Navigation Links
Life under the laser
Date:8/28/2008

Researchers at The University of Nottingham have developed a unique technology that will allow scientists to look at microscopic activity within the body's chemical messenger system for the very first time, live as it happens.

The cutting edge laser technology has helped to attract 1.3 million from the MRC (Medical Research Council) for a five-year project that will offer a new insight into the tiny world of activity taking place within single cells and could contribute to the design of new drugs to treat human diseases such as asthma and arthritis with fewer side effects.

The team, involving scientists from the University's Schools of Biomedical Science (Professor Steve Hill and Dr Steve Briddon) and Pharmacy (Dr Barrie Kellam), is concentrating on a type of specialised docking site (receptor) on the surface of a cell that recognises and responds to a natural chemical within the body called adenosine.

These A3-adenosine receptors work within the body by binding with proteins to cause a response within cells and are found in very tiny and highly specialised area of a cell membrane called microdomains. Microdomains contain a collection of different molecules that are involved in telling the cell how to respond to drugs or hormones.

It is believed that these receptors play an important role in inflammation within the body and knowing more about how they operate could inform the future development of anti-inflammatory drugs that target just those receptors in the relevant microdomain of the cell, without influencing the same receptors in other areas of the cell. However, scientists have never before been able to look in detail at their activity within these tiny microscopic regions of a living cell.

The Nottingham researchers have solved this problem by creating novel drug molecules which have fluorescent labels attached. Using a cutting edge laser technology called fluorescence correlation spectroscopy, the fluoresce
'/>"/>

Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
01-159-515-793
University of Nottingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Yale undergrads Amazon trip yields a treasure trove of diversity
2. Genome of saltwater creature could aid understanding of gene grouping
3. New robot scouts best locations for components of undersea lab
4. Researchers find cancer-inhibiting compound under the sea
5. US EPA, UVMs Gund Institute team up to develop new ways to understand ecosystem services
6. Purple extremist thrives under inhospitable conditions
7. 8-day undersea mission begins experiment to improve coral reef restoration
8. Synthetic Biology: funders move to address social and ethical challenges
9. Ocean life under threat from climate change
10. School of Robofish provides basis for underwater robot teams
11. Holistic understanding: Ag chemicals in the environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... of people in the United States have a circulatory ... can be painful and may even require surgery in ... muscle wasting and, in turn, limb amputation. , At ... (UTHealth) Medical School, scientists tested a non-surgical preventative treatment ... was associated with increased blood circulation. Their proof-of-concept ...
(Date:7/28/2014)... at Yale School of Medicine have pinpointed a mechanism in ... levels in the blood, linking it to both type 1 ... July 28 issue of Proceedings of the National Academies ... endopeptidase enzyme located in a part of the hypothalamus ... steps in motion that control glucose levels in the blood," ...
(Date:7/28/2014)... Eight of the top 10 U.S. cities that have ... public inconveniences as frequent road closures, overwhelmed storm drains ... a new NOAA technical report. , This nuisance flooding, ... three U.S. coasts, between 300 and 925 percent since ... Nuisance Flood Frequency Changes around the United States, also ...
Breaking Biology News(10 mins):Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3
... be tough, but scientists have found a Yellowstone National ... simple one-celled algae called Cyanidioschyzon -- thrives ... occurs naturally around hot springs, said Tim McDermott, professor ... at Montana State University. Cyanidioschyzon could ...
... is a commonly used indicator organism for detecting the ... of E. coli as an indicator organism has ... this important microorganism in groundwater environments. Commonly only a single ... studies, yet research has shown that a significant amount of ...
... March 6, 2009 -- As the first plant life ... earth, bryophytes offer a unique opportunity for researchers to ... three varieties of bryophites (liverworts, hornworts, and mosses) have ... local environments, but with the recent effects of climate ...
Cached Biology News:Montana State team finds Yellowstone alga that detoxifies arsenic 2Montana State team finds Yellowstone alga that detoxifies arsenic 3Transport behavior of E. coli varies depending on manure source 2How increased UV exposure impacts plants 2
(Date:7/28/2014)... Boston, MA (PRWEB) July 28, 2014 ... with two researchers to further develop potential treatments for ... brain tumor, in combination with their patented vaccine platform, ... and Duke University, are based on the work of ... of Neurosurgery at The Preston Robert Tisch Brain Tumor ...
(Date:7/28/2014)... 28, 2014 It’s a hard truth: Nearly ... to further their post-secondary education are failing to obtain a ... this year. And according to an analysis by The ... veteran students’ uninformed choice of college majors, which leads to ... the study: Some 51.7 percent of post-9/11 veterans using ...
(Date:7/28/2014)... COLLEGE STATION, Texas , July 28, 2014 /PRNewswire/ ... will be a 177-key, 4-star boutique hotel in the heart ... , Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... the first hotel within ATLAS , The ... mixture of standard rooms and suites, a sleek restaurant and bar, ...
(Date:7/26/2014)... (PRWEB) July 26, 2014 Canada ... key market data on the Canada Endoscopy Visualization ... of US dollars, volume (in units) and average ... High-End Endoscopy Visualization Systems, Mid-Range Endoscopy Visualization Systems ... Report at http://www.marketresearchreports.biz/analysis/213254 . , The report ...
Breaking Biology Technology:String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5
... 1938 to the impact of the Krakatoa eruption of 1883, ... of extreme weather. Now an international team of climatologists have ... 1871 to the present day, and from the earth,s surface ... Reanalysis Project, outlined in the Quarterly Journal of the ...
... done and now they,ve done it. What,s more, they did ... U.S. Department of Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley ... the first experimental demonstration of GRIN for gradient index ... a wide range of exotic optics, including superfast computers based ...
... Amgen (Nasdaq: AMGN ) today announced that it ... results on Monday, Jan. 24, 2011 after the close of ... conference call with the investment community at 2:00 p.m. Pacific ... Sharer, chairman and chief executive officer, and other members of ...
Cached Biology Technology:The 20th Century Reanalysis Project: A time machine for climate scientists 2The 20th Century Reanalysis Project: A time machine for climate scientists 3GRIN plasmonics 2GRIN plasmonics 3GRIN plasmonics 4Amgen Announces Webcast of 2010 Fourth Quarter and Full Year Financial Results 2
... use spatulas have been designed to save ... for those interested in eliminating the recycling ... spatula is individually packaged, RNase/DNase free, non-pyrogenic ... a new product number, created to easily ...
... been designed to save time and provide ... in eliminating the recycling and resterilizing necessary ... packaged, RNase/DNase free, non-pyrogenic and antistatic. Linkage: ... number, created to easily match Cornings product ...
... spatulas have been designed to save time ... those interested in eliminating the recycling and ... is individually packaged, RNase/DNase free, non-pyrogenic and ... new product number, created to easily match ...
... a base medium for preparation of minimal and ... but does not contain amino acids. Both bulk ... pouch contains reagents to prepare 500 ml of ... of 10X YNB for S. cerevisiae media. Store ...
Biology Products: