LX4211 is an orally-delivered small molecule under development as a potential treatment for diabetes. LX4211 inhibits both sodium-glucose cotransporter type 2, or SGLT2, and sodium-glucose cotransporter type 1, or SGLT1. SGLT2 is a transporter responsible for most of the glucose reabsorption performed by the kidney. SGLT1 is a transporter responsible for glucose and galactose absorption in the gastrointestinal tract, and to a lesser extent than SGLT2, glucose reabsorption in the kidney. In a combined Phase 1 single ascending-dose and multiple ascending-dose study, LX4211 was well tolerated at all dose levels and produced a dose-dependent increase in urinary glucose excretion. In preclinical studies, animals treated with LX4211 demonstrated increased urinary glucose excretion and decreased blood HbA1c levels (a marker of long-term blood sugar levels). Importantly, urinary glucose excretion returned to baseline after treatment was discontinued.
For more information on LX4211, and to access the presentations (available after June 21 and 28, 2010, respectively), please visit www.lexpharma.com.
Lexicon is a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease. Lexicon currently has four drug candidates in mid-stage development for diabetes, i
|SOURCE Lexicon Pharmaceuticals, Inc.|
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