Navigation Links
Lifestyle, age linked to diabetes-related protein
Date:9/18/2013

PROVIDENCE, R.I. [Brown University] Over the last decade researchers have amassed increasing evidence that relatively low levels of a protein called sex hormone binding globulin (SHBG) can indicate an elevated risk of type 2 diabetes and metabolic syndrome years in advance.

In a collection of studies described in a new paper, published online Sept. 18 in the journal Clinical Chemistry, Dr. Simin Liu, professor of epidemiology and medicine at Brown, led an effort to measure SHBG levels in 13,547 women who take part of the national Women's Health Initiative. The team comprehensively investigated nongenetic factors associated with levels of the protein. The researchers found that age, use of estrogen replacement therapy, physical activity, and caffeinated coffee drinking were significantly higher with higher SHBG levels. On the other hand, a high body-mass index (BMI) correlated with low SHBG levels.

Liu's group had previously established that SHBG can predict type 2 diabetes risk and identified several mutations in the genetic coding for the protein that are also predictive.

"Even though there are genetic influences, this protein doesn't necessarily stay unchanged in each of us throughout our lives," Liu said. "This protein seems to capture the cumulative effect between the gene and our environment in reflecting a metabolic state of our body, particularly in the liver, ultimately affecting diabetes risk."

The researchers also made another important finding: SHBG's significant associations in women did not vary by ethnic group.

"This is the largest study conducted to date that shows that ethnic-specific differences concerning SHBG levels if any are not significant enough to warrant an ethnic specific reference for potential clinical application of this protein for diabetes risk stratification," said Dr. Atsushi Goto, first author and an endocrinologist at the Japanese Diabetes Research Center of the National Center for Global Health and Medicine in Tokyo.

That research outcome extends the results of a study that the team published last year in the journal. That study reported that SHBG predicted type 2 diabetes risk among black, Hispanic, and Asian or Pacific islander postmenopausal women. Previously it had only been shown in white men and women.

Informative indicators

There are several reasons why tracking demographic and lifestyle associations with SHBG levels is important, Liu said. For one, they give doctors who want to assess type 2 diabetes risk or metabolic syndrome a basic frame of reference on what levels of SHBG might exist in patients based on their lifestyle and demographics.

"How do you stratify risk for clinical and preventative interventions?" Liu said. "If you want to use this clinically, you have to establish a population reference, for instance in the sense of age or ethnicity."

The research may also help to strengthen possible strategies for intervention. Age cannot be affected, but physical activity, BMI, coffee intake, and estrogen therapy can all be adjusted. Knowing that these factors are linked to the biomarker suggests that experiments could be done to see whether changing those factors exercising more, for example could change levels of the protein over time in individuals, Liu said. That, in turn, could affect their ultimate diabetes risk.

In addition, the findings may also help explain the possible physiological connections between those factors and risk of type 2 diabetes. For example, drinking regular coffee and having a lower BMI have each independently been associated with a lower risk for the condition. The new research suggests that SHBG may have an intermediating role in those associations. The protein is produced in the liver, Liu said, and it may be that it is a bellwether of the body's metabolism.

Liu said the study supports the idea of adding SHBG, which is readily detectable in clinical blood work, to the standard of preventive care for patients at potential risk for type 2 diabetes.

"By the time you are checking blood glucose it's too late, [because] you use that as a diagnostic criterion to define diabetes," Liu said. "Our argument is that you can go to the doctor's office and check this protein that can predict your future risk six to 10 years down the line."


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Related biology news :

1. Gut microbes closely linked to proper immune function, other health issues
2. Early-onset Parkinsons disease linked to genetic deletion
3. Epilepsy drug dosage linked to specific birth defects
4. Vigorous physical activity linked to lower incidence of obesity in young African-American women
5. DHA-enriched formula in infancy linked to positive cognitive outcomes in childhood
6. Genetic mutations linked to Parkinsons disease
7. Neuroscientists identify protein linked to Alzheimers-like afflictions
8. Breast cancer surgery linked to swollen arm syndrome
9. Percentage of cancers linked to viruses potentially overestimated
10. Penn: New variants at gene linked to kidney disease, sleeping sickness resistance
11. Rapid upper ocean warming linked to declining aerosols
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... YORK , Feb. 2, 2016 /PRNewswire/ ... facilities are primarily focused on medical screening ... measure point-of-care parameters. Wearable devices that facilitate ... user,s freedom of movement are being bolstered ... for human biomedical signal acquisition coupled with ...
(Date:2/2/2016)... Va. , Feb. 2, 2016   ... award from the U.S. Army Research Office and ... the range and sensitivity of the company,s ... Past Accounting Mission and, more generally, defense-related DNA ... DNA phenotyping capabilities (predicting appearance and ancestry from ...
(Date:2/1/2016)... ( www.wocketwallet.com ) announces the launch of a new video featuring singer, ... Las Vegas , where Joey appeared at the Wocket booth to ... , where Joey appeared at the Wocket booth to meet and greet ... the Consumer Electronics Show (CES2016) in Las Vegas , ... --> --> The video is ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... --  BioInformant announces the February 2016 release of ... Tools, and Technologies – Market Size, Segments, Trends, and ... The first and only market research ... has more than a decade of historical information on ... cell type. This powerful 175 page global strategic report ...
(Date:2/10/2016)... -- Early-career researchers from Indonesia ... Uganda and Yemen ...   Indonesia , Nepal , ... Yemen are being honored for their accomplishments in nutrition, ... for mentoring young women scientists who are pursuing careers in agriculture, biology ...
(Date:2/10/2016)... Feb. 10, 2016  IsoRay, Inc. (NYSE MKT: ISR), ... and medical radioisotope applications for the treatment of prostate, ... announced its financial results for the second quarter and ... 2015. --> --> ... of fiscal 2016, which ended December 31, 2015, a ...
(Date:2/10/2016)... ... , ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their new ... San Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS Expo ... PIN diode standard packages feature a TO-46 metal can with active areas of 1.0mm ...
Breaking Biology Technology: