Navigation Links
Launching a global alliance for pharmacogenomics
Date:4/14/2008

Leaders at the National Institutes of Health and the Center for Genomic Medicine in Japan have signed a letter of intent creating a Global Alliance for Pharmacogenomics. The effort aims to identify genetic factors that contribute to individual responses to medicines, including rare and dangerous side effects. The results of such work will eventually help doctors optimize the safety and effectiveness of drugs for each patient.

U.S. scientists joining the alliance are members of the NIH Pharmacogenetics Research Network, a consortium of research groups that study how genetic factors influence the way drugs work in and are handled by the body.

Japanese scientists in the alliance represent the newly created Center for Genomic Medicine, a component of the RIKEN Yokohama Institute that conducts high-throughput analyses of human genes involved in diseases and drug responses.

Signers of the agreement include the directors of three of the National Institutes of Health: Jeremy M. Berg, Ph.D., director of the National Institute of General Medical Sciences; Elizabeth G. Nabel, M.D., director of the National Heart, Lung, and Blood Institute; and John E. Niederhuber, M.D., director of the National Cancer Institute.

"By bringing together our resources, we will advance the understanding of how changes in DNA affect our responses to medicines. Thus we can begin to realize the promise of personalized medicine," said Yusuke Nakamura, M.D., Ph.D., director of the Center for Genomic Medicine at RIKEN.

We expect this international agreement to speed scientific discovery and the translation of results into improved treatments for cancer, heart disease and other serious conditions, said NIH Director Elias A. Zerhouni, M.D. Ultimately, physicians worldwide will be able to tailor the treatment of each patient--one of the great frontiers of health care today.

Initial projects will focus on:

  • Understanding genetic factors that influence the effectiveness of breast cancer treatments (aromatase inhibitors)

  • Determining the optimal length of treatment for two drugs used to treat early stage breast cancer (cyclophosphamide and either doxorubicin or paclitaxel)

  • Discovering new genetic factors linked to serious side effects from certain pancreatic cancer drugs (gemcitabine and bevacizumab)

  • Exploring how genes contribute to drug-induced long QT syndrome, an irregular heart rhythm that can cause sudden cardiac arrest

  • Working with the International Warfarin Consortium to tailor initial doses of the anti-clotting drug warfarin based on the genetic profiles of patients

A steering committee will manage the alliance and will meet twice a year to discuss progress, future directions, intellectual property issues, the approval of additional members and communication with the public. Alliance members will share their data and their research results with the scientific community.

The letter of intent is available at http://www.nigms.nih.gov/Initiatives/PGRN/GAP/. This site also includes acknowledgements of the research centers that provided DNA samples essential to perform the work.


'/>"/>

Contact: Alisa Machalek
alisa.machalek@nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Related biology news :

1. Regional nuclear conflict would create near-global ozone hole, says CU-Boulder study
2. At ACS national meeting, global initiative set to tackle water issues
3. Harmful algae taking advantage of global warming
4. Despite awareness of global warming Americans concerned more about local environment
5. Black carbon pollution emerges as major player in global warming
6. Speaker, judges set for Global Venture Challenge
7. Pew Institute teams with Chantecaille Cosmetics to protect global marine life
8. Smithsonian announces Global Forest Carbon Research Initiative
9. Will global warming increase plant frost damage?
10. Destruction of Sumatra forests driving global climate change and species extinction
11. U-M researchers release most detailed global study of genetic variation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... PA (PRWEB) , ... August 16, 2017 , ... ... taking part in sessions at the ISPE Annual Meeting and Expo , to ... San Diego Marina. The event’s theme is “Driving innovation to advance patient therapies.” , ...
(Date:8/16/2017)... Ca (PRWEB) , ... August 16, 2017 , ... ... by changing into a different cell type. Many treatments for specific cancers, such ... prominent example of targeted treatment is androgen deprivation therapy for advanced prostate cancer. ...
(Date:8/16/2017)... ... August 16, 2017 , ... Today, 3Bar Biologics ... secured $2M in funding from an impressive group of investors, including Rev1 Ventures, ... Fund. With this investment, 3Bar is broadening availability of its groundbreaking offering that ...
(Date:8/16/2017)... Mass. , Aug. 16, 2017  This year,s edition of the ... leader in life sciences workforce solutions, has made the list for the ... 5000 recognizes the nation,s fastest-growing private companies based on a set of ... 50, which includes the fastest-growing companies in the Bay State ... Inc. 5000 ...
Breaking Biology Technology: