Navigation Links
Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes
Date:4/24/2009

ific parts of the body that they are meant to treat. Cardiologist Jonathan Lindner of Oregon Health and Science University will discuss his latest experiments in gene therapy, which use microscopic bubbles chemically modified to stick to the cells that line blood vessels.

This technique, ultrasound-mediated gene delivery (UMGD), exploits the properties of contrast agents, microparticles that are normally injected into the body to improve the quality of ultrasound images. In UMGD, the tiny particles are microbubbles composed of pockets of gas encapsulated by thin membranes that are coated with DNA before injection. A targeted pulse of ultrasound energy "rings" the bubbles like a bell, popping them in a specific location and releasing the DNA into the surrounding tissue.

To improve the specificity of this targeting, Lindner grafts long arm-like molecules to the outside of the bubbles. These arms, which do not interfere with the DNA attached to surface, are designed to recognize and bind to molecules on the outside of specific cells in the body, allowing the bubbles to attach to a tissue before being popped. In theory, this should improve both the specificity and efficiency of the gene therapy.

Lindner created an arm designed to attach to endothelial cells lining blood vessels. He will present data evaluating the behavior of these "targeted" bubbles in living tissue. The ability to stick these gene-laden microbubbles to the lining of blood vessels increased the amount of gene transfection. This strategy may be particularly important for delivering therapeutic DNA to the walls of blood vessels. For example, Dr. Lindner and collaborators have successfully stimulated the growth of new blood vessels using UMGD with microbubbles carrying a gene for vascular endothelial growth factor. This therapeutic use could be important for treating ischemia in patients who have had a heart attack, peripheral artery disease, or stroke.

The team is also
'/>"/>

Contact: Jason Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

2

GOOD

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Related biology news :

1. Nitrous oxide: definitely no laughing matter
2. 1 person out of every 1,000 has synaesthesia, in which an individual can smell a sound
3. The art of using science to inform ecosystem restoration in Puget Sound
4. Deep-sea sharks wired for sound
5. New 3-D ultrasound could improve stroke diagnosis, care
6. Sounding out heart problems automatically
7. If a street tree falls... what does it take to make sound policy?
8. Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively
9. Bats pick up rustling sounds against highway background noise
10. Alternative to burning: environmentally sound disposal for wood chips
11. Effects of anthropogenic sound on marine mammals -- a research strategy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... the United Kingdom, the Energy Department,s National Renewable ... have recently published a paper describing a novel ... Limnoria quadripunctata , commonly known as the gribble. ... exhibit a relatively unique ability to produce their ... break down the biomass they eat. New biomass-degrading ...
(Date:6/18/2013)... Research Council, Laboratory of Molecular Biology, has been ... Young Investigator Award. Torrent is being recognized for ... algorithm to predict antimicrobial regions in proteins. Luis ... now applying this algorithm to interrogate full genomes ... with very appealing results." , Torrent obtained ...
(Date:6/18/2013)... 18, 2013 The herbal extract of a yellow-flowered ... to increase the lifespan of fruit fly populations by ... researchers. , But it,s how Rhodiola ... that grabbed the attention of study leaders Mahtab Jafari ... works in a manner completely unrelated to dietary restriction ...
Breaking Biology News(10 mins):Novel enzyme from tiny gribble could prove a boon for biofuels research 2The American Society for Microbiology honors Marc Torrent 2Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2
... In nature, ultraviolet radiation from sunlight is not the ... and females who choose to lay their eggs in the ... amphibian species out of harm,s way most of the time, ... of the long-toed salamander received lethal doses of UV across ...
... Researchers from the p53 Laboratory of Singapore,s Agency for ... makes feasible a unique method of cancer treatment. Their work, ... Differentiation today , offers new insight on how to ... genome, , to more effectively kill cancer cells while sparing ...
... 2010) - A technique pioneered in the Tissue Engineering ... Edward V. Zegarelli Professor of Dental Medicine at Columbia ... to a three-dimensional scaffold infused with growth factor, holding ... in as soon as nine weeks once implanted. ...
Cached Biology News:Ultraviolet radiation not culprit killing amphibians, research shows 2Ultraviolet radiation not culprit killing amphibians, research shows 3Singapore scientists exploit knowledge of p53 for increasing specificity of cancer treatments 2Technique yields potential biological substitute for dental implants 2
(Date:6/19/2013)... Washington (PRWEB) June 18, 2013 A ... complex materials, costs and other trends will highlight technical ... Monterey, California this fall. In its 33rd year, the ... includes an exhibition of key suppliers, approximately 100 technical ... SPIE, the international society for optics and photonics ...
(Date:6/18/2013)... 18, 2013 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced its preliminary unaudited financial results for the fourth ... March 31, 2013. Fourth Quarter of ... quarter of fiscal 2013 increased by 33.3% to RMB133.0 ...
(Date:6/18/2013)... The human skin is the largest organ, ... human body part. Similar to the liver, or heart, the ... repair and grow. Recent reports from the mankatofreepress.com explained how ... as important as other life supporting organs. The article suggests ... cell reproduction, increase the appearance of skin, and fight off ...
(Date:6/18/2013)... 2013  regulated information — Global biopharmaceutical company UCB, ... announced the launch of a new Pledge campaign for ... The Pledge empowers the millions of Americans ... a personal commitment to demand more: greater understanding of ... and additional partial-onset seizure control.  More information is available ...
Breaking Biology Technology:‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 2China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 4China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 5China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 6China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 7China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 8China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 9China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 10China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 11China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 12China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 13Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin 2Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 2Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 3Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 4Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 5Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 6
... 4 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ... his research group at The Institute of Cancer ... testing combination treatment schedules,of reovirus and radiation in ... in,vivo. The paper, entitled "Enhanced In vitro and ...
... 2008) -- A University of Waterloo physics and astronomy ... in Science Magazine, shows how some solids behave like ... James Forrest and then-graduate student Zahra Fakhraai, take a ... substances using nanoscale technology. , They explore the properties ...
... 1 MannKind Corporation,(Nasdaq: MNKD ), focused on ... today that it will present at,the Merrill Lynch Global ... at 1:40 PM ET at the Grand Hyatt Hotel ... link to the live web cast of the,presentation in ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces Publication of Research on Combination Reovirus and Radiation Therapy 2UW paper in Science shows how some solids mimic liquids on nanoscale 2
Anti-TWIK-1 Immunogen: Purified peptide from amino acids 53-69 of human TWIK-1 (Accession number O00180)....
Monoclonal 8C2.1 is specific for Bunyavirus G1 as tested by neutralization, immunoprecipitation and immunobinding assays....
BI-1 Polyclonal Antibody Storage Temperature: -20C Shipping: gel pack Shelf-Life: 12 months...
...
Biology Products: