Navigation Links
Life-threatening gene defect located by UT-Houston researchers
Date:11/11/2007

HOUSTON (Nov. 11, 2007)A research team led by scientists at The University of Texas Medical School at Houston has identified a defective gene that affects vascular smooth-muscle cells in people who suffer from hereditary thoracic aortic disease, which can kill victims with little warning in the prime of their lives.

Thoracic aortic disease, specifically thoracic aortic aneurysms leading to aortic dissections, is the 15th leading cause of death in the country, killing up to 20,000 people a year. Actor John Ritter (age 54 years) and Rent creator Jonathan Larson (age 35 years) both died from the disease. Cardiac surgeons in the Texas Medical Center including Michael DeBakey. M.D., and Denton Cooley, M.D. pioneered the surgical repair of thoracic aortic disease.

The study, Mutations in Smooth Muscle Alpha-Actin (ACTA2) Lead to Thoracic Aortic Aneurysms and Dissections, will be published in the Nov. 11 issue of Nature Genetics.

Research on 14 families with 93 members from across the United States, along with Europe and Australia, led the team to a mutation in the smooth muscle cell alpha-actin (ACTA2), which affects muscular contractions in other blood vessels and the aorta. The wall of the aorta, the main blood vessel leading out of the heart, weakens and then enlarges, forming an aneurysm and ultimately leading to an aortic dissection, which often causes sudden death.

Our results suggest that contraction of the smooth muscle cells in the aorta is important in keeping it healthy and preventing the disease, said the studys senior author, Dianna M. Milewicz, M.D., Ph.D., professor and director of the Division of Medical Genetics at the UT Medical School. This information provides insight into the cause of this condition and helps us understand, for the first time, the pathology of the aortic wall degeneration.

Milewicz said that mutations in ACTA2 account for 14 percent of the inherited form of thoracic aortic an
'/>"/>

Contact: Deborah Mann Lake
deborah.lake@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston  
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Life-threatening gene defect located by UT-Houston researchers
(Date:7/13/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... BEHAVIORAL-DIRECTED AUTHENTIATION METHOD AND SYSTEM. ... method to make payments.  With this patent, NXT-ID ... its groundbreaking voice-direct payment patent application, with behavior-directed ...
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... Cambridge and Boston, MA. Wed. July 4, 2012 One ... after treatment. In the case of many forms of cancer, ... eradicate cancer cells in the lab, but often produce only ... in the field of cancer research has been and remains: ...
... new type of scholarly articles, which are rapidly gaining ... publications that describe data sets and provide an opportunity ... citation and re-use of the published data. Data Papers ... among the international organization Global Biodiversity Information Facilities ...
... coast of North America is reaching the level of the ... by a researcher at the University of British Columbia. ... Bulletin , examined stomach contents of beached northern fulmars on ... Washington and Oregon, U.S.A. "Like the canary in the ...
Cached Biology News:Tumor microenvironment helps skin cancer cells resist drug treatment 2Tumor microenvironment helps skin cancer cells resist drug treatment 3Tumor microenvironment helps skin cancer cells resist drug treatment 4A new type of data papers designed to publish online interactive keys identifying biodiversity 2Seabirds study shows plastic pollution reaching surprising levels off coast of Pacific Northwest 2
(Date:7/27/2015)... ... , ... Production of high tenacity filament yarn of viscose rayon (excluding sewing ... instance, it surpassed the EUR 106 million mark (in value terms) in 2013, while ... major producer, while Italy is a key consumer. , The high tenacity filament ...
(Date:7/27/2015)... , July 27, 2015 According ... by Type (Home-brew Media, Pre-formulated Media), by Application (Biobanking, Regenerative ... , Europe , Asia-Pacific ... 2019", The global biopreservation media market was valued at $247.7 ... $571.5 million by 2019, at a CAGR of 18.2% between ...
(Date:7/26/2015)... (PRWEB) , ... July 26, 2015 , ... ... of its VALIDATE® ANEMIA calibration verification / linearity test kit. The VALIDATE® ANEMIA ... Each VALIDATE® ANEMIA kit is prepared using the CLSI recommended “equal delta” method ...
(Date:7/24/2015)... , July 24, 2015  Champions Oncology (OTC-BB: CSBR), ... solutions and services to personalize the development and use ... financial and operational results for the fourth quarter and ... July 28, 2015, before market open. The ... results that day at 9:00 a.m. EDT (6:00 a.m. ...
Breaking Biology Technology:High Tenacity Filament Yarn of Viscose Rayon Consumption to Grow Swiftly in the EU, Forecasts BAC Reports in New Study Available at MarketPublishers.com 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 3Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2Champions Oncology to Announce Fourth Quarter Financial Results on Tuesday, July 28 2
... April 25 Kosan Biosciences,Incorporated (Nasdaq: KOSN ) ... May 1, 2008, after market close., The announcement ... by a conference call and live webcast on May ... Interested parties may access the live,call by dialing 888.680.0878 ...
... and Collaborators Publish Study in Science, ... GmbH, the,leading developer of RAFT intervention therapeutics, ... Science demonstrating a potential novel strategy,for therapeutic ... targeting,discrete sub-compartments in the cell membrane (RAFTS). ...
... Gen-Probe Incorporated,(Nasdaq: GPRO ) announced today that the ... Conference on May 1, 2008 at,approximately 4:20 p.m. Eastern ... may be accessed through a link on the investors ... will be,available for 30 days following the event., ...
Cached Biology Technology:Kosan Announces May 1, 2008 Conference Call and Webcast of First Quarter 2008 Financial Results 2Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS 2Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS 3Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS 4Gen-Probe to Webcast Presentation at Morgan Stanley Global Healthcare Unplugged Conference 2
... Yeast Cells are designed for use with ... cerevisiae strain MaV203 contains deletions in the ... with GAL4-based two-hybrid systems. The strain also ... of ProQuest bait and prey vectors. MaV203 ...
... designed for use with the ProQuest Two-Hybrid ... contains deletions in the endogenous GAL4 and ... systems. The strain also has leu2 and ... and prey vectors. MaV203 contains three GAL4 ...
Request Info...
... protein in 200 l SDS-PAGE Western blotting buffer, ... transformed macrophage cells, whole cell ... should be stored at -20C and ... sample vial should be boiled once ...
Biology Products: