Navigation Links
Largest ever study of genetics of common disease just got bigger
Date:4/13/2008

DNA samples from 120,000 people are to be analysed in a 30 million follow up to last year's Wellcome Trust Case Control Consortium (WTCCC), the largest ever study of the genetics behind common diseases. The seven-fold increase in the number of samples to be analysed will allow researchers to look at a 25 diseases as well as studying the genetics of learning in children and individuals' responses to statins.

Funded by the Wellcome Trust, this new series of genome-wide association studies will be one of the most ambitious initiatives ever undertaken, bringing together leading research groups from at least 60 institutions internationally (including over 20 from the UK). Over the next two years, working in collaboration with the WTCCC or independently, the research teams are expected to analyse as many as 120 billion pieces of genetic data in the search for the genes underlying diseases such as multiple sclerosis, schizophrenia and asthma.

Researchers will examine between 500,000 and 1 million variants (SNPs) per sample as well as a comprehensive set of copy number variants (CNVs). Both SNPs and CNVs are responsible of the individual variation in our genomes.

"We have now entered a new era of large-scale genetics unthinkable even a few years ago," says Professor Peter Donnelly from the University of Oxford, who will chair the consortium. "Breakthroughs in our understanding of the human genome and rapid advances in sequencing technology mean that we are able to do very powerful analysis much faster and on a vastly bigger scale than ever before."

When the results of the WTCCC were announced in 2007, it was seen as a major breakthrough for medical science and was selected as one of the scientific highlights of the year by a number of the most prestigious scientific journals, including Nature and The Lancet. It identified a number of new genes and regions of the human genome which increase peoples susceptibility to or protect them from particular diseases.

Dr Mark Walport, Director of the Wellcome Trust, says: It is now possible to unlock the genetics of common diseases. Although genetics tells only part of the story of disease, it can provide valuable and often unexpected insights that offer the promise of developing new treatments for these often very complex diseases.

The research has been made possible by advances in progress in improved understanding of human genome variants, pioneered by the Wellcome Trust Sanger Institute at Hinxton, Cambridge. The Institute will devote a large part of its high-throughput genotyping pipeline headed by Dr Panos Deloukas to test many of the DNA samples. Most of the data analysis will be undertaken at the Wellcome Trust Centre for Human Genetics, University of Oxford.

The Sanger Institute is bringing the power of its skills in genetic analysis to tackle common disease, to provide leadership, expertise and resources where they can make a difference," says Professor Leena Peltonen, who was appointed Head of Human Genetics at the Wellcome Trust Sanger Institute last year. "Our redefined strategy and joint expertise of human genetics faculty will ensure we deliver yet more ground-breaking results in clinically relevant areas."


'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Related biology news :

1. Largest study to investigate risk factors of autism to begin enrolling families
2. Single-largest biodiversity survey says primary rainforest is irreplaceable
3. Worlds largest investor coalition seeks further disclosure on climate change and shareholder value
4. Worlds largest marine protected area created in Pacific Ocean
5. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. Study begins to reveal clues to the cause and progression of sepsis
8. Clones on task serve greater good, evolutionary study shows
9. New study warns limited carbon market puts 20 percent of tropical forest at risk
10. New study examines how rearing environment can alter navigation
11. Study links cat disease to flame retardants in furniture and to pet food
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... Nov. 30, 2016  higi SH llc (higi) ... initiative targeting national brands, industry thought-leaders and celebrity ... respective audiences for taking steps to live healthier, ... in 2012, higi has built the largest self-screening ... 38 million people who have conducted over 185 ...
(Date:11/29/2016)... 29, 2016 Nearly one billion matches per second ... ... DERMALOG is Germany's ... efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification ...
(Date:11/22/2016)... , November 22, 2016 According to the ... IRIS, Palm Print, Face, Vein, Signature, Voice), Multi-Factor), Component (Hardware and Software), ... published by MarketsandMarkets, the market is expected to grow from USD 10.74 ... CAGR of 16.79% between 2016 and 2022. ... ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... Diego, CA (PRWEB) , ... December 01, 2016 , ... ... data from its Phase I/II clinical trials for AC0010 at the World Conference on ... forward to providing an update on the phase I/II clinical trials for AC0010 in ...
(Date:12/2/2016)... ... 01, 2016 , ... The Conference Forum has announced that the 3rd annual ... place on February 1-3, 2017 at the Roosevelt Hotel in New York City. Led ... a unique 360-degree approach, which addresses the most up-to-date information regarding business aspects, clinical ...
(Date:12/2/2016)... ... December 02, 2016 , ... Robots will storm the Prudential ... December 3rd, 2016. The event, which is held on the United Nations International Day ... with Disabilities back into the workplace. Suitable Technologies is partnering with NTI to showcase ...
(Date:11/30/2016)... ... November 30, 2016 , ... BEI Kimco, a brand of ... flexure design that ensures high alignment accuracy by preventing unwanted shaft rotation. The ... where extreme precision is required, such as in medical equipment, laboratory instrumentation, clean ...
Breaking Biology Technology: