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Leading RSV researcher publishes work at Le Bonheur Children's
Date:2/14/2013

00 copies of viral RNA. Methods are scalable to large numbers of samples and capable of generating full or near full-length viral genomes from clone and clinical samples with low amounts of viral RNA, without prior sequence information and in the presence of substantial RNA contamination from the surrounding human cells.

Assessing modeled CO2 retention and rebreathing of a facemask designed for efficient delivery of aerosols to infants. International Scholarly Research Network, 2012

New medicines for infant lung diseases, such as RSV, might require deposition of these medicines directly into the lung by infants breathing an aerosol. However, efficient masks that allow the safe delivery of these aerosols without causing the infants to re-breathe their own exhaled CO2 have not previously been developed. The researchers developed a new infant aerosol delivery mask. They then evaluated the mask using computational fluid dynamic models to see if it would both efficiently deliver aerosols and whether there was retention of exhaled CO2. Because RSV (respiratory syncytial virus) primarily is an infant disease, this device could be used for delivery of aerosol treatments of RSV in infants and children.

The promise and progress of RNA interference-based antiviral therapy for respiratory viruses. Antiviral Therapy, 2012

In this invited review, DeVincenzo discusses the science behind RNA interference (RNAi) and the potential practical issues in applying this novel treatment technology against various respiratory viral diseases. DeVincenzo was the first to demonstrate that RNAi-based therapies could work in humans. One of his recent studies showed that RSV-infected lung transplant patients treated with the novel RNAi therapy improved long term lung function significantly better than did those treated with placebo, even when the patients were analyzed as long as six months later. This marks the first effective
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Contact: Hillary Welton
hillary.welton@lebonheur.org
901-287-6030
Le Bonheur Children's Hospital
Source:Eurekalert

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