Navigation Links
Legionnaire's bacterial proteins work together to survive
Date:10/23/2007

New Haven, Conn.Proteins within the bacteria that cause Legionnaires disease can kidnap their own molecular coffin and carry it to a safe place within the cell, ensuring their survival, Yale School of Medicine researchers report in Nature Wednesday.

This supposedly simple organism continues to fascinate us with new tricks that enable it to manipulate cells in our body that normally protect us against bacterial infections, said the lead author, Craig Roy, associate professor of microbial pathogenesis at Yale.

Legionnaires disease acquired its name in 1976 when an outbreak of pneumonia occurred among people attending a convention of the American Legion in Philadelphia. The bacteria that causes itLegionella pneumophilareplicates inside macrophage, which are cells that are part of the immune system and eat cellular debris and toxins. Macrophages kill bacteria by transporting them in storage bubbles known as vacuoles to organelles that have enzymes to then break down the intruders.

What makes this pathogen special is that it can control transport of the vacuole formed after macrophages ingest the bacterium, Roy said. It hijacks the vacuole and directs it to be transported to a nutrient-rich organelle called the endoplasmic reticulum, where the bacteria replicate in high numbers.

Roy and his colleagues identified the Legionella proteins that are involved in the hijacking. They found that one protein, DrrA, that turns on a molecular switch, Rab1, and subverts its function. This allows the Legionella to fuse the endoplasmic reticulum and the vacuole, creating a compartment that ensures bacterial survival. They also found a second bacterial protein, LepB, that turns off the Rab1 switch once the bacteria have successfully entered the endoplasmic reticulum.

In other words, Roy said, you can think of Legionella as being a crafty burglar that enters a cell and uses the protein DrrA to turn on a light, Rab1, that will illuminate the location of the safe, the endoplasmic reticulum. Once Legionella has cracked the safe, LepB, turns off the light to avoid detection.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. A bacterial genome reveals new targets to combat infectious disease
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists discover that host cell lipids facilitate bacterial movement
5. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
6. Protein prevents detrimental immune effects of bacterial sepsis
7. Bacterial genome sheds light on synthesizing cancer-fighting compounds
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Researchers develop new method for facile identification of proteins in bacterial cells
10. A virus-like hitchhiker may trigger bacterial meningitis
11. Say what? Bacterial conversation stoppers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... Germany , March 20, 2017 At this ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG ... is this year,s CeBIT partner country. At the largest German ... biometrics in use: fingerprint, face and iris recognition as well as DERMALOGĀ“s ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , March ... Made Simple," and 23andMe , the leading personal ... food choices.  Zipongo can now provide customers with personalized ... health goals and biometrics, but also genetic markers impacting ... Zipongo,s personalized food decision support platform uses ...
(Date:3/2/2017)... Summary This report provides all ... and its partnering interests and activities since 2010. ... The Partnering Deals and Alliance since 2010 report provides ... of the world,s leading life sciences companies. ... ensure inclusion of the most up to date deal ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading ... data solutions, today announced that it is now offering ... U.S. consumers who want to have their DarioHealth products ... strategic alliance agreements with partners across the U.S. who ... if approved, will supply and bill the customer,s insurance ...
(Date:3/24/2017)... Md. , March 24, 2017  Infectex Ltd., ... (MBVF), today announced positive results of a Phase 2b-3 ... therapy regimen in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). ... scientists at Sequella, Inc. ( USA ) ... A total of 140 patients were enrolled in ...
(Date:3/24/2017)... YORK , March 24, 2017 ... ended the trading session at 5,817.69, down 0.07%; the ... at 20,656.58; and the S&P 500 closed at 2,345.96, ... as 4 sectors closed in green, 4 sectors finished ... day. This Friday, Stock-Callers.com has initiated reports coverage on ...
(Date:3/23/2017)... ... 23, 2017 , ... AxioMed president, Jake Lubinski, describes the ... when deformed, which is identical to how the human discs work to distribute ... return to its natural state along a hysteresis curve, exactly like a healthy ...
Breaking Biology Technology: