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Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
Date:4/7/2013

transgenic mice depleted their muscles' supplies of glycogen very quickly," Lin said.

After some follow-up experiments to figure out exactly which molecules were controlled by BAF60c, Lin and his team were confident that they had identified major players responsible for promoting white muscle formation. Now that they knew how to make more white muscle in animals, they wanted to determine whether white muscle was a deleterious or an adaptive characteristic of diabetes.

The team induced obesity in mice by feeding them the "Super Size Me" diet, Lin said. On a high-fat diet, a mouse will double its body weight in two to three months. They found that obese mice with BAF60c transgene were much better at controlling blood glucose.

"The results are a bit of a surprise to many people," Lin said. "It really points to the complexity in thinking about muscle metabolism and diabetes."

In humans, resistance training promotes the growth of white muscle and helps in lowering blood glucose. If future studies in humans determine that the BAF60c pathway is indeed the way in which cells form white muscle and in turn optimize metabolic function, the finding could lead to researching the pathway as a drug target.

"We know that this molecular pathway also works in human cells. The real challenge is to find a way to target these factors," Lin said.


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Contact: Laura J. Williams
laurajw@umich.edu
734-615-4862
University of Michigan
Source:Eurekalert

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