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Light-activated neurons from stem cells restore function to paralyzed muscles
Date:4/4/2014

cific muscles following paralysing neurological injuries or disease," explains Professor Greensmith. "Within the next five years or so, we hope to undertake the steps that are necessary to take this ground-breaking approach into human trials, potentially to develop treatments for patients with motor neuron disease, many of whom eventually lose the ability to breathe, as their diaphragm muscles gradually become paralysed. We eventually hope to use our method to create a sort of optical pacemaker for the diaphragm to keep these patients breathing."

The light-responsive motor neurons that made the technique possible were created from stem cells by Dr Ivo Lieberam of the MRC Centre for Developmental Neurobiology, King's College London.

"We custom-tailored embryonic stem cells so that motor neurons derived from them can function as part of the muscle pacemaker device." says Dr Lieberam, who co-led the study. "First, we equipped the cells with a molecular light sensor. This enables us to control motor neurons with blue light flashes. We then built a survival gene into them, which helps the stem-cell motor neurons to stay alive when they are transplanted inside the injured nerve and allows them to grow to connect to muscle."


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Contact: Harry Dayantis
h.dayantis@ucl.ac.uk
44-020-310-83844
University College London
Source:Eurekalert

Page: 1 2

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