Navigation Links
Learning to predict sickle cell crisis and monitor treatment
Date:12/19/2013

disease to a Russian egg doll, which presents increasingly complex challenges as each layer is opened.

"It starts with the DNA, a single mutation in the gene that produces the protein hemoglobin, which carries oxygen in the blood," he explained. "The hemoglobin should be distributed homogeneously throughout the red blood cell and be able to absorb or release oxygen easily."

But with this mutation, a single amino acid in the hemoglobin protein is displaced, and as a result, the protein crystalizes and forms abnormally long chains in the cells. Similar to how water changes and forms crystals when it freezes, the protein chains change the physical and surface properties of a red blood cell, causing it to change shape and become stiff and sticky. The affected cells block blood flow.

The researchers don't know what triggers a crisis, so they are using cell stickiness as a marker of the onset. They have begun using the foundation's three-year Innovations in Clinical Research award to measure when changes in the physical properties of diseased red blood cells are associated with the painful event. For example, do sickle cells become two or three times as sticky as a normal cell when they start glomming onto one another and blocking blood vessels?

The team is also designing and building an at-home, hand-held testing device that enables patients and their doctors to monitor their blood for vital changes daily or weekly.

As designed, a patient puts a droplet of blood into the device. The blood is divided among three channels, each about half the height of a human hairthe diameter of some of the body's smallest vessels. The lining of the channels will mimic the lining of the vessels, so that interactions with the red blood cells are true to what happens inside the body.

Results come in less than 10 minutesthe time it takes for blood to flow through the channels. During that time, images and measurements of blood cells a
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Majority-biased learning
2. Awake mental replay of past experiences critical for learning
3. Dartmouth researchers are learning how exercise affects the brain
4. Songbirds learning hub in brain offers insight into motor control
5. New Genetics educational resource promotes active learning
6. New model gives hands-on help for learning the secrets of molecules
7. Learning faster with neurodegenerative disease
8. Learning from each other -- growing together
9. Sleep-deprived bees have difficulty relearning
10. Learning a new sense
11. Learning whos the top dog: Study reveals how the brain stores information about social rank
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Learning to predict sickle cell crisis and monitor treatment
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... entertainer and security consultant, Apollo Robbins for ... smart wallet.  Apollo Robbins ... 7 th , 2015, demonstrating some of his famous ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 ... the biometrics industry as Acuity Market Intelligence reports ... may finally be open. Acuity forecasts that intensifying ... devices that incorporate biometrics will drive a global ... billion biometric devices by 2020.   ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... "Micro Market Monitor: North America Perimeter Security Systems ... http://photos.prnewswire.com/prnh/20130307/600769 The North American ... CAGR of 3.6% from 2014 to 2019. Although the ... Canada is expected to grow ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... 13 May 2009: The University of Liverpool has been awarded ... the North of England. The funding comprising ... from the Northwest Regional Development Agency (NWDA) is part ... the UK research community,s access to cutting-edge equipment for DNA ...
... of their drinking water for granted, that ordinary tap ... Katzir of Tel Aviv University,s School of Physics and ... to industrial spillage, natural disaster or sabotage, the physicist ... of a building or community,s water supply in real ...
... team of Princeton University scientists may have found a ... virus. Though theoretical, the work points to ... appreciated aspect of the interaction between a virus and ... infection. By manipulating this multi-stage interactive process -- known ...
Cached Biology News:University of Liverpool awarded $3.3 million for genomics hub 2Monitoring water through a snake's eyes 2Monitoring water through a snake's eyes 3Princeton team's analysis of flu virus could lead to better vaccines 2Princeton team's analysis of flu virus could lead to better vaccines 3
(Date:12/24/2014)... LONDON , December 23, 2014 ... Review Algeria , out today and available for free ... the actors driving change and growth in the sector today. ... has scored notable successes has been in developing a homegrown ... 70 percent local production still remains some way off. A ...
(Date:12/22/2014)... 22, 2014 The Center for ... of technical training across the life sciences industry, has ... (SCDM) to provide the organization's members with discounted ... access to the more than 350 sessions across 80 ... 10% off when registering for a public course ...
(Date:12/22/2014)... GenomeDx Biosciences today announced that a new ... genomic test for prostate cancer, was able to predict ... radical prostatectomy without adjuvant therapy. Although rapid metastasis in ... tumor genomics to identify these men who have a ... advance. The study has been published online by ...
(Date:12/22/2014)... TENN (PRWEB) December 22, 2014 Fertility ... Donor Egg Bank USA , a network of ... country. Through this partnership, patients have fast access to ... in vitro fertilization, IVF . Fertility Associates of Memphis ... offer this fertility treatment option. , Dr. William ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... Winston-Salem, N.C. -- Wake Forest University has received the ... double the energy production of today,s flat cells at a ... high price to be green," said David Carroll, Ph.D., the ... where the fiber cell was developed. "This device can make ...
... ... the AOL News series, “The Nanotech Gamble,” with advice for nano-product companies on how ... ... series of AOL News articles questioning the oversight of nanotechnology product safety ( http://www.aolnews.com/category/nanotech/ ...
... ... role in Merrimack,s acquisition of Hermes Biosciences and partnership with sanofi-aventis , ... Cambridge, MA (PRWEB) April 7, ... and development of novel treatments for cancer and inflammation, today announced that William Sullivan ...
Cached Biology Technology:Wake Forest earns patent for efficient, inexpensive fiber-based solar cells 2nanoTox COO Greg King Advises Nanotech Companies to View Safety Concerns as an Opportunity to Gain Consumer Trust 2nanoTox COO Greg King Advises Nanotech Companies to View Safety Concerns as an Opportunity to Gain Consumer Trust 3Merrimack Pharmaceuticals Promotes William Sullivan to Vice President of Finance 2
... for hunting and analyzing the rare ... EST sequencing projects, microarrays, functional screenings ... well suited for the normalization of ... though, is specially developed for normalization ...
... has 20 years of expertise in the ... still offers the most powerful systems on ... to 40 000 in-microplate tests requiring incubation ... of different modules (such as worktable shaker ...
... JMP 6 delivers enhanced statistics and ... and quality improvement managers. As an ... JMP 6 simplifies statistics for novice ... needed by experts. It offers a ...
Glycerol-based mounting medium for immunofluorescence microscopy. Formulated to retard photobleaching of fluorochromes such as fluorescein and rhodamine. Product can also be used as a diluent for fl...
Biology Products: