Navigation Links
Let's get moving: Unraveling how locomotion starts
Date:5/16/2012

While experiments in the 1970s using electrical brain stimulation identified areas of the brain responsible for starting locomotion, the precise neuron-by-neuron pathway has not been described in any vertebrate until now.

To find this pathway, Dr Edgar Buhl and colleagues in Bristol's School of Biological Sciences studied a small, simple vertebrate: the Xenopus frog tadpole.

They found that the pathway to initiate swimming consists of just four types of neurons. By touching skin on the head of the tadpole and applying cellular neurophysiology and anatomy techniques, the scientists identified nerve cells that detect the touch on the skin, two types of brain nerve cells which pass on the signal, and the motor nerve cells that control the swimming muscles.

Dr Buhl said: "These findings address the longstanding question of how locomotion is initiated following sensory stimulation and, for the first time in any vertebrate, define in detail a direct pathway responsible. They could thus be of great evolutionary interest and could also open the path to understanding initiation of locomotion in other vertebrates."

When mechanisms in the brain that initiate locomotion break down for example, in people with Parkinson's disease starting to walk becomes a real problem. Therefore, understanding the initiation of swimming in tadpoles could be a first step towards understanding the initiation of locomotion in more complex vertebrates, including people, and may eventually have implications for treating movement disorders such as Parkinson's.

The research is published today in the Journal of Physiology.


'/>"/>

Contact: Hannah Johnson
hannah.johnson@bristol.ac.uk
44-117-928-8896
University of Bristol
Source:Eurekalert

Page: 1

Related biology news :

1. Providing toilets, safe water is top route to reducing world poverty: UN University
2. Just a little squeeze lets proteins assess DNA
3. Single gene lets bacteria jump from host to host
4. New reference material can improve testing of multivitamin tablets
5. Researchers explore new driver of transplant rejection: Platelets
6. Childrens National research links platelets to sepsis-related organ failure
7. Lipid droplets lead a Spartin existence
8. BIO-key(R) Enters Strategic Partnership With Nlets
9. BIO-key(R) Enters Strategic Partnership With Nlets
10. Green tea component may help preserve stored platelets, tissues
11. New nanochemistry technique encases single molecules in microdroplets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 9, 2014  Wake Forest Baptist Medical Center today announced ... School of Medicine. Funding for this $50 million capital ... will be publicly launched next summer. ... former 60 series R.J. Reynolds Tobacco Company complex, adjacent ... begin immediately with plans to be ready to welcome ...
(Date:12/10/2014)... December 9, 2014   ... Platform   Jifflenow, ... scheduling solutions for business-to-business (B2B) events, today announced ... in mobile near-field communication (NFC), Bluetooth low energy ... (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate ...
(Date:12/4/2014)... BEACH GARDENS, Fla. , Dec. 3, 2014 ... management solutions, today announced that its DigitalPersona ® ... 4500 fingerprint readers have been deployed throughout First ... , South Carolina ... headquartered in Southern Pines, North Carolina ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... Cold-weather garden enthusiasts have a new reason to celebrate. ... of Ohio have introduced an innovative, all-natural foliar spray ... their natural "anti-freeze" properties. According to the scientists, using ... 200 miles souththe equivalent of about one-half of a ...
... plants can actually "sense" day length, and "schedule" ... These natural events are based on the circadian ... and physiological processes. Plants grow better in circadian ... now researchers have not understood how plants, internal ...
... . With 100 billion nerve cells, the brain ... to understand the development program behind," says Dr. Steffen Scholpp from ... the brain develop, this means, what makes precursor cells build a ... the development of the thalamus. "It is the central interface between ...
Cached Biology News:New eco-friendly foliar spray provides natural anti-freeze 2How exposure to irregular light affects plant circadian rhythms 2Toward a therapy to healing stroke 2
(Date:12/19/2014)... iLab Solutions, the global leader in ... Bryant as the new Director of Institutional Implementations and ... These two new leadership positions were created to support ... that iLab continues to meet the needs of its ... iLab has been deployed at over 450 core facilities ...
(Date:12/19/2014)... 18, 2014 Egenix, Inc. is pleased to announce ... of the Board, to succeed Donald Fresne ; Mr. ... continue as a member of the Board.  In recognition of ... the company over almost twenty years, the Board designated Mr. ... Directors has established a Search Committee to find a suitable ...
(Date:12/17/2014)... USA (PRWEB) December 16, 2014 ... manager at Philipps- Universität Marburg’s Department of Physics, ... photonics, in the newly released SPIE Women ... never be too shy to ask questions.” , ... technology, engineering, and mathematics) occupations ranging from university ...
(Date:12/17/2014)... IN (PRWEB) December 17, 2014 ... Laboratory Excellence following its most recent COLA inspection. ... by COLA, a national healthcare accreditation organization. Accreditation ... standards of quality in day-to-day operations, demonstrate continued ... pass a rigorous on-site laboratory survey. ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... Candidate Enters Clinical Trials, REDWOOD CITY, Calif., ... novel antibody therapeutics that target,cancer stem cells, today ... its Series B financing round, raising $93 million. ... $154 million. New investor Nomura,Phase4 Ventures participated in ...
... study success at Berlin conference, RALEIGH, N.C., ... Organization announces it will present during the,Partnerships in ... in Berlin,Germany. PRA,s Christian Tucat, Senior Vice President ... in the evolution of CRO,partnerships?" at 4PM on ...
... (NTI(R)) (Nasdaq: NTII ), today announced it will ... ended September,30, 2008, and host a conference call on ... Paul E. Freiman, President and Chief Executive,Officer, and Matthew ... for the call are as follows:, Live ...
Cached Biology Technology:OncoMed Pharmaceuticals Completes Series B Financing 2OncoMed Pharmaceuticals Completes Series B Financing 3PRA International Addresses Sponsor-CRO Partnering Strategies at European Partnerships in Clinical Trials Congress 2Neurobiological Technologies Sets Date for First Quarter Financial Results 2
... Customer Peptide Synthesis , Containing one Phospho-Amino Acid ... be returned to customer conjugation of peptide to KLH protein ... 102 days/each , Pre-immune bleed x1 /each ... , Test bleed (app. 5 ml) x1 /each ...
Donor Goat Serum...
Human ICAT Affinity Purified Polyclonal Ab...
One-step, microplate or cuvet, colorimetric, detection range 0.04% to 4%. Procedure: 30 min....
Biology Products: