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Launch of the EU large-scale integrating project 'BlueGenics' to combat osteoporosis
Date:12/7/2012

biomedical-relevant genes from marine animals and bacteria with the most advanced chemical synthesis and structure analysis techniques. The team led by Mller will use this research approach to develop substances up to pre-clinical testing. In this project, the Mainz team will primarily focus on substances that could be used for prophylaxis and/or therapy of osteoporosis as well as on new antimicrobial peptides and compounds with neuroprotective activity.

Mller and his research team have already demonstrated that bioactive substances can be synthesized by applying recombinant molecular biology techniques. They were able to demonstrate that defensin, a toxin and defense peptide produced by sponges, is bioactive if produced in a recombinant way. "This paves the way for exploiting the large treasure of genetic blueprints present in the world-wide oceans for human benefit," Mller said.

The European project BlueGenics brings together the leading researchers from the areas of marine genomics, biosynthesis, and chemical structure analysis. Participants of this project coordinated by Professor Dr. Werner E.G. Mller at the Mainz University Medical Center are 16 research institutions and industrial companies from Germany, France, Croatia, Portugal, Iceland, Italy, Sweden, UK, and China. According to Professor Dr. Dr. Reinhard Urban, Chief Scientific Officer of the University Medical Center, the EU is well advised to fund projects like BlueGenics: "We are practically just at the beginning to exploit marine resources, especially those from the little-explored deep sea, for biomedical purposes. However, it is now already foreseeable that research on deep-sea organisms is likely to produce remarkable results for our society."

BLUE BIOTECHNOLOGY

The so-called Blue Biotechnology is primarily concerned with the biotechnological use of marine organisms. Of particular interest are sponges and deep-sea bacteria that live under extreme condition
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Contact: Professor Dr. Werner E.G. Mller
wmueller@uni-mainz.de
49-613-139-25910
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

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