Navigation Links
Large animal models of Huntington's disease offer new and promising research options
Date:4/22/2013

apeutics.

"Pigs, and mainly minipigs, represent a viable model for preclinical drug trials and long-term safety studies," says Jan Motlik, DVM, PhD, DSc, from the Laboratory of Cell Regeneration and Plasticity of the Institute of Animal Physiology and Genetics in Libechov, Czech Republic. Advantages include its large brain size and long lifespan. Genetic advances have been made, including defining the porcine genome, with a 96% similarity between the porcine and human huntingtin genes. In addition to well-established methods for pig husbandry, they are economical to house and have body systems very similar to that of humans.

In the report by Baxa et al., a new HD minipig model using lentiviral infection of porcine embryos is described. The authors report that they successfully developed a heterozygote transgenic HD minipig that expresses a human mutant HTT fragment throughout the CNS and peripheral tissues through 4 successive generations. The model produces viable offspring, with a total neonatal mortality rate of 17%. The authors reported that one affected HD minipig showed a decline beginning at 16 months of a neuronal phosphoprotein, DARPP32, in the neostriatum, the brain region most affected by HD. A loss of fertility, possibly HD related, was also found.


'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
3. Size matters: Large Marine Protected Areas work for dolphins
4. Large international study finds memory in adults impacted by versions of 4 genes
5. Scientists provide first large-scale estimate of reef shark losses in the Pacific Ocean
6. Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
7. UI professor identifies largest known crocodile
8. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
9. Nottingham researchers lead worlds largest study into pre-eclampsia
10. Could cap and trade for water solve problems facing the United States largest rivers?
11. Bay Area PV Consortium announces $7.5 million in grants to lower the cost of large-scale solar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... points is a straight line, and now Harvard researchers ... axiom to heart. , Though competition among individual ... racing for the chance to fertilize the egg, Harvard ... that allow them to take a straighter path to ... Heidi Fisher, a post-doctoral student working in the lab ...
(Date:7/30/2014)... A group of researchers from the University of Helsinki ... experimentally to reproduce in mice morphological changes which have ... gradual modifications in the embryonic development of mice teeth, ... morphologically are very similar to those observed in the ... millions of years ago. , To modify the ...
(Date:7/30/2014)... Press (OUP) is pleased to announce its new relationship ... 2015, OUP and CINP will partner to publish ... a fully open-access journal. , Alan Frazer, Editor-in-Chief of ... size and expertise of OUP will further facilitate the ... of the very leading journals within neuropsychopharmacology. The conversion ...
Breaking Biology News(10 mins):When cooperation counts 2When cooperation counts 3Scientists reproduce evolutionary changes by manipulating embryonic development of mice 2OUP to partner with the International College of Neuropsychopharmacology 2
... CITY, Aug. 31, 2009 Researchers at Huntsman Cancer Institute ... on Ewing,s sarcoma, an often deadly bone cancer that typically ... with poor outcomes have tumors with high levels of a ... chemotherapy. The research is published online today in the journal ...
... its usefulness in counting copies of duplicated genome sequences and ... study to be published Aug. 30 in Nature Genetics ... differ from one person to the next. The researchers ... Search Tool. The study is titled, "Personalized Copy Number and ...
... on the neural mechanisms involved in social behavior, neuroscientists ... the brain structure responsible for our sense of personal ... 30 issue of the journal Nature Neuroscience , ... social distance is an issue. The structure, the ...
Cached Biology News:New hope for deadly childhood bone cancer 2Counting duplicated genome segments now possible 2Counting duplicated genome segments now possible 3Caltech neuroscientists find brain region responsible for our sense of personal space 2Caltech neuroscientists find brain region responsible for our sense of personal space 3Caltech neuroscientists find brain region responsible for our sense of personal space 4
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
(Date:7/30/2014)... MD (PRWEB) July 30, 2014 ... today the release of the REVELERIS® Prep ... organic chemists, preparative chromatographers, and other researchers to ... using a single unit. , With the REVELERIS® ... flash and preparative chromatography modes with a simple ...
(Date:7/30/2014)... July 30, 2014  Replikins Ltd. today released new ... Ebola virus. Before the current outbreaks, the mean Ebola ... amino acids) between 1995 and 2002 was 1.1; the ... 2012, and sixteen-fold in 2013, thus predicting the current ... technology has been shown to be able to predict ...
(Date:7/30/2014)... 2014   Wyle has been named ... Mission Support Services (FILMSS) contract awarded by the ... terms of the contract, Wyle will provide mission ... Calif. In particular, Wyle will provide program and ... on the International Space Station and collaborative science ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Grace Launches New REVELERIS® Prep Purification System 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2
... traditional August break, the Senate may help decide the future ... hope a scientifically sound and ethical resolution is reached - ... ,Just as Republicans in the Wisconsin Legislature are divided over ... President Bush suffered a rare political defeat in May when ...
... crazy? , ,Theres a question that every technology entrepreneur ... families, friends, employees, customers and, yes, investors. When youre ... that new-to-the-world and must-have tech breakthrough, your sanity will ... even more interesting than the question is how tech ...
... Waukesha, Wis. - ProHealth Care , a ... deployed an application delivery system from NetScaler, Inc. ... the system to better coordinate application usage and response ... and two regional hospitals, 13 primary care clinics, home ...
Cached Biology Technology:Stem cell debate in Washington grows hotter as summer recess nears 2Stem cell debate in Washington grows hotter as summer recess nears 3Psychologist - technology entrepreneurs frequently experience hypomania 2Psychologist - technology entrepreneurs frequently experience hypomania 3
...
... PlusOne Silver Staining Kit, Protein, 1. ... and Dernick (1), the kit gives ... electrophoresis systems.Silver Staining Kit, Protein provides ... proteins in polyacrylamide gels in less ...
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Cyno macaque plasma and serum - various quantities available...
Biology Products: