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Leading scientist named new chair of Cell Biology at Yale
Date:6/6/2008

Rothman moved to the Department of Biochemistry at Stanford School of Medicine as an assistant professor. He continued his research at Princeton University from 1988 until 1991, when he became the founding chair of the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center in New York and vice chair of the Sloan-Kettering Institute.

In 1993, Rothman discovered a complex of vesicle membrane proteins which he implicated in membrane fusion and formulated the highly influential "SNARE hypothesis." This hypothesis posits that distinctive, complementary protein complexes known as SNARES, expressed on both vesicles and target membranes, first ensure that different classes of vesicles bind to appropriate membranes and then unleash the biochemical changes leading to fusion of vesicles with those membranes and the delivery of the vesicles' cargo to its proper destination.

He is a member of the National Academy of Sciences and the Institute of Medicine, a fellow of the American Academy of Arts and Science, and a foreign associate of the European Molecular Biology Association. He is the winner of numerous prizes in biomedicine, including Columbia's Louisa Gross Horwitz Prize and the Lasker Award for Basic Medical Research

Rothman succeeds Ira S. Mellman, a distinguished cell biologist and immunologist who was chair and Sterling Professor of Cell Biology at the School of Medicine until 2007, when he joined the biotechnology company Genentech as vice president for oncology research. Since Mellman's departure, James D. Jamieson, M.D., professor of cell biology and director of the medical school's M.D./Ph.D. Program, has served as interim chair of the Department of Cell Biology.


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Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

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