

The peripheral nervous
'/>"/>

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. 2010 AAO-HNSF new research daily highlights: Sunday, Sept. 26, 2010
2. Researchers tap into cell power to create building skins that adapt to heat/light of environment
3. Research sheds light on altruism
4. Undergraduate research highlighted in DNA and Cell Biology Journal
5. Research aims to lighten load carried by soldiers
6. BU partners in 5-year, $7.5M grant to study animal flight
7. Connection between light at night and cancer revealed in additional study
8. Connection between light at night (LAN) and cancer revealed in additional study
9. New infrared light may open new frontier in fighting cancer, Tay Sachs
10. Light, circadian rhythms affect vast range of physiological, behavioral functions
11. New study sheds light on painkilling system in brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... 2015  Navitas today announced that it ... Submission Content Management webinar scheduled on August ... to the Implementation of Regulatory Submission Standards ... industry, vendors, health authorities, consultants and the ... a standard method of implementing electronic submission ...
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/6/2015)... REDWOOD CITY, Calif. , Aug. 6, 2015 ... (D-Silicon Valley) will visit Crossmatch ™ to ... secure networks and protect data. Crossmatch is a ... solutions whose technologies and expertise are helping federal ... operational efficiency and security.   "The ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Rep. Honda to Visit Crossmatch in Redwood City 2
... in both coconut oil and human breast milk lauric ... to a bioengineering graduate student from the UC San Diego ... system" published in the journal ACS Nano ... to skin-dwelling bacteria ( Propionibacterium acnes ) that cause common ...
... way to identify the hidden genetic material responsible for ... to a deeper understanding of how multiple genes interact ... problems. Writing in the April 15 edition of ... professor in Princeton,s Department of Ecology and Evolutionary Biology ...
... A team of scientists at the University of California, ... genes that initiate and manage cilia formation. Although scientists have ... their role in disease. This new discovery, which may lead ... 15 edition of Nature . Primary ...
Cached Biology News:Treat acne with coconut oil and nano-bombs 2Genetic patterns rise from huge yeast samples 2Genetic patterns rise from huge yeast samples 3Genetic patterns rise from huge yeast samples 4Primary cilia formation provides insight into genetic diseases 2
(Date:9/2/2015)... 2015 Research and ... of Jain PharmaBiotech,s new report "Biomarkers - ... This report follows the broad definition ... be objectively measured and evaluated as an indicator ... as pharmacological responses to a therapeutic intervention. Tests ...
(Date:9/2/2015)... CHARLOTTESVILLE, Virginia , September 2, 2015 ... sponsoring of the winners of the 2015 BeHEARD science ... Institute that offers rare disease researchers, access to the ... will use its drug repositioning and pathway analytics capability ... at Wylder Nation Foundation in the study of Niemann-Pick ...
(Date:9/2/2015)... Sept. 2, 2015 Australian prostate cancer technology ... Australian science prize recognising ,outstanding, science that uses its ... globally launch a novel prostate cancer diagnostic test known ... level consortium taking out the peer-reviewed Australian Museum Eureka ... This prize is awarded for ground ...
(Date:9/2/2015)... TEL-AVIV, Israel , September 2, 2015 /PRNewswire/ ... BLGTY, TASE: BOLT) ("BioLight" or the "Company"), a ... innovations in ophthalmology and cancer diagnostics, announced today ... treatment of glaucoma will be delivered at the ... of the European Society of Cataract & Refractive ...
Breaking Biology Technology:Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3
... High Quality Digital Imaging Solution Now Available in ... Medical Systems, a leading supplier of digital radiography ... and practice management software (VIA(R)), will showcase its ... RapidStudy(TM) DR imaging solutions at the annual Central ...
... April 22 GeneGo, Inc., a leading provider of ... analysis , today announced that the University of Cardiff ... University researchers will have access to GeneGo,s MetaCore, training ... leverage their partner relationship with GeneGo to provide a ...
... The PharmSource ADVANTAGE online service has added two new capabilities ... providers. , ... Fairfax, Virginia (PRWEB) ... provider of business intelligence on contract drug development and manufacture, ...
Cached Biology Technology:Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 2Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 3Cardiff University Becomes a GeneGo Center of Excellence 2PharmSource Adds New Capabilities to the PharmSource ADVANTAGE Online Service 2
Assay Diluent, 10 L...
... Clone/PAD: ZMD.474. Immunogen: Synthetic peptide ... the mouse junctophilin-3. Specificity: Specific ... junctophilin-3 protein. Reactivity: Mouse (positive ... hippocampus and heart tissues). Applications: ...
...
... Cloning Kit, 40 reactions. Optimized for ... all PCR products with blunt or ... by offering consistently better signal-to-noise ratios ... positive clones.Amplicons generated by proof-reading thermostable ...
Biology Products: