Navigation Links
Lawson researchers take control of cancer
Date:7/28/2011

LONDON, ON According to the Canadian Cancer Society, one in four Canadians will die of cancer. This year alone, the disease will kill an estimated 75,000 people. With incidence rates on the rise, more cancer patients are facing grave prognoses. Fortunately, Lawson Health Research Institute's Dr. John Lewis, Dr. Ann Chambers, and colleagues have found new hope for survival. Their new study released today in Laboratory Investigation shows that maspin, a cellular protein, can reduce the growth and spread of cancer cells - but only when it is in the nucleus.

Maspin is believed to inhibit the formation, development, and spread of tumors in several aggressive cancers, including breast, ovarian, and head and neck cancers. Yet efforts to use this information to predict how cancer patients will fare have been challenging; the presence of maspin has been linked to both good and bad prognoses. Dr. Lewis, Dr. Chambers, and their team believed that this inconsistency was caused by the location of maspin in the cell, whether in the nucleus or in the cytoplasm, and sought to test this theory.

To assess the effects of maspin on tumor growth and development, they tested two aggressive cancers: a highly invasive head and neck cancer, and a breast cancer known to spread to the lymph nodes and the lungs. The team introduced two forms of maspin into the cancer cells, one that went into the nucleus and one that was blocked from the nucleus. Then they injected the cells into both chicken embryo and mouse models of cancer and asked the simple question: which one slowed the cancer down?

It turned out the answer was simple: when maspin was allowed to get into the nucleus of the cancer cells, the disease's ability to spread was significantly limited. In fact, the incidence of metastasis was lowered from 75% to 40%. When maspin was not established in the nucleus; however, this ability was reversed and cancer cells were far more likely to spread. These fi
'/>"/>

Contact: Sonya Gilpin
sonya.gilpin@lawsonresearch.com
519-685-8500 x75852
Lawson Health Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Professor Dr. Alexander (Sandy) Lawson is awarded the 2011 Herman Skolnik Award
2. U researchers look to dogs to better understand intricacies of bone cancer
3. Penn researchers help graft olfactory receptors onto nanotubes
4. U of M researchers may have discovered key to help women fight infections during pregnancy
5. Behavior 2011 to draw global contingent of more than 1,100 animal researchers to IU next week
6. U of M researchers discover gene required to maintain male sex throughout life
7. Caltech researchers create the first artificial neural network out of DNA
8. Western researchers receive $600,000 to study Prion diseases and Alzheimers
9. Researchers find potential key for unlocking biomass energy
10. Researchers present new trends in HIV cure research, call for proactive outreach programs to prevent HIV transmission in injecting drug users, and demand increased commitments to improving maternal and child health
11. E-health records should play bigger role in patient safety initiatives, researchers advocate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... -- Huntington Memorial Hospital is the first facility in ... wireless monitoring sensor to manage heart failure (HF). The ... heart failure monitoring device that has been proven to ... manage heart failure. The CardioMEMS HF System ... artery (PA) during a non-surgical procedure to directly measure ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... discovered the mother complete with her brood of some 20 ... of her soft part anatomy including legs and eyes. , ... of Leicester, Derek Siveter from Oxford, Mark Sutton from Imperial ... The team has made a digital image of the fossil ...
... Researchers at the National Institutes of Health have developed ... entire geographic regions, by eradicating the malaria parasite from ... tested only in mice, would prompt the immune system ... parasite from the digestive tract of a malaria-carrying mosquito, ...
... little mean sometimes ?especially when there's a choice bit of ... have shorter tempers than others. , Researchers in the ... of genes that affect aggression in the fruit fly Drosophila ... aggression in humans and other animals. , The study, ...
Cached Biology News:Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes 2Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes 3Fruit fly aggression studies have relevance to humans, animals 2Fruit fly aggression studies have relevance to humans, animals 3
(Date:4/21/2015)... April 21, 2015  This research service analyzes the ... pharmaceuticals and biotechnology industry. The deals are analyzed based ... observed based on the geographic region and buyer types. ... and takes into account various deal multiples such as ... the target company. Executive Summary ...
(Date:4/21/2015)... -- The North American chromatography systems market is estimated to ... Based on geography, this market has been segmented into the ... . The U.S. accounted for the largest market share, ... driving the growth of chromatography systems in these regions include ... users of chromatography techniques. The growth in the ...
(Date:4/21/2015)... 21, 2015 Research and Markets ( ... "Global Bioinformatics Market Outlook 2019" report to their ... mark of around US$ 3.7 Billion in 2013 with ... around 19% during 2015-2019 The report is ... of global developments and opportunities listed in the section ...
(Date:4/21/2015)... DUBLIN , Apr. 21, 2015 Research ... announced the addition of the "Complete 2015-16 ... report to their offering. Stem cell ... well over five decades, as stem cells have ... In addition, their unspecialized nature allows them to ...
Breaking Biology Technology:Funding Patterns in the Global Pharma and Biotech Industry 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 3Global Bioinformatics Market Outlook Report 2014-2019 - The US$ 3.7 Billion Market is Expected to Grow at a CAGR of 19% during 2015-2019 2Global Bioinformatics Market Outlook Report 2014-2019 - The US$ 3.7 Billion Market is Expected to Grow at a CAGR of 19% during 2015-2019 3Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2
... 1, 2008 HighPoint Solutions,LLC, a premier provider of ... a global biotechnology company to design and implement,a Master ... new,product launches and support its expected rapid growth over ... strive to create a holistic view of,their customers in ...
... ARLINGTON, Va., April 1, 2008 Champions,Biotechnology, Inc. ... the,development of advanced preclinical platforms and tumor specific ... today the appointment of new,Board of Directors members ... it prepares to expand its operations., Abba ...
... Dr. Roger Kenneth,Hershline, PhD, MD, the CEO of Global ... charity CureHIV.us, announces today,that he is reaching out to ... Challenges in Global Health initiative. The,monies would be used ... treatment,method, LiSAVIOR., This unique new drug is also ...
Cached Biology Technology:HighPoint Solutions Selected by Global Biotechnology Company to Provide Master Data Management Solution 2Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 2Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 3Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 4Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 5Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 6Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 7Champions Biotechnology, Inc. Appoints New Board Members and Forms Management Team 8Cure HIV Reaches Out to Foundation Community to Fund LiSAVIOR 2
6X Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Ideally suited for resolving DNA and RNA 10-1000 bases especially PCR products ranging from 100-1000 bp. Gelling temp. (4%) 27C Melting temperature 65C. EEO: 0.10 Rnase/Dnase: none detected...
Agarose Gel Loading Dye Mixture 6X...
Rabbit Anti-JNK1/SAPK pan, Polyclonal Antibody...
Biology Products: