Navigation Links
Large-scale study focuses on heavy smokers
Date:8/25/2014

It is a fact that smoking is harmful and associated with deadly diseases such as cancer and cardiovascular disease. Researchers also know that smokers die earlier than non-smokers. But a study that sheds light on the direct causal relationship between smoking and mortality by investigating genes has never been published before:

We have studied 55,568 individuals, including 32,823 smokers who we followed for ten years. 3,430 died during this period. The epidemiological studies were supported by genetic analyses, and the conclusion is clear. Smoking is associated with premature death, and heavy smokers have a 75 percent higher risk of dying than never-smokers of the same age. This may not come as a surprise, but it is actually the first time that this type of study which presents a direct causal relationship between smoking and mortality has been carried out, says Professor and chief physician Brge Nordestgaard from the University of Copenhagen and Copenhagen University Hospital.

Smoking gene increases tobacco consumption

The researchers have also studied a special gene variant that impacts heavy smoking: The smoking gene has no influence on whether you start or quit smoking. But if you do smoke, the gene will make you smoke more. People who have inherited the gene variant from both their parents smoke 20 percent more than those without the special gene variant.

There is a lot to suggest that you can be genetically predisposed to heavy smoking. Smokers carrying a special genetic mutation have a higher tobacco consumption and they are more affected by smoking, e.g. by having higher blood nicotine levels. They quite simply smoke more convincingly which is, of course, very harmful for their health and they have a 14 percent higher risk of dying before other smokers, says Brge Nordestgaard.

The study is based on the Copenhagen General Population Study and was carried out together with, amongst others, Line Rode, MD, PhD, at Copenhagen University Hospital.

Read more in the International Journal of Epidemiology.


'/>"/>

Contact: Børge Nordestgaard
Boerge.Nordestgaard@regionh.dk
45-30-28-72-63
University of Copenhagen The Faculty of Health and Medical Sciences
Source:Eurekalert

Related biology news :

1. Scientists provide first large-scale estimate of reef shark losses in the Pacific Ocean
2. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
3. Bay Area PV Consortium announces $7.5 million in grants to lower the cost of large-scale solar
4. Launch of the EU large-scale integrating project BlueGenics to combat osteoporosis
5. Can algae-derived oils support large-scale, low-cost biofuels production?
6. Medical societies to launch large-scale study on vein filter use
7. The large-scale EU project EU BON: Towards integration with its global counterpart GEO BON
8. Genes behind obesity mapped in large-scale study
9. Large-scale biodiversity is vital to maintain ecosystem health
10. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
11. Major meeting to propose large-scale solutions to landscape challenges in Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Kapstone Medical is proud ... successes helping medical technology companies and inventors develop and safeguard their latest innovations. ... engineering firm with a portfolio of clients in the United States and around the ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... Asian exhibitions for analytical and scientific instruments. This year’s symposium, organized by the ... in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss novel ionization ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea arabica ... biotic and abiotic factors. During this educational webinar, participants will learn about the ... as gain a better understanding of how genomics is important for coffee breeding ...
Breaking Biology Technology: