Navigation Links
Lengthening time a drug remains bound to a target may lead to improving diagnostics, therapy
Date:4/25/2010

ANAHEIM, CA Studies led by Stony Brook University professor of chemistry Peter J. Tonge indicate that modifications that enhance the time a drug remains bound to its target, or residence time, may lead to better diagnostic and therapeutic agents.

Tonge will present these results at the American Society for Biochemistry and Molecular Biology's annual meeting in a talk titled "Slow Onset Inhibitors of Bacterial Fatty Acid Biosynthesis: Residence Time, In Vivo Activity and In Vivo Imaging." The talk will be held in Anaheim Convention Center Room 304C, on Sunday April 25 at 9:55 am PST.

"Our research team believes that many drugs are effective because they have long residence times on their target," says Tonge, Director of Infectious Disease Research at the Institute for Chemical Biology & Drug Discovery. "This concept has largely been ignored by investigators, and residence time is not usually incorporated into the drug discovery process."

Tonge explains that most drug discovery efforts obtain only data on the thermodynamic affinity of the drug for its target, measurements that are made at constant drug concentration. However, the Stony Brook University-led research factors in residence time, which he emphasizes is critical for activity in vivo where drug concentrations fluctuate with time.

"The central component of our work is that the length of time a drug remains bound to a target is very important for the activity of the compound in vivo," he adds.

Tonge, together with collaborators at Colorado State University and the University of Wrzburg in Germany, have developed a series of compounds that inhibit an enzyme target from Francisella tularensis, where the in vivo antibacterial activity of the compounds correlates with their residence time on the target and not with their thermodynamic affinity for the target. This resulted in a direct correlation between residence time and in vivo activity against an infectious a
'/>"/>

Contact: Nicole Kresge
nkresge@asbmb.org
202-316-5447
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Northern forests do not benefit from lengthening growing season
2. Ancient remains put teeth into Barker hypothesis
3. A year after discovery, Congos mother lode of gorillas remains vulnerable
4. Lead-based consumer paint remains a global public health threat
5. Analysis of Copernicus putative remains support identity
6. Laughter remains good medicine
7. Laughter remains good medicine
8. Accelerated bone turnover remains after weight loss
9. New technique determines the number of fat cells remains constant in all body types
10. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
11. Fear of being laughed at crosses cultural boundaries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, ... publication of a study that pinpoints fine-scale differences in ... United States . Since immigrants first ... the United States has served as a ... illuminates how American history and the ongoing mixing of ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/17/2014)... 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend ... for medical sensors in biomedical applications. Chemical sensors ... and correct diagnosis during surgical procedures. The Global ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... But in a new disease-fighting role. Viruses that infect and ... era a century ago and in the former Soviet Union ... of the sticky "biofilms" of bacteria responsible for infections on ... the ACS journal Biomacromolecules . Marek Urban and ...
... FRANCISCO , May 8, 2013 Many people are ... treating eye conditions, but few may be aware of the ... the spotlight this month when Leonard Flom ... , M.D. (1926-2007), were inducted into the United States Patent ...
... On May 8 th JoVE will publish ... in bacteria. This new technology is a preliminary step in ... has led to more deaths than AIDS in the United ... of collaboration between Dr. Vitaly Vodyanoy at Auburn University and ...
Cached Biology News:Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame 2Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame 3Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs 2
(Date:12/19/2014)... 2014   ISN has released its third ... publication series. With data aggregated from over ... 2013 within its online contractor management platform, ISNetworld, this ... indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... Achim Noack has been named global ... In this position, Noack will assist Jerry Stoller, CEO ... marketing strategy and supervise global marketing management and implementation ... tremendous knowledge and experience in the crop protection industry,” ... and innovative thinking will be a great asset for ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat ... Phase 2 study evaluating the investigational oral NK-1 ... patients with severe, chronic itch who are unresponsive ... care, including topical steroids and antihistamines. ... in Visual Analog Scale (VAS) itch score from ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4
... TSX: SHQ),the global specialty biopharmaceutical company, announces the release on,March 25, 2008, of ordinary shares ... Term Incentive Plan ("LTIP")., In accordance with the rules of the LTIP, the ... ... ...
... March 25 deCODE genetics,(Nasdaq: DCGN ) today ... deCODE,CEO Kari Stefansson,s presentation at BioCentury 2008 Future Leaders ... delivered at 1:30 PM ET / 5:30 GMT on,Thursday, ... Center,New York City. The webcast can be accessed through ...
... long is the menopausal,transition? New data suggest that it,s ... -- think. Clinicians often face challenges,determining if women will ... will last., To meet the needs of health ... have published two supplements dealing with,both the menopausal transition ...
Cached Biology Technology:Shire plc: Long Term Incentive Plan 2deCODE genetics to Webcast Presentation at 15th Annual Future Leaders in the Biotech Industry Conference 2Hot Information for Physicians Treating Vasomotor Symptoms During the Menopausal Transition 2
... This BioSafe room is configured ... testing and chemical analysis. Panels are ... are easy to wipe down and ... Unique double-wall panel design creates strong, ...
... chemical fumes, allowing safe indoor ... filters remove most organic contaminants. ... flow speed = 100 fpm ... air speed monitor, quick-release filter/blower ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... The Staccato Series of systems provide ... drug discovery , genomics, proteomics and drug ... three base configurations; Mini Workstation Series, Application ... Sciclone ELISA Station is a remarkably compact ...
Biology Products: