Navigation Links
Light activated 'warhead' turns modest molecules into super protein killers
Date:3/14/2010

oor efficiency, largely due to self-inactivation. The new warhead used by the Scripps Florida team represents a significant advance.

They used a derivative of ruthenium, a metallic element that produces what is known as singlet oxygen, the well known oxygen molecule, O2.

"When the ruthenium absorbs visible light," Kodadek said, "it has to dump that energy to return to a normal state. In the process, it produces an extremely reactive form of oxygen that rips apart whatever proteins it happens to encounter. Basically, it destroys those proteins forever."

While there have been reports of other "warhead"-carrying peptoids, the study said, the ruthenium derivative used by Kodadek and his colleagues is an important technical advance, one that allows scientists to target both extracellular and intracellular protein targets. Unlike organic singlet oxygen generators, the Ru complex is itself insensitive to singlet oxygen, greatly increasing the efficiency of CALI.

The other important point, the study noted, is that these new peptoids have no effect on any cellular components until they are activated by light.

Simple synthetic compounds like peptoids have many advantages over other ligands molecules that bind to proteins and alter their function such as antibodies, Kodadek pointed out. They can be modified easily for attachment to surfaces and can be produced relatively quickly in large amounts a multi-million member peptoid library, for example, can be created in about three days.

This makes them ideal building tools for biomedical research, the study said.

Kodadek became interested in developing this new technique when he and Benjamin Cravatt, chair of the Scripps Research Department of Chemical Physiology, decided to combine separate technologies a peptoid library synthesis and screening platform developed in the Kodadek laboratory in Florida and activity-based protein profiling (ABPP) developed in Cra
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Clemson scientists shed light on molecules in living cells
2. September Geology and GSA Today media highlights
3. Highlights from the September 2007 Journal of the American Dietetic Association
4. Genome study shines light on genetic link to height
5. Pig study sheds new light on the colonisation of Europe by early farmers
6. Researchers developing device to predict proper light exposure for human health
7. AGU journal highlights -- Sept. 6, 2007
8. IDEMA Reveals Program Highlights for DISKCON USA 2007
9. Men shed light on the mystery of human longevity, study finds
10. Zebrafish to shed light on human mitochondrial diseases
11. UT researcher sheds new light on hybrid animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... improve students, chances of completing introductory biology courses ... (UH) implemented a comprehensive student success program, employing ... , Through a grant from the Texas ... Biology and Biochemistry embarked on a pilot program ... non-majors and "Introductory Biology" for science majors. These ...
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
(Date:8/19/2014)... lemur. It,s not an African Bush Baby or even a ... downright "cool" primate from Southeast Asia. , "It,s really not ... Brown, curator-in-charge at the University of Kansas, Biodiversity Institute. "A ... body; a long tail with a furry tuft at the ... a bit like the disks on the digits of tree ...
Breaking Biology News(10 mins):University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3
... of breast cancer patients have tumours that show rapid ... in all of these cases is the presence of ... membranes. Consequently, these aggressive tumours are referred to as ... IRB Barcelona headed by ICREA researcher Roger Gomis, have ...
... , This release is available in ... unsightly vegetable patches, they can also result in extensive ... this garden pest are similar to those involved in ... Breeding Research in Cologne and the University of Zurich ...
... experts from the European Society on Clinical and ... the International Osteoporosis Foundation (IOF) have published a ... femoral (upper thigh bone) fractures and long-term treatment ... common drug therapy for osteoporotic fracture prevention, prescribed ...
Cached Biology News:The most aggressive forms of breast cancer elude cellular control mechanisms in order to expand 2Mildew-resistant and infertile 2IOF and ESCEO position on atypical femoral fractures and long-term bisphosphonate use 2
(Date:8/19/2014)... , Aug. 19, 2014 ... addition of the "Spectroscopy Equipment and ... report to their offering. ... Spectroscopy Equipment and Accessories in US$ Thousands ... (UV-Vis spectrophotometers, Raman Spectrometers, NMR-EPR Spectrometers, Near ...
(Date:8/19/2014)... VANCOUVER , Aug. 19, 2014 /PRNewswire/ - iCo ... (OTCQX: ICOTF), today reported results of its Oral ... latent HIV reservoirs.  The study, conducted by ImmuneCarta®, ... in vitro effectiveness of Oral Amp ... remain present in individuals despite intensive treatment with ...
(Date:8/18/2014)... 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD), a life ... products for advanced microarray diagnostics, today announced it will ... at 2:00 pm ET.  During the ... brief review of SQI,s recent commercialization progress and then ... veteran recently appointed to the Board of Directors of ...
(Date:8/18/2014)... Global HIV Infection Drug Market and ... Reportstack. The rate of HIV infection and the number of ... at a positive rate across the globe. It has been ... 2005 to 1.5 in 2013, with the rates for children ... changes in the infection rates has been the improved access ...
Breaking Biology Technology:Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 2SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4
... Electric Power Co. and Wisconsin Gas LLC, collectively known ... for relationship management software to automate, track and execute ... than 1.1 million electric customers in Wisconsin and Michigan's ... customers in Wisconsin. As part of a sourcing transformation, ...
... MILWAUKEE - Niceware International, a supplier ... on Monday they have introduced version 4.0 of their ... include support for reading and programming radio frequency identification ... The system's modules are also integrated with Windows programs ...
... services provider, announced Tuesday a new market campaign in ... the campaign will expand the PDS presence in the ... Specialized Technology Partner Certifications from Cisco in the three ... Communications, IP Communications Express, and Wireless. In addition, PDS ...
Cached Biology Technology:
Normal human serum, single donor...
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
Human IL-17D Affinity Purified Polyclonal Ab...
BBS/Glycerol/Casein Block and Diluent - 10X Concentrate, 1 L...
Biology Products: