Navigation Links
Life secret exposed: Scientists unlock mystery of molecular machine
Date:2/19/2009

This release is available in French.

Montreal, February 19, 2009 A major mystery about the origins of life has been resolved. According to a study published in the journal Nature, two Universit de Montral scientists have proposed a new theory for how a universal molecular machine, the ribosome, managed to self-assemble as a critical step in the genesis of all life on Earth.

"While the ribosome is a complex structure it features a clear hierarchy that emerged based on basic chemical principles," says Sergey Steinberg, a Universit de Montral biochemistry professor who made his discovery with student Konstantin Bokov. "In the absence of such explanations, some people could imagine unseen forces at work when such complex structures emerge in nature."

What is a ribosome?

The ribosome is an enormous molecule responsible for translating the messages carried in the genetic code of all organisms into the workhorse molecules of the cell proteins that carry out all functions, including replicating the genome itself. As the world celebrates the bicentennial anniversary of the Father of Evolution, Charles Darwin, Prof. Steinberg's theory brings the scientific community even deeper into the study of the origins of life.

By examining the molecular self-organizing processes that preceded the living cell, the point where time begins for biologists, Prof. Steinberg goes further than Darwin and the many evolutionary biologists who followed could have imagined

By the standards of biological molecules, ribosomes are immense. Though visible only through lenses of the most powerful microscopes, comparing most other biological molecules to this behemoth is like comparing a tricycle to a jumbo jet. Having spent years gazing at the detailed structure of the ribosome, Prof. Steinberg pondered how such an immense and complex structure could have assembled itself from smaller building blocks that existed on the early Earth.

From the simple to the complex

The key breakthrough came when he realized that the ribosome is organized by a set of simple structural rules and that it had to be assembled from basic building blocks in a very specific order; otherwise it would have fallen apart. He then showed with mathematical rigor that the construction of the ribosome likely followed an ordered series of steps to form the structure found in the first living cell. To this day, that structure exists almost unchanged in our own cells.

Chemists have been able to observe many examples of self-organizing behavior with simple molecules, yet explaining the complex self-assembly of biomolecules had not been so obvious.

"Thanks to the research of Sergey Steinberg and Konstantin Bokov, scientists now have a glimpse of one key event that emerged spontaneously out of the primordial chemical soup of the early Earth," explains Stephen Michnick, a Universit de Montral biochemistry professor and Canada Research Chair in Integrative Genomics. "Perhaps in the near future we may look forward to more discoveries that will take us beyond the world of Darwin into an understanding of the basic chemical principles that drove the emergence of life on our planet and perhaps beyond."


'/>"/>

Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology news :

1. Caltech researchers help unlock the secrets of gene regulatory networks
2. Scientists unlock possible aging secret in genetically altered fruit fly
3. DNA testing may unlock secrets of medieval manuscripts
4. Princeton-led team finds secret ingredient for the health of tropical rainforests
5. Expeditions reveal gulf of Californias deep sea secrets, as well as human imprints
6. Grays Paradox solved: Researchers discover secret of speedy dolphins
7. Uncovering secrets of life in the ocean
8. Caltech biologists spy on the secret inner life of a cell
9. Landmark study unlocks stem cell, DNA secrets to speed therapies
10. The making of Dig It! the Secrets of Soil exhibit
11. Human embryonic stem cell secretions minimized tissue injury after heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
(Date:10/5/2017)... YORBA LINDA, CA (PRWEB) , ... October 05, 2017 , ... ... tech innovators, engineers, and scientists from around the world, is giving back to cancer ... shirt sold in October. , Now through October 31, shoppers can use promo ...
Breaking Biology Technology: