Navigation Links
Largest ever Alzheimer's genome study unveils dementia mysteries
Date:9/6/2009

British scientists have discovered two new genes associated with Alzheimer's disease, while French colleagues uncovered a third. The results, from the largest ever Alzheimer's genome-wide association study (GWAS) involving 16,000 individuals, are published in Nature Genetics. They are the first new genes found to be associated with the common form of Alzheimer's disease since 1993.

The Alzheimer's Research Trust spoke of "a leap forward for dementia research", the MRC's Sir Leszek Borysiewicz praised "a huge step towards achieving an earlier diagnosis of Alzheimer's", and the Welsh First Minister Rhodri Morgan hailed the Cardiff-led study as "a real feather in the cap of Welsh science".

The study was funded by the Wellcome Trust, Medical Research Council, Alzheimer's Research Trust and Welsh Assembly Government among others. The UK-led research involved scientists from universities in Cardiff, London, Cambridge, Nottingham, Southampton, Manchester, Oxford, Bristol and Belfast, who collaborated with Irish, German, Belgian, Greek and American institutions.

Previously only one gene, APOE4, had been associated with Alzheimer's disease. This study reveals two further genes, CLU and PICALM, are related to the disease. This is expected to provide scientists with a much clearer route to developing new treatments.

The paper's lead-author, Prof Julie Williams, Chief Scientific Adviser to the Alzheimer's Research Trust, said: "Both CLU and PICALM highlight new pathways that lead to Alzheimer's disease. The CLU gene produces clusterin which normally acts to protect the brain in a variety of ways. Variation in this gene could remove this protection and contribute to Alzheimer's development. PICALM is important at synapses - connections between brain cells - and is involved in the transport of molecules into and inside of nerve cells, helping form memories and other brain functions. We know that the health of synapses is closely
'/>"/>

Contact: Andrew Scheuber
ascheuber@alzheimers-research.org.uk
44-774-827-2171
Alzheimer's Research Trust
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Worlds largest ocean observatory takes shape
2. One of the Largest Wendys(R) Franchisees, Tar Heel Capital, Reduces Fraud and Slashes Costs with DigitalPersona
3. Scientists identify worlds largest leatherback turtle population
4. Disappearing act of worlds second largest fish explained
5. DOE makes largest Danforth Campus research award in history
6. Worlds largest snake discovered in fossilized rainforest
7. Largest prehistoric snake on record discovered in Colombia
8. At 2,500 pounds and 43 feet, prehistoric snake is the largest on record
9. Tips for making a green holiday from the worlds largest scientific society
10. Less than one month to opening of world’s largest global congress on osteoporosis
11. Paradigm Tactical Products to be Largest Distributor of Metal/Radiation Detection Wands in United States
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... each year, but its deep-blue waters host the ... alien species, including fish, crustaceans, and algae are ... In the open-access journal Frontiers in Marine ... data from a new information system developed by ... of alien species has changed the native biodiversity ...
(Date:9/30/2014)... as something that we enjoy when we visit a national ... think of ourselves as a part of nature? A bird,s ... house? , The answers to these questions reflect different ... speech and in cultural artifacts. , A new Northwestern University ... Indian Center of Chicago and the Menominee tribe of Wisconsin, ...
(Date:9/30/2014)... the popular attention of both children and aquarium hobbyists ... as dehydrated eggs, these tiny brine shrimp readily hatch, ... of salt water. , Physicists, though, are interested ... vertically migrate in large groups in response to changing ... and retreating deeper during the day. , Two researchers ...
Breaking Biology News(10 mins):Biodiversity in the Mediterranean is threatened by alien species 2The cultural side of science communication 2Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2
... Boulder, CO and Ipswich, MA (July 27, 2011) ... announce today that they have entered into an exclusive ... critical and unique reagents in several current and future ... products. SOMAmers are specific protein binding reagents ...
... CORVALLIS, Ore. Chemists at Oregon State University have ... ago to create what may be the world,s best blue ... other colors, with significant potential in the paint and pigment ... orange pigment appropriate for the OSU Beavers whose team ...
... bypass surgery alters people,s food preferences so that they ... study led by scientists at Imperial College London. The ... Integrative, and Comparative Physiology , suggest a new mechanism ... long-term weight loss. A growing number of obese ...
Cached Biology News:Pigment discovery expanding into new colors 2Gastric bypass surgery changes food preferences 2
(Date:10/1/2014)... -- Pfanstiehl has announced the launch of cGMP-produced, ... USA under ICH Q7 ... playing a key role in protein glycosylation.  Now, ... media supplementation with mannose can improve overall culture ... Dr. Christopher Wilcox , VP, Business Development ...
(Date:10/1/2014)... (PRWEB) September 30, 2014 In ... cost-effective tools to address sales, training and consumer ... has developed innovative mobile applications to turn their ... the agency’s latest customized mobile app creations, are ... . , In partnership with Toyota, StudioPMG created ...
(Date:10/1/2014)... Francisco, California (PRWEB) October 01, 2014 ... from the National Science Foundation to expand their bioCAD/CAM ... to build and modify DNA. The Small Business Innovation ... commercialize the “j5” technology under exclusive license from the ... Joint BioEnergy Institute , an LBNL laboratory that ...
(Date:9/30/2014)... , The researchers etched ... layer. Quantum dots are small structures that spontaneously emit light ... pulse is fired at the photonic crystal, its refractive index ... the electromagnetic field around it. This change can speed up ... As soon as the refractive index recovers its usual value, ...
Breaking Biology Technology:Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Digital Agency Studio PMG Launches New Case Studies on Website 2TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Ultrafast remote switching of light emission 2
... 2008 Rankings Include 170 Hospitals and Medical Centers in 16 ... 19 Hospitals Included ... Media Group today,announced the 2008 publication of America,s Best Hospitals, ... newsstands,Monday, July 14., Authoritative and influential, the 2008 America,s ...
... ST. LOUIS, July 11 Sigma-Aldrich Corporation,(Nasdaq: ... to discuss second,quarter results on Wednesday, July 23, ... Time)., This call is being webcast by ... at http://www.sigma-aldrich.com ., The webcast ...
... PURE Bioscience (Nasdaq:,PURE) announced today that Michael L. ... the closing bell at the NASDAQ Stock Exchange at,4:00 ... return to the,NASDAQ stock market on April 2, 2008., ... of the closing ceremony will begin at 3:50 PM ...
Cached Biology Technology:U.S. News Media Group Releases 19th Edition of America's Best Hospitals 2U.S. News Media Group Releases 19th Edition of America's Best Hospitals 3Sigma-Aldrich Corporation's 2nd Quarter 2008 Earnings Conference Call 2PURE Bioscience CEO to Ring NASDAQ Closing Bell 2PURE Bioscience CEO to Ring NASDAQ Closing Bell 3
Goat polyclonal to HA1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: TLGSCRERQPEFV from the C terminus of human HA1. Entrez GeneID: 23526 Swiss Protein ID: O78181...
... Capture high-resolution chemiluminescent and bioluminescent ... High-sensitivity camera is cooled to subzero ... dynamic range for high quality images ... light-tight cabinet provides optimum conditions for ...
Goat polyclonal to Sarcosine Oxidase ( Abpromise for all tested applications). Antigen: Microbial Sarcosine Oxidase. Entrez Gene ID: 51268 Swiss Protein ID: Q6IAJ9...
odz, odd Oz/ten-m homolog 1 [Source:RefSeq_peptide;Acc:NP_055068] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: