Navigation Links
Legionnaire's bacterial proteins work together to survive
Date:10/23/2007

New Haven, Conn.Proteins within the bacteria that cause Legionnaires disease can kidnap their own molecular coffin and carry it to a safe place within the cell, ensuring their survival, Yale School of Medicine researchers report in Nature Wednesday.

This supposedly simple organism continues to fascinate us with new tricks that enable it to manipulate cells in our body that normally protect us against bacterial infections, said the lead author, Craig Roy, associate professor of microbial pathogenesis at Yale.

Legionnaires disease acquired its name in 1976 when an outbreak of pneumonia occurred among people attending a convention of the American Legion in Philadelphia. The bacteria that causes itLegionella pneumophilareplicates inside macrophage, which are cells that are part of the immune system and eat cellular debris and toxins. Macrophages kill bacteria by transporting them in storage bubbles known as vacuoles to organelles that have enzymes to then break down the intruders.

What makes this pathogen special is that it can control transport of the vacuole formed after macrophages ingest the bacterium, Roy said. It hijacks the vacuole and directs it to be transported to a nutrient-rich organelle called the endoplasmic reticulum, where the bacteria replicate in high numbers.

Roy and his colleagues identified the Legionella proteins that are involved in the hijacking. They found that one protein, DrrA, that turns on a molecular switch, Rab1, and subverts its function. This allows the Legionella to fuse the endoplasmic reticulum and the vacuole, creating a compartment that ensures bacterial survival. They also found a second bacterial protein, LepB, that turns off the Rab1 switch once the bacteria have successfully entered the endoplasmic reticulum.

In other words, Roy said, you can think of Legionella as being a crafty burglar that enters a cell and uses the protein DrrA to turn on a light, Rab1, that will illumin
'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. A bacterial genome reveals new targets to combat infectious disease
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists discover that host cell lipids facilitate bacterial movement
5. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
6. Protein prevents detrimental immune effects of bacterial sepsis
7. Bacterial genome sheds light on synthesizing cancer-fighting compounds
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Researchers develop new method for facile identification of proteins in bacterial cells
10. A virus-like hitchhiker may trigger bacterial meningitis
11. Say what? Bacterial conversation stoppers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... BLUE BELL, Pa. , July 2, 2014  Unisys ... The Netherlands , Unisys Nederland N.V., today announced that ... (DJI) to deliver, implement and manage a new Basic Provision ... . Unisys won the contract with a ... for identity management software. The term of the contract is ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
(Date:7/10/2014)... 2014 According to a new ... Control Systems Market Global Forecast, Market Share, Size, Growth ... Access Control systems market was valued at USD 15,406.1 ... a CAGR of 12.6% from 2014 to 2019, to ... 2019. Browse the full Electronic Access Control ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... , BETHESDA, Md., June 24, 2010 The National ... five-year grant to the American Society for Biochemistry and ... for educators across the nation. The initiative aims ... by establishing foundational concepts and skills for the discipline ...
... grow with less fertilizer, herbicide, fuel, and erosion than ... according to researchers writing in the current issue of ... be one of the largest innovations in the 10,000 ... with the right breeding programs, said John Reganold, Washington ...
... University biomedical engineers and researchers from the University of ... device that is powerful enough to let doctors easily ... the LCD monitor on the back of the camera. ... camera were published online this week in the open-access ...
Cached Biology News:NSF grant will develop new online hub for biochemistry, molecular biology educators 2Agriculture's next revolution -- perennial grain -- within sight 2Off-the-shelf cancer detection 2
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
(Date:7/10/2014)... QC (PRWEB) July 10, 2014 EvoDerma ... and convenience. This rejuvenating device now comes with a second ... develops over time. , The new cup is thinner on ... design works to target rough, thin and uneven surfaces on ... firm cup for a stimulating treatment on areas such as ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... July 10, 2014  Kainos Capital, a firm specializing ... announced that it has acquired the Slim-Fast brand from ... business. Terms of the transaction were not disclosed. ... replacement business that markets ready-to-drink shakes, powders, bars and ... and in the United Kingdom ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Kainos Capital Acquires Slim-Fast From Unilever 2
... Oct. 3 Thermo Fisher,Scientific Inc. (NYSE: ... has acquired Priority,Solutions International, a leading third-party ... following anti-trust clearance.,Priority Solutions was previously majority-owned ... $95 million in 2006, Priority,Solutions offers a ...
... equity stake in Zenotech Laboratories to 45%, GURGAON, ... Laboratories Limited (Zenotech) today announced the,signing of Definitive Agreements, ... its current 7% to 45% at a price of ... involves: (a) Purchase of shares from the existing ...
... With a special eye for the,details hidden from ... Mara G. Aspinall. Photographs of architectural details from beaches,to ... the fore. The,collection includes images from seven different countries., ... Aspinall, the,president of Genzyme Genetics, is also a talented ...
Cached Biology Technology:Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 3Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 4Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3An Uncommon Eye: Photography Exhibit by Biotechnology Executive at BHCC Gallery 2
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Tumor Suppressor Sampler Kit 10 mu g each...
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Slide Chambers are convenient for performing pre-hybridization incubations and post-hybridization washes with tissue sections mounted on standard glass microscope slides. Each chamber holds up to 5 s...
Biology Products: