Navigation Links
Largest ever epigenetics project launched
Date:9/6/2010

One of the most ambitious large-scale projects in Human Genetics has been launched today: Epitwin will capture the subtle epigenetic signatures that mark the differences between 5,000 twins on a scale and depth never before attempted, providing key therapeutic targets for the development of drug treatments.

The project is a collaboration between TwinsUK, a leading twin research group based at King's College London, and BGI, one of the world's largest genomic organisations headquartered in Shenzhen, China. Epigenetics is the most cutting edge emerging field in Genetics, which explores how the actions of genes can be temporarily modified by chemical reactions that may occur either at random or by lifestyle or diet. This effect may last several generations.

The plan is to look at the methylation patterns of 20 million sites (called CpG islands) in the DNA of each twin and compare them with the patterns in the co-twin. Rather than looking at similarities as in previous studies, the team will be looking for differences that explain why many identical twins don't develop the same diseases. Initially the team will focus on obesity, diabetes, allergies, heart disease, osteoporosis and longevity, but the method can be applied to every common trait or disease.

'Finding the crucial differences between twins will lead us to the key genes that are being turned on and off, and so to the cause of disease, with great potential to find key targets for drug treatments,' says Tim Spector, Director of TwinsUK and Professor of Genetic Epidemiology at King's College London, who is leading the project. 'The fact that twins are such a marvellous natural experiment, combined with the hundreds of disease details and traits on the twins that we have collected over 17 years, offer a unique study opportunity. So far this type of study has only been attempted on a handful of twins, so we want to scale it up one thousand fold.'

The Executive Director o
'/>"/>

Contact: Melanie Haberstroh
melanie.haberstroh@kcl.ac.uk
44-020-784-83076
King's College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. U-M researchers receive largest single collection of psoriasis DNA samples
2. Worlds largest meeting of ear, nose and throat doctors to convene in Boston Sept. 26-29, 2010
3. New Tree of Life established for one of the largest groups of bacteria
4. Actress Glenn Close to address stigma of mental illness at worlds largest brain science meeting
5. Nations largest organization of ecologists offers expert database
6. The largest Last Supper
7. Experts gather to solve mystery of largest recorded die-off of great whales
8. Largest gene study of childhood IBD identifies 5 new genes
9. Largest-ever database for liver proteins may lead to treatments for hepatitis
10. The largest bat in Europe inhabited northeastern Spain more than 10,000 years ago
11. Worlds largest marine protected areas sign partnership agreement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... 17, 2015  Synaptics Inc. (NASDAQ: SYNA ... announced that Xiaomi, one of the world,s largest ... ClearPad ® family of capacitive touchscreen solutions ... (DDICs) for its latest smartphones, the Xiaomi Mi ... full in-cell display solutions and DDICs in discrete ...
(Date:6/16/2015)... 16, 2015 Fingerprint Cards (FPC) raises ... it will amount to at least 340 MSEK to that ... rapid increase in market growth and orders received the revenue ... that revenue for 2015 will exceed 1,500 MSEK to an ... 2,200 MSEK. Due to receipt of orders of ...
(Date:6/11/2015)... Daon, a global leader in mobile ... Mobile Authentication Platform v4.0 has been FIDO Certified™.  ... industry consortium launched in 2013 to revolutionize online ... In order to receive certification, a company,s products ... tests that measure compliance and ensure interoperability among ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... N.H. Researchers from the University of New Hampshire ... organic dairy farmers better produce and market their milk. ... Agriculture (USDA) National Institute of Food and Agriculture (NIFA) ... Cornell, and the USDA, well as UNH, the research ...
... proteins that regulate nerve cells and assist in overall brain function ... of a stroke, the leading cause of disability and third leading ... recent study published in the Journal of Neuroscience , Bonnie ... Arts and Sciences, says the new research indicates that increased production ...
... Elsevier, the world-leading publisher of scientific, technical ... that its 2012 eBook Frontlist collections are available ... platform for scientific content. This release marks a ... the eBook collection on SciVerse ScienceDirect. The 2012 ...
Cached Biology News:UNH-led project to boost Northeast organic dairy industry 2UNH-led project to boost Northeast organic dairy industry 3Rutgers neuroscientist says protein could prevent secondary damage after stroke 2Elsevier announces new 2012 Frontlist eBooks collection on SciVerse ScienceDirect 2
(Date:7/1/2015)... 2015 Isagenix International, a leading global health ... three Silver, and three Bronze Stevie® Awards at the ... Chicago this month.The American Business ... program in the U.S. "Winning is ... developing leaders, cultivating talent, creating a unified team, and ...
(Date:7/1/2015)... ... 2015 , ... Apex Therapeutics announced today that company CEO, David Broecker provided ... , The presentation took place on Tuesday, June 16 and provided an update on ... for the treatment of pancreatic cancer. A copy of the company overview can ...
(Date:6/30/2015)... KYOTO, Japan , July 1, 2015 R-Japan ... Act on the Safety of Regenerative Medicine from the Ministry ... Welfare on June 29, 2015. The fact ... cell processing facility through the auditing from Pharmaceuticals and Medical ... filing the application, allows it to provide stem cell manufacturing ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... is hosting a webinar to provide advanced scientific research into new classes of ... science and energy. Touted as 'the wonder material of the 21st Century' ...
Breaking Biology Technology:Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4
... March 13 Sigma-Aldrich (Nasdaq: SIAL ) ... the Republic of Chile to directly serve research and ... acquired Sigal Ltda, its primary distributor in Chile, and ... future growth in the country. "Building on ...
... CITY, March 13 Prolexys Pharmaceuticals announced today the publication ... a role in the aging process of humans. The ... from simple animals which confer long life in those species. ... to interact with other proteins in a large atlas of ...
... will be exploring answers to energy security questions during a daylong ... Greater Houston Partnership once again takes center stage in leading the ... Paths to Energy Security." , ... Houston (PRWEB) March ...
Cached Biology Technology:Sigma-Aldrich Acquires Sigal Ltda and Expands Operations in Chile 2Proteomics Study Reveals That Genes Involved in Invertebrate Longevity Have Surprising Parallels in Humans. 2Proteomics Study Reveals That Genes Involved in Invertebrate Longevity Have Surprising Parallels in Humans. 3Greater Houston Partnership to Lead Energy Security Discussion 2
... sequencing of individual research samples, including PCR ... Agencourt's world-class, high performance sequencing pipeline processes ... The key benefits of Agencourt's QuickLane ... 48 hour sample turnaround, industry leading sequence ...
A component of the Acridinium protein labeling kit....
... Affinity Life Sciences can provide custom microplate coating using ... washes a variety of plate formats. We can also accommodate ... volume range of 0.5-320 L):, , ... 96 well microplate, ...
... HRP Conjugation Kits are based on ... that are consistent and reproducible. This ... conjugate your protein or antibody, including ... buffer. Activated HRP is supplied ...
Biology Products: