Navigation Links
Life-threatening gene defect located by UT-Houston researchers
Date:11/11/2007

HOUSTON (Nov. 11, 2007)A research team led by scientists at The University of Texas Medical School at Houston has identified a defective gene that affects vascular smooth-muscle cells in people who suffer from hereditary thoracic aortic disease, which can kill victims with little warning in the prime of their lives.

Thoracic aortic disease, specifically thoracic aortic aneurysms leading to aortic dissections, is the 15th leading cause of death in the country, killing up to 20,000 people a year. Actor John Ritter (age 54 years) and Rent creator Jonathan Larson (age 35 years) both died from the disease. Cardiac surgeons in the Texas Medical Center including Michael DeBakey. M.D., and Denton Cooley, M.D. pioneered the surgical repair of thoracic aortic disease.

The study, Mutations in Smooth Muscle Alpha-Actin (ACTA2) Lead to Thoracic Aortic Aneurysms and Dissections, will be published in the Nov. 11 issue of Nature Genetics.

Research on 14 families with 93 members from across the United States, along with Europe and Australia, led the team to a mutation in the smooth muscle cell alpha-actin (ACTA2), which affects muscular contractions in other blood vessels and the aorta. The wall of the aorta, the main blood vessel leading out of the heart, weakens and then enlarges, forming an aneurysm and ultimately leading to an aortic dissection, which often causes sudden death.

Our results suggest that contraction of the smooth muscle cells in the aorta is important in keeping it healthy and preventing the disease, said the studys senior author, Dianna M. Milewicz, M.D., Ph.D., professor and director of the Division of Medical Genetics at the UT Medical School. This information provides insight into the cause of this condition and helps us understand, for the first time, the pathology of the aortic wall degeneration.

Milewicz said that mutations in ACTA2 account for 14 percent of the inherited form of thoracic aortic an
'/>"/>

Contact: Deborah Mann Lake
deborah.lake@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston  
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Life-threatening gene defect located by UT-Houston researchers
(Date:2/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces ... CEO Conference on January 29 th at 10:30 ... CEO of NXT-ID will present and host a live ... wallet and its full suite of biometric technologies. Investors ...
(Date:1/22/2015)... , Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: ... market in general the State of Washington,s ... for a new enrollment and central issuance system for driver,s ... The project planning and development will start in ...
(Date:1/22/2015)...  A man-made form of insulin delivered by nasal spray ... adults with mild cognitive impairment and Alzheimer,s disease dementia, ... Wake Forest Baptist Medical Center. The study,s ... impairment (MCI) or mild to moderate Alzheimer,s dementia (AD). ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... a decade of satellite data, a team of scientists led ... by NASA has created a model that can successfully predict ... rain forest and the rest of South America months in ... settlement patterns are the primary factor that drives the distribution ...
... The Advanced Technology Microwave Sounder (ATMS) on board NASA,s newest ... 2011. The image shows the ATMS channel 18 data, which ... is visible in the data, as the patch of blue, ... States. The data were processed at the NOAA Satellite Operations ...
... the number of seeds they produce, or their relative fitness, ... pollen. The number of visits a plant may receive depends ... density. But what if a plant happens to grow in ... visiting its flowers? Will all the effort put into flowering ...
Cached Biology News:Ocean temperatures can predict Amazon fire season severity 2Ocean temperatures can predict Amazon fire season severity 3NASA'S NPP satellite acquires first ATMS measurements 2How does a plant survive with few mates or pollinators? A European herb has figured out its own way 2How does a plant survive with few mates or pollinators? A European herb has figured out its own way 3
(Date:3/5/2015)... , March 5, 2015  DuPont (NYSE: ... Transportation and Industrials Conference held today in ... Matthew L. Trerotola discussed strategy, progress and plans ... for DuPont.  Strengthening and growing the company,s leading position ... areas of strategic priority for DuPont. Discussing ...
(Date:3/5/2015)... 2015  Twelve patients today are preparing to participate ... at California Pacific Medical Center (CPMC), a Sutter Health ... will be the largest single-center kidney paired donation chain ... in the 44-year history of the CPMC Transplant Center. ... an altruistic donor who did not have a specific ...
(Date:3/5/2015)... 2015   HX360 today announced that sixteen ... HX360 Innovation Challenge competition. These companies, selected from ... chosen as one of four finalists to present their ... executives and venture capitalists during the Innovation Challenge event. ... at the 2015 HIMSS Annual Conference & Exhibition, McCormick ...
(Date:3/5/2015)... Buffalo, New York (PRWEB) March 05, 2015 ... want veterans to be able to get an Advanced ... Time, money, stress, blaming and guessing are all risk ... with assuming the woman is the source of the ... and female. LifeCell Dx has the simplest, least ...
Breaking Biology Technology:DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 3DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 4Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 2Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 3Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 4HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4LifeCell Dx Offers New Option to Veterans with Infertility 2LifeCell Dx Offers New Option to Veterans with Infertility 3
... NY, February 29, 2008 miRNA research is ... the life science world, reports Genetic Engineering and ... studying the effects of over- or underexpression of ... pathogenesis in a variety of diseases, according to ...
... Inc.,(Nasdaq: MITI ), a biopharmaceutical company developing ... and autoimmune,diseases, today announced that Dr. Christian Itin, ... at the Susquehanna Financial,Group,s SIGnificant Investment Options Conference ... at the W Hotel in New York., ...
... CINCINNATI, Feb. 29 Kendle (Nasdaq: ... organization, today,announced that Vice President and Chief ... 29th Annual Raymond James,Institutional Investors Conference. The ... Grand Cypress in Orlando, March 2-5, 2008. ...
Cached Biology Technology:Micromet to Present at the Susquehanna Financial Group's SIGnificant Investment Options Conference on March 4, 2008 2Kendle to Present at the 29th Annual Raymond James Institutional Investors Conference 2
... The StatMatic I provides a convenient and ... culture work. Used with an eight-port disposable ... not possible with multi-channel pipettes. The eight-port ... in volumes of 100, 200, 250, or ...
384 Well PCR Plate Carrier for Thermo-Sealer...
These 18x18 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick....
... are hydrophobic cover slips for in ... genomic arrays on glass slides., ... Hybri-slips do not adsorb probes. , ... to use. , Avoid RNA degradation-Hybri-slips ...
Biology Products: