Navigation Links
Leptin's long-distance call to the pancreas
Date:12/22/2008

Rube Goldbergthe cartoonist who devised complex machines for simple taskswould have smiled at one of leptin's mechanisms for curbing insulin release. As Hinoi et al. show, the fat-derived hormone enlists the sympathetic nervous system to prevent bone-making cells from releasing a molecule that prods the pancreas to discharge insulin.

The study will appear online December 22, 2008 (www.jcb.org) and in the December 29, 2008 print issue of The Journal of Cell Biology (JCB).

In the fight against obesity and diabetes, leptin is one of the good guys. Mice lacking the hormone become corpulent, and their sky-high insulin levels eventually lead to diabetes. Leptin can curtail insulin release directly. But there's also a back-door route that researchers are still trying to piece together. Scientists knew that leptin nudges osteoblasts, cells known for building bone but that also manufacture osteocalcin, a protein that stimulates insulin release. Hinoi et al. tested whether leptin acts on the pancreas through osteocalcin.

Leptin channels many of its effects through the nervous system. The team thus tested whether the hormone relied on the sympathetic nervous system, the branch that pumps out adrenaline during emergencies but at other times emits a hormonal trickle to maintain a low level of stimulation. This baseline activity was lower in mice lacking the leptin receptor, indicating a connection between leptin and the sympathetic nervous system. When that connection was broken by deleting the adrenaline receptor from mice osteoblasts, insulin levels shot up.

The researchers then dosed mice with a sympathetic stimulator. Rodents lacking leptin or the adrenaline receptor on their osteoblasts turned out normal amounts of osteocalcin, but much of it was in an inert form. That result suggests leptin affects insulin release by indirectly inactivating osteocalcin. The work boosts researchers' hopes of using osteocalcin to treat diabetesa possibility some drug companies have already started to investigate.


'/>"/>

Contact: Rita Sullivan
rsullivan@rockefeller.edu
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Related biology news :

1. Jefferson Department of Surgery announces new pancreas tumor registry
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Leptin's long-distance call to the pancreas
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: