Navigation Links
Leemor Joshua-Tor, PhD, CSHL biologist and WSBS dean, is named an HHMI Investigator
Date:5/26/2008

Leemor Joshua-Tor, Ph.D., a CSHL professor and Dean of the Watson School of Biological Sciences, has been named a Howard Hughes Medical Institute (HHMI) Investigator.

Dr. Joshua-Tor, a structural biologist whose work is known and respected worldwide, is one of 56 new HHMI Investigators selected from among 1,070 applicants. They join approximately 300 Investigators in the Institutes flagship program, who lead Hughes laboratories at 64 institutions. At CSHL, HHMI Investigators include Gregory J. Hannon, Ph.D., and Scott Lowe, Ph.D.

Dr. Joshua-Tor is an outstanding researcher who, along with our other new Investigators, is poised to advance scientific knowledge dramatically in the coming years, said HHMI president and Nobel laureate Thomas R. Cech, Ph.D.

I speak for the entire faculty of CSHL in congratulating Leemor on this honor, which is richly deserved, said Bruce Stillman, Ph.D., CSHLs president. She has made significant discoveries in a number of areas and we have good reason to believe there are many more successes to come.

The Discovery of Slicer

Dr. Joshua-Tor has repeatedly demonstrated her productivity as a researcher. She is perhaps best known for her work in revealing structures involved in the gene-silencing mechanisms of RNA interference (RNAi). In 2004, she and a graduate student, Ji-Soon Song, used x-ray crystallography to identify an enigmatic protein called Slicer at the heart of the RNAi machinery. The appropriately named enzyme, a member of a family of proteins called Argonaute, acts to cleave messenger-RNAs that have paired with small interfering RNAs, effectively preventing a genes message from being expressed.

After solving for the structure of Argonaute, Dr. Joshua-Tor performed critical experiments with CSHL Professor Gregory Hannon, proving beyond a doubt that Argonaute was the only protein required for Slicer activity, and shedding light on a structural feature of the protein -- a groove in its topography -- into which a short RNA and messenger-RNA can nestle when the two are paired, prior to cleaving.

Making those discoveries are landmark moments in my career in science, but so is the honor that has now been bestowed upon me by HHMI, Dr. Joshua- Tor commented. I am grateful. Being named an HHMI Investigator bespeaks a trust that the institution has placed in our lab and in our ability to make valuable contributions to science. This is precisely what I intend to do.

Inner Workings of a Molecular Machine

Since her discovery of Slicer, Dr. Joshua-Tor has used structural biology and molecular biology tools to determine the structure of a protein called E1 that is found in papillomavirus, a DNA tumor virus that causes cervical cancer. Scientists knew that E1 was a member of a protein family called helicases that unwind the DNA double-helix during chromosome replication. They did not know, however, how helicases accomplished the task

Dr. Joshua-Tor and Eric Enemark revealed how six E1 proteins form a molecular machine that pulls a single strand of DNA through its channel and how it utilizes ATP to do this. Additional work is under way in the lab to determine more comprehensively how this helicase complex works.

Leemor Joshua-Tor was born in Israel and trained at Tel-Aviv University, where she earned a B.Sc. in chemistry, and at the Weizmann Institute of Science in Rehovot, where she earned a Ph.D. in chemistry. Dr. Joshua-Tor was a postdoctoral fellow at the California Institute of Technology prior to joining the CSHL faculty as an assistant investigator. She was named associate professor at CSHL in 1999 and professor in 2005. She is the recipient of the Dorothy Crowfoot Hodgkin Award from the Protein Society and a Beckman Young Investigator Award.

A gifted mentor, Dr. Joshua-Tor was named co-director of the undergraduate research program at the Watson School of Biological Sciences in 2001, and in 2007 was named the schools dean, succeeding Lilian Clark, Ph.D., M.B.A.


'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Plant biologists discover unexpected proteins affecting small RNAs
2. Biologists are from Mars, chemists are from Venus?
3. The story of Max Perutz, a pioneering biologist with a remarkable passion for life
4. Biologists at UC San Diego identify key protein in cells self-eating function
5. Biologists surprised to find parochial bacterial viruses
6. Cell biologists announce child-care grants for scientist-parents at annual meeting
7. Systems biologist finds novel solutions to fundamental biological problems
8. Ant parasite turns host into ripe red berry, biologists discover
9. UAB microbiologist wins top Czech science honor
10. Biologists find unusual plant gene: abstinence by mutual consent
11. Evolution is deterministic, not random, biologists conclude from multi-species study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
(Date:12/12/2016)... -- Researchers at Trinity College, Dublin, are opening up ... material with Silly Putty. The mixture (known as "G-putty") ... sense pulse, blood pressure, respiration, and even the ... The research team,s findings were published Thursday in ... Due ...
(Date:12/7/2016)... According to a new market research report "Emotion Detection ... Voice Recognition), Service, Application Area, End User, And Region - Global Forecast to ... 6.72 Billion in 2016 to USD 36.07 Billion by 2021, at a Compound ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:1/17/2017)...   Pulmatrix, Inc . (NASDAQ: PULM ... therapies to address serious pulmonary diseases, today announced that ... lungs of CF patients, PUR1900, has been designated as ... Food & Drug Administration. Under the ... development of novel drugs against important pathogens, Pulmatrix will ...
(Date:1/17/2017)...  Only nine percent of U.S. consumers believe pharmaceutical ... 16 percent believe health insurance companies do, according to ... of U.S. adults believe health care providers (such as ... hospitals (23%). "We are in the midst ... , vice president of reputation management and public affairs ...
(Date:1/17/2017)... ... , ... Pono Ola , a mind-body wellness firm on a mission ... launch of its much-anticipated Pono Board: a re-invented fitness and anti-fatigue balance board that ... a year, the patented Pono Board is the world’s only exercise balance board built ...
(Date:1/17/2017)... ... January 17, 2017 , ... Diagenode, a ... announced a collaboration with the Heidelberg University Hospital and the German Cancer Research ... following the company’s successful launch of its CATS (Capture and Amplification by ...
Breaking Biology Technology: