Sampling from the middle-aged population
The objective of CARTaGeNE was to create a public resource for research projects. Individuals aged 40 to 69 living in Montreal, Sherbrooke, Saguenay (Chicoutimi) and Quebec City metropolitan areas - were targeted. The information from the 20 000 participants will provide an accurate portrait of the Quebec metropolitan population's health and genetic diversity.
Participants were asked to complete a health questionnaire and interview with a nurse, and to give samples of urine, serum and blood. A small fraction of the samples will be used for initial analyses but most will be stored in the GQ-CAURC Biobank. Physical measurements, such as weight, waist and hips circumference, bone density, arterial pressure and stiffness were also taken. Participants were also invited during the consent process to indicate if they wanted to be contacted again or if they wish to participate in the CARTaGENE genealogical option by answering another questionnaire at home. Bartha Knoppers, a McGill University Professor of Medicine and Director of the HumGen project, and Claude Laberge, a University of Laval Genetics professor were the the original principal investigators of the project and are members of the CARTaGENE team.
"Our next steps are to enhance the data," says Awadalla. "Working with our sister biobanks across Canada, we are following up participants to evaluate individual lifestyle impacts on health such as nutrition, residential and occupational history. We are also exploring how environment impacts how individuals genes are regulated, and the impact of this variation on chronic disease."
Randomly recruiting participants is key to understanding how the genome of each human being interacts with the environment to determine ones health status. The science of genomi
|Contact: Julie Gazaille|
University of Montreal