Navigation Links
Large-scale analysis identifies new genetic alterations associated with height
Date:12/30/2010

A large collaborative study has added to the growing list of genetic variants that determine how tall a person will be. The research, published by Cell Press on December 30 in the American Journal of Human Genetics, identifies uncommon and previously unknown variants associated with height and might provide insight into the genetic architecture of other complex traits.

Although environmental variables can impact attained adult height, it is clear that height is primarily determined by specific alleles that an individual inherits. Height is thought to be influenced by variants in a large number of genes, and each variant is thought to have only a small impact on height. However, the genetics of height are still not completely understood. "All of the variants needed to explain height have not yet been identified, and it is likely that the additional genetic variants are uncommon in the population or of very small effect, requiring extremely large samples to be confidently identified," explains Dr. Hakon Hakonarson from The Children's Hospital of Philadelphia.

To search for genetic variants associated with adult height, researchers performed a complex genetic analysis of more than 100,000 individuals. "We set out to replicate previous genetic associations with height and to find relevant genomic locations not previously thought to underpin this complex trait" explains Dr. Brendan Keating, also from The Children's Hospital of Philadelphia. The authors report that they identified 64 height-associated variants, two of which would not have been observed without such a large sample size and the inclusion of direct genotyping of uncommon single-nucleotide polymorphisms (SNPs). A SNP is a variation in just one nucleotide of a genetic sequence; think of it as a spelling change affecting just one letter in an uncommonly long word.

These results suggest that genotyping arrays with SNPs that are relatively rare and occur in less than 5% of the population have the ability to capture new signals and disease variants that the common SNP arrays missed (i.e., 30 new signals in this study), as long as sample sizes are large enough. These low-frequency variants also confer greater effect sizes and, when associated with a disease, could be a lot closer to causative than more common variants. "The increased power to identify variants of small effect afforded by large sample size and dense genetic coverage including low-frequency SNPs within loci of interest has resulted in the identification of association between previously unreported genetic variants and height," concludes Dr. Keating.


'/>"/>

Contact: Elisabeth Lyons
enlyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related biology news :

1. Lack of large-scale experiments slows progress of environmental restoration
2. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
3. Pollution at home lurks unrecognized, instead attributed to large-scale environmental disasters
4. Researchers solve piece of large-scale gene silencing mystery
5. Success for first outdoor, large-scale algae-to-biofuel research project in Nevada
6. New theory gives more precise estimates of large-scale biodiversity
7. Sweet corn study provides large-scale picture of better fields
8. WCC Webinar on De-Duplication in Large-Scale Identity Systems
9. Powerful genome barcoding system reveals large-scale variation in human DNA
10. BIO-key® Awarded Additional Large-Scale Fingerprint Biometric Contract
11. Human Microbiome Project awards funds for technology development, data analysis and ethical research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased ... test was determined to be appropriate as a screening test at dairies and farms ... Charm EZ system, and the Charm EZ Lite system. These systems are a combination ...
(Date:6/20/2017)... , ... June 20, 2017 , ... Biologist Dawn Maslar ... While researching her latest book, Men Chase, Women Choose: The Neuroscience of Meeting, Dating, ... has a physiological effect on men. ”The logical next step, in my estimation, was ...
(Date:6/20/2017)...  Kibow Biotech Inc., a pioneer in developing "Enteric ... a new patent covering a unique method for preventing ... and Trademark Office on May 23 rd 2017. ... Bio award in 2014 in San Diego, ... to chronic disease. Renadyl™, the first and only dietary ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... Do More ... the transition from being a trusted supplier in the weighing industry, to extending its ... extractions, ELISA essays, enzyme reactions, immunoassays, hybridizations and more, allowing for its customers ...
Breaking Biology Technology: