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Life Technologies, TGen and US Oncology partner on groundbreaking breast cancer sequencing research
Date:3/5/2010

CARLSBAD, Calif., PHOENIX, Ariz. and THE WOODLANDS, Texas March 5, 2010 Life Technologies Corporation (NASDAQ: LIFE) today announced that it is collaborating with the Translational Genomics Research Institute (TGen) and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies. The goal of this first-of-its-kind research collaboration is to demonstrate whether genomic sequencing of cancer tissue can provide clues for treatment strategies for these individuals.

While genomic sequencing has made great strides in helping researchers understand human disease, its clinical utility is not fully known. This research study brings together the accuracy of the Applied Biosystems SOLiD System, with US Oncology's expertise in cancer trials and TGen's Cancer Genome and Oncology programs, to provide additional information for oncologists and their patients. Triple negative tumors, which make up nearly 20 percent of breast cancers, do not respond to treatment with common targeted breast cancer therapies such as Herceptin.

"This study could provide insight into how cancers can be potentially treated in the future," said Daniel D. Von Hoff, M.D., Physician-in-Chief, Senior Investigator for TGen and Chief Scientific Officer for US Oncology & Scottsdale Healthcare's Virginia G. Piper Cancer Center. "Current clinical trials are aimed at showing how one new drug can be safe and effective across hundreds of people. This study flips that concept by using sequencing data from one individual to evaluate which anti-cancer drugs could be most effective based on normal and tumor genetic makeup. This is truly the definition of genomic medicine."

Cancer is caused by mutations across the genome that affect genes coding for proteins involved in cellular processes. Understanding these mutations and their impact on biological pathways and processes becomes critical
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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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