Navigation Links
Life's smallest motor, cargo carrier of the cells, moves like a seesaw
Date:2/18/2010

Life's smallest motor, a protein that shuttles cargo within cells and helps cells divide, does so by rocking up and down like a seesaw, according to research conducted by scientists at the U.S. Department of Energy's Lawrence Berkeley National Laboratory and Brandeis University.

The researchers created high-resolution snapshots of a protein motor, called kinesin, as it walked along a microtubule, which are tube-shaped structures that form a cell's "skeleton." The result is the closest look yet at the structural changes kinesin proteins undergo as they ferry molecules within cells.

"We see for the first time how kinesin's atomic-scale moving parts allow it to pull itself and its cargo along a microtubule," says Ken Downing, a biophysicist with Berkeley Lab's Life Sciences Division. He conducted the research with postdoctoral fellow Charles Sindelar, now at Brandeis University.

"We found that there is a pivot point, where the kinesin motor attaches to the microtubule, which acts like a fulcrum and causes kinesin to rock up and down like a seesaw as it moves along the microtubule," adds Downing.

Their research is reported this week in the online early edition of the Proceedings of the National Academy of Sciences.

The first-ever glimpse of kinesin's seesaw motion offers key insights into one of life's most fundamental processes. Fueled by an energy-giving compound called ATP, kinesin proteins motor along microtubules like trains on a railroad track, towing cargo to various locations within cells and assisting in cell division. Microtubules are a cylindrical weave of proteins found throughout cells that serve as cellular scaffolding.

Until now, scientists did not have a clear picture of what happens when ATP binds with kinesin, and especially how this process triggers structural changes in kinesin that propel the protein along microtubules.

Extremely high-resolution crystallography images of
'/>"/>

Contact: Dan Krotz
dakrotz@lbl.gov
510-486-4019
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Lifestyle changes for teens critical in light of research about teens heart disease risk
2. Lifestyle changes may stave off diabetes for a decade
3. Genomes reveal bacterial lifestyles: Research
4. American College of Preventive Medicine releases lifestyle medicine literature review
5. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
6. Late motherhood boosts family lifespan
7. Modern lifestyle prevents tooth decay
8. M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan
9. Sex and lifespan linked in worms
10. Scientists reveal the lifestyle evolution of wild marine bacteria
11. Eliminating germline lengthens fly lifespan, Brown study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Life's smallest motor, cargo carrier of the cells, moves like a seesaw
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/10/2015)... and TELTOW, Germany , August ... (SMI), a world leader in Eye Tracking Technology ... of its OEM Eye Tracking Platform for integration into ... Platform contains reference designs for seamless integration of eye ... virtual reality HMDs and augmented reality smart glasses. Omnivision,s ...
(Date:8/6/2015)... and TELTOW, Germany , August 6, ... Conference, SensoMotoric Instruments (SMI) shows the world,s ... , based on Epson,s Moverio BT-200 see-through head ... With this new solution, unprecedented quality and efficiency is ... with context-sensitive displays. For the first time, professionals and ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... Hippocampus adapts to environmental stresses, Stockpiles ... under favorable conditions, Knowledge of how neural stem cells ... diseases such as Alzheimer,s and Parkinson,s ... known for years that neurogenesis takes place throughout adulthood ...
... German . , The brains of all vertebrates ... the brain areas that control their singing behaviour could be ... songbird species, only the males sing and indeed, they do ... However, even species where both sexes sing identically, display the ...
... It sounds like something out of a comic book ... but that is exactly what two investigators at the Wellman ... In a report that will appear in the journal ... researchers Malte Gather, PhD, and Seok Hyun Yun, PhD, describe ...
Cached Biology News:Brain structure adapts to environmental change 2Birdsong independent of brain size 2Birdsong independent of brain size 3Single GFP-expressing cell is basis of living laser device 2Single GFP-expressing cell is basis of living laser device 3
(Date:9/3/2015)... ... September 03, 2015 , ... Michigan-based ... monitoring wearable early 2016. , The device, called the Halo H1, is ... and electrical sensing technology. These sensors track trending interstitial fluid levels in the ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... systems, analytical testing, education and consulting services for the medical device sector, ... products/processes development, design control, validation, quality assurance and regulatory compliance. Avarent will ...
(Date:9/2/2015)... , Sep. 02, 2015 ... announced the addition of Jain PharmaBiotech,s new report ... to their offering. This report follows ... characteristic that can be objectively measured and evaluated ... processes as well as pharmacological responses to a ...
(Date:9/2/2015)... ... September 02, 2015 , ... Drug companies increasingly ... BCC Research reveals in its new report that the U.S. will generate ... category and generates the most market demand. , BCC Research examines plant-derived ...
Breaking Biology Technology:Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3
... InterMune Phase 3 CAPACITY Program - ... retention rate in CAPACITY -, BRISBANE, Calif., Oct. 16 ... October 16, 2008, the Japanese,Ministry of Health, Labor and Welfare ... Co. Ltd. to market pirfenidone,for the treatment of patients with ...
... Analytical Technologies,Inc. (AATI), based in Ames, IA will expand ... of space to current operations. The expansion,adjoins the current ... the,ISU Research Park campus. Although the 35 person, 10 ... in 2 building on the,Research Park Campus, the expansion ...
... more than $80 million to create a leading center ... ... Oct. 16 Fueled by a grant from the John S.,and ... the creation of the BioInnovation Institute in,Akron -- a unique collaboration ...
Cached Biology Technology:InterMune Reports Japanese Regulatory Approval of Pirfenidone in IPF 2InterMune Reports Japanese Regulatory Approval of Pirfenidone in IPF 3InterMune Reports Japanese Regulatory Approval of Pirfenidone in IPF 4Advanced Analytical Technologies, Inc. Expands Into New Office and Production Space 2BioInnovation Institute in Akron Launched 2BioInnovation Institute in Akron Launched 3BioInnovation Institute in Akron Launched 4
... using PULSin may be superior to transfection ... traditional transfection, with PULSin you can study ... time course of proteins in cells. Likewise, ... information than traditional RNA interference experiments. ...
... innovative reagent for highly efficient transfer of ... cells. Unlike DNA transfection, with PULSin Protein ... timing of exogenous proteins in cells can ... be studied. Real time function blocking ...
Reacti-Bind DNA Coating Solution...
... Solutions has now entered the next frontier ... partnering up with Cellomics, Inc. The drug ... of Beckman Coulter‘s automated solutions systems and ... information at the sub-cellular level. The integration ...
Biology Products: