Navigation Links
Leukemia patients remain in remission more than 2 years after engineered T cell therapy
Date:12/9/2012

ization and carries at least a 20 percent mortality risk -- and even then offers only a limited chance of cure for patients whose disease has not responded to other treatments.

Three abstracts about the new research will be presented during the ASH meeting. David Porter, MD, director of Blood and Marrow Transplantation in the Abramson Cancer Center, will give an oral presentation of Abstract #717 on Monday, Dec. 10, at 5 PM in the Thomas Murphy Ballroom 4, Level 5, Building B of the Georgia World Congress Center. Michael Kalos, PhD, director of the Translational and Correlative Studies Laboratory at Penn, will give an oral presentation on Abstract #756 on Monday, Dec. 10, at 5:45 PM in C208-C210, Level 2, Building C. Stephan Grupp, MD, PhD, director of Translational Research in the Center for Childhood Cancer Research at the Children's Hospital of Philadelphia, will present a poster of Abstract #2604 on Sunday, Dec. 9, at 6 PM in Hall B1-B2, Level 1, Building B.

The protocol for the new treatment involves removing patients' cells through an apheresis process similar to blood donation, and modifying them in Penn's cell and vaccine production facility. Scientists there reprogram the patients' T cells to target tumor cells through a gene modification technique using a HIV-derived lentivirus vector. The vector encodes an antibody-like protein, called a chimeric antigen receptor (CAR), which is expressed on the surface of the T cells and designed to bind to a protein called CD19.

The modified cells are then infused back into the patient's body following lymphodepleting chemotherapy. Once the T cells start expressing the CAR, they focus all of their killing activity on cells that express CD19, which includes CLL and ALL tumor cells, and normal B cells. All of the other cells in the patient that do not express CD19 are ignored by the modified T cells, which limits systemic side effects typically experienced during traditional therapies.'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Gene sequencing project identifies abnormal gene that launches rare childhood leukemia
2. Chernobyl cleanup workers had significantly increased risk of leukemia
3. Gene discovery could improve treatment for acute myeloid leukemia
4. miR loss may power maligant transformation in chronic leukemia
5. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
6. Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia
7. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
8. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
9. Ray of hope for human Usher syndrome patients
10. Walking on marbles could be a thing of the past for arthritis patients
11. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... A new Dartmouth College study finds human-caused climate ... of tropical lizards, contradicting a host of recent ... rapidly warming planet. , The findings, which appear ... offer new hope for survival of a creature ... Most predictions that tropical cold-blooded animals, especially forest ...
(Date:5/16/2013)... MARC (Maximizing Access to Research Careers) Program has ... Society (ENDO) 95th Annual Meeting in San Francisco, ... meant to promote the entry of students, postdoctorates ... of the basic science community and to encourage ... 2013 Annual Meeting. , Awards are given to ...
(Date:5/16/2013)... University scientists have shown a gene involved in neurodegenerative ... function of the circadian clock. , In a ... the gene, called Ataxin-2, keeps the clock responsible for ... gene, the rhythm of the fruit fly,s sleep-wake cycle ... difficult for the fly. , The discovery is ...
Breaking Biology News(10 mins):Climate change may have little impact on tropical lizards 2Gene involved in neurodegeneration keeps clock running 2
... - the idea of using genetic instructions rather than drugs ... but is not yet a viable therapeutic method. One ... place at the right time. , Engineers at the University ... problem. David M. Lynn and his colleagues have created ...
... hit all his developmental landmarks but after his first birthday he ... infection. He stopped eating and was no longer happy and playful. ... at us anymore; he was in his own little world. At ... and was smearing (feces) on the walls. My baby had been ...
... the urgent need for alternative energy, Florida Tech ... a $430,000 contract from Aurora Biofuels for large-scale ... so far is in small-scale cultivation. , Lin ... Vero Beach Marine Laboratory. His work is to ...
Cached Biology News:Ultrathin films deliver DNA as possible gene therapy tool 2Ultrathin films deliver DNA as possible gene therapy tool 3Army research mission focused on autism 2Army research mission focused on autism 3Army research mission focused on autism 4
(Date:5/20/2013)... Interventional cardiologist Tony Farah, MD, and his ... Cardiovascular Institute have helped pioneer many breakthroughs in ... over the past three decades, from new disease-fighting medications ... artery stent implantation. , Today, AGH officials announced that ... in the study of a novel, first-of-its kind investigational ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 Recognizing ... young faculty members to its 2013 Class of ... the company will provide this outstanding international group ... in advancing basic science to meet global challenges.     ... to help promising young and untenured research faculty ...
(Date:5/20/2013)... Kitware, a leader in data visualization, ... the exploration of hospital costs across the United ... the recent release of “Medicare Provider Charge Data,” a ... procedures from the Centers for Medicare & Medicaid Services. ... at hospitals across the country has sparked considerable controversy; ...
(Date:5/20/2013)... City, CA (PRWEB) May 20, 2013 ... has announced the appointment of Lisa Baird as Executive ... on July 8, 2013. The WMIS vision ... imaging applications to understand and effectively treat diseases in ... Imaging Society (WMIS) was established in 2011 by integrating ...
Breaking Biology Technology:Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 2Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 3Allegheny General Hospital Cardiovascular Institute Becomes Exclusive Pittsburgh Site for Study of Novel Coronary Artery Disease Device 4DuPont Celebrates Scientific Innovation by Recognizing Young Professors 2DuPont Celebrates Scientific Innovation by Recognizing Young Professors 3Kitware Enables Interactive Exploration of CMS Medicare Data 2WMIS Appoints Lisa Baird as Next Executive Director 2
... the Wisconsin Alumni Research Foundation's European stem ... , ,The foundation's stem cell patent is controversial enough ... overly broad and is suppressing scientific research. While that ... than 300 academic licenses it has issued for stem ...
... is entering a new phase. Both are headed to a jumpsuit ... years but the ex-heads of Enron - Ken Lay and Jeff ... thoroughly non-gullible jury of their fellow Houstonians. The duo will soon ... their crimes. , , When Creative Becomes Criminal ...
... always taken for granted was the quality of sound on ... emphasized that "you can hear a pin drop" as they ... ,The old Bell system also had very stringent requirements for ... digital lines with digital repeaters (amplifiers) that actually regenerated the ...
Cached Biology Technology:WARF stem cell patent faces long and winding road 2WARF stem cell patent faces long and winding road 3WARF stem cell patent faces long and winding road 4WARF stem cell patent faces long and winding road 5Are there more Enrons out there? 2Are there more Enrons out there? 3Are there more Enrons out there? 4Is traditional voice quality an oxymoron with today's cellular, VoIP? 2Is traditional voice quality an oxymoron with today's cellular, VoIP? 3
Human SOST Affinity Purified Polyclonal Ab...
(3-[125I]iodotyrosyl26)Galanin, porcine, 370 kBq, 10 uCi. Category: IODINE LIGANDS....
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
Human Legumain Affinity Purified Polyclonal Ab...
Biology Products: