Navigation Links
Large-scale study focuses on heavy smokers

It is a fact that smoking is harmful and associated with deadly diseases such as cancer and cardiovascular disease. Researchers also know that smokers die earlier than non-smokers. But a study that sheds light on the direct causal relationship between smoking and mortality by investigating genes has never been published before:

We have studied 55,568 individuals, including 32,823 smokers who we followed for ten years. 3,430 died during this period. The epidemiological studies were supported by genetic analyses, and the conclusion is clear. Smoking is associated with premature death, and heavy smokers have a 75 percent higher risk of dying than never-smokers of the same age. This may not come as a surprise, but it is actually the first time that this type of study which presents a direct causal relationship between smoking and mortality has been carried out, says Professor and chief physician Brge Nordestgaard from the University of Copenhagen and Copenhagen University Hospital.

Smoking gene increases tobacco consumption

The researchers have also studied a special gene variant that impacts heavy smoking: The smoking gene has no influence on whether you start or quit smoking. But if you do smoke, the gene will make you smoke more. People who have inherited the gene variant from both their parents smoke 20 percent more than those without the special gene variant.

There is a lot to suggest that you can be genetically predisposed to heavy smoking. Smokers carrying a special genetic mutation have a higher tobacco consumption and they are more affected by smoking, e.g. by having higher blood nicotine levels. They quite simply smoke more convincingly which is, of course, very harmful for their health and they have a 14 percent higher risk of dying before other smokers, says Brge Nordestgaard.

The study is based on the Copenhagen General Population Study and was carried out together with, amongst others, Line Rode, MD, PhD, at Copenhagen University Hospital.

Read more in the International Journal of Epidemiology.


Contact: Børge Nordestgaard
University of Copenhagen The Faculty of Health and Medical Sciences

Related biology news :

1. Scientists provide first large-scale estimate of reef shark losses in the Pacific Ocean
2. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
3. Bay Area PV Consortium announces $7.5 million in grants to lower the cost of large-scale solar
4. Launch of the EU large-scale integrating project BlueGenics to combat osteoporosis
5. Can algae-derived oils support large-scale, low-cost biofuels production?
6. Medical societies to launch large-scale study on vein filter use
7. The large-scale EU project EU BON: Towards integration with its global counterpart GEO BON
8. Genes behind obesity mapped in large-scale study
9. Large-scale biodiversity is vital to maintain ecosystem health
10. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
11. Major meeting to propose large-scale solutions to landscape challenges in Africa
Post Your Comments:
(Date:11/12/2015)... -- A golden retriever that stayed healthy despite having the ... a new lead for treating this muscle-wasting disorder, report ... MIT and Harvard and the University of São Paolo ... Cell, pinpoints a protective gene that boosts muscle ... Boston Children,s lab of Lou Kunkel , PhD, ...
(Date:11/10/2015)... , Nov. 10, 2015 ... behavioral biometrics that helps to identify and verify ... Signature is considered as the secure and accurate ... identification of a particular individual because each individual,s ... accurate results especially when dynamic signature of an ...
(Date:10/29/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that it has ... as one of only three finalists for a ... and Growing" category. The Tekne Awards honor Minnesota ... technology innovation and leadership. iMedNet™ eClinical ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna ... announced today that the remaining 11,000 post-share consolidation ... Purchase Warrants (the "Series B Warrants") subject to ... exercised on November 23, 2015, which will result ... After giving effect to the issuance of such ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... are paramount. Insertion points for in-line sensors can represent a weak spot where ... InTrac 781/784 series of retractable sensor housings , which are designed to tolerate ...
(Date:11/24/2015)... Vancouver, BC (PRWEB) , ... November 24, 2015 ... ... to our customer, OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology ... Creation Technologies’ Texas facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device ...
(Date:11/24/2015)... 24, 2015 Capricor Therapeutics, Inc. ... the discovery, development and commercialization of first-in-class therapeutics, today ... Officer, is scheduled to present at the 2015 Piper ... a.m. EST, at The Lotte New York Palace Hotel ... . --> . ...
Breaking Biology Technology: