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Leptin action in the brain linked to sepsis survival
Date:4/30/2010

response to sepsis, and damage to this circuitry, or even leptin deficiency, may lead to higher risk of death from sepsis.

"Human congenital leptin deficiency is rare," the authors say, "with less than a few dozen patients reported worldwide to date. But there is a stunning number of recorded cases of death due to sepsis in this patient population."

In addition, Tschp says, this new finding gives researchers clues that could help in developing therapeutic targets for treating infection in people with damaged leptin-dependent neurocircuitry.


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Contact: Dama Kimmon
dama.kimmon@uc.edu
513-558-4519
University of Cincinnati Academic Health Center
Source:Eurekalert

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