Navigation Links
Large-scale analysis identifies new genetic alterations associated with height
Date:12/30/2010

A large collaborative study has added to the growing list of genetic variants that determine how tall a person will be. The research, published by Cell Press on December 30 in the American Journal of Human Genetics, identifies uncommon and previously unknown variants associated with height and might provide insight into the genetic architecture of other complex traits.

Although environmental variables can impact attained adult height, it is clear that height is primarily determined by specific alleles that an individual inherits. Height is thought to be influenced by variants in a large number of genes, and each variant is thought to have only a small impact on height. However, the genetics of height are still not completely understood. "All of the variants needed to explain height have not yet been identified, and it is likely that the additional genetic variants are uncommon in the population or of very small effect, requiring extremely large samples to be confidently identified," explains Dr. Hakon Hakonarson from The Children's Hospital of Philadelphia.

To search for genetic variants associated with adult height, researchers performed a complex genetic analysis of more than 100,000 individuals. "We set out to replicate previous genetic associations with height and to find relevant genomic locations not previously thought to underpin this complex trait" explains Dr. Brendan Keating, also from The Children's Hospital of Philadelphia. The authors report that they identified 64 height-associated variants, two of which would not have been observed without such a large sample size and the inclusion of direct genotyping of uncommon single-nucleotide polymorphisms (SNPs). A SNP is a variation in just one nucleotide of a genetic sequence; think of it as a spelling change affecting just one letter in an uncommonly long word.

These results suggest that genotyping arrays with SNPs that are relatively rare and occur in less than 5% of
'/>"/>

Contact: Elisabeth Lyons
enlyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Lack of large-scale experiments slows progress of environmental restoration
2. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
3. Pollution at home lurks unrecognized, instead attributed to large-scale environmental disasters
4. Researchers solve piece of large-scale gene silencing mystery
5. Success for first outdoor, large-scale algae-to-biofuel research project in Nevada
6. New theory gives more precise estimates of large-scale biodiversity
7. Sweet corn study provides large-scale picture of better fields
8. WCC Webinar on De-Duplication in Large-Scale Identity Systems
9. Powerful genome barcoding system reveals large-scale variation in human DNA
10. BIO-key® Awarded Additional Large-Scale Fingerprint Biometric Contract
11. Human Microbiome Project awards funds for technology development, data analysis and ethical research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... Ariz. , Dec. 2, 2014 As ... hand readers, Inception Technologies is pleased to announce the ... easier for customers to collect the workforce data that ... problems that have been left by existing readers. Many ... user interface, connectivity and modern technology. Older models force ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014 Strict ... driver efficiency are piloting the North American and European ... of accidents growing, gesture recognition systems that are intuitive ... a mark in the industry. New ... Automotive Gesture Recognition Market in Europe ...
(Date:11/18/2014)... Nov. 18, 2014  The Secure Identity & ... today jointly announce the formation of The Airport ... its Identity and Biometric Entry and Exit ... received official support from BORDERPOL, the international non-profit ... and provide expertise regarding border security, traveler and ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Southwestern Medical Center have found an enzyme vital for controlling ... process when it works right, but malignant in a variety ... examining tissue from cancer patients to try to determine how ... “We think this gene will really be a hot spot ...
... to find alternative fuel sources are lighting a fire under ... , Texas Senate Bill 20, signed this week by Gov. ... biomass can be used. The new law requires more renewable ... years. , Combining consumer energy needs and agriculture industry trends ...
... by biologists at the University of California, Berkeley, has found ... reaction that leads to the increased expression of a marker ... to be published July 3 in an advanced online issue ... the natural killer (NK) cells - which are able to ...
Cached Biology News:UT Southwestern researchers discover master switch in cell death 2Researchers find ways to turn manure into power 2Researchers find ways to turn manure into power 3New study finds how cells with damaged DNA alert the immune system 2New study finds how cells with damaged DNA alert the immune system 3
(Date:12/24/2014)... Dec. 23, 2014 China Biologic Products, ... a leading fully integrated plasma-based biopharmaceutical company in ... its majority-owned subsidiary, Shandong Taibang Biological Products Co. ... from the China Food and Drug Administration (the ... As previously disclosed in the Company,s public filings, ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 /PRNewswire/ ... study of mazindol in children with attention deficit/hyperactivity disorder ... December 2014 . The paper, titled ... attention deficit/hyperactivity disorder" ( Konofal et al, ... eCollection 2014 ) shows that mazindol might be ...
(Date:12/22/2014)... SAN DIEGO , Dec. 22, 2014 ... that the Decipher Prostate Cancer Classifier, a genomic test ... disease in node-negative, high-risk men managed by radical prostatectomy ... with radical prostatectomy is relatively uncommon, using tumor genomics ... form of metastatic disease is an important advance. The ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... of 2008 R&D 100 Awards Now Online, ROCKAWAY, ... for the 8th Annual Innovator of the Year and ... who exemplify the,ideals of R&D in academia, industry, and ... online with ten finalists,-- five scientists and five innovators ...
... SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company,announces that ... on September 24, 2008, the Company has changed its ... plc,s ticker symbols on the London Stock Exchange and ... and American Depositary,Shares will remain unchanged., Notes to ...
... that Dr. Francis Stoessel, a leading Process Safety Consultant ... Keynote Speaker in the Process Safety and Thermal Hazard ... ... Columbia, MD (PRWEB) October 1, 2008 -- ...
Cached Biology Technology:2008 R&D Innovator of the Year & Scientist of the Year Finalists Announced 2
... GeneBLAzer cell-based assays utilize the ... of the negatively charged fluorescent beta-lactamase ... esters readily enter the cell, where ... converts them into their negatively charged ...
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
... the membrane-permeant ester forms (CCF2-AM and ... beta-lactamase substrates, CCF2 and CCF4. These ... where cleavage by endogeneous cytoplasmic esterases ... charged forms, thereby trapping them in ...
Src cDNA Expression Kit (wild type)...
Biology Products: