Navigation Links
Large animal models of Huntington's disease offer new and promising research options
Date:4/22/2013

changes. There are also important anatomic differences between the brains of humans and rodents that become especially relevant when studying HD, including the lack of a gyrencephalic (convoluted) cortex and differences in the structure and cellular characteristics of the basal ganglia compared to humans. Not only does a rodent's small brain often preclude the use of advanced neuroimaging techniques, it is also not clear how intracerebral application of trophic factors, transplant therapies, and gene therapies in small animals might translate to the much larger human brain.

"Importantly, the brains of large animals can be studied using sensitive measures that should be highly translatable to the human condition, including MRI and PET imaging, EEG, and electrophysiology, as well as behavioral tests looking at motor and cognitive function," says Professor Jenny Morton, PhD, of the Department of Physiology, Development and Neuroscience at the University of Cambridge. "Moving to larger-brained animal models after promising results are obtained in rodents is a logical, and possibly necessary, step to optimize delivery and biodistribution, validating on-target mechanism of action, and assessing safety profiles," says Professor Morton

"Strategies directed against the huntingtin gene in the brain are an important part of CHDI's therapeutic portfolio", says David Howland, PhD, Director of Model Systems at CHDI. "Translating preclinical results for gene-based therapies from rodent models to larger-brained models of HD is an important step along the path toward clinical testing."

Significant advances have been made in the creation and characterization of HD models in nonhuman primates (NHP). "The relevance to human biology of NHP models in Huntington's disease hold great potential value for preclinical research and development, but we need to fully consider the substantial issues of cost, long-term housing of affected animals, access of the model
'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
3. Size matters: Large Marine Protected Areas work for dolphins
4. Large international study finds memory in adults impacted by versions of 4 genes
5. Scientists provide first large-scale estimate of reef shark losses in the Pacific Ocean
6. Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
7. UI professor identifies largest known crocodile
8. Aware Provides Biometrics Software and Services for Three Large-Scale Border Management Systems
9. Nottingham researchers lead worlds largest study into pre-eclampsia
10. Could cap and trade for water solve problems facing the United States largest rivers?
11. Bay Area PV Consortium announces $7.5 million in grants to lower the cost of large-scale solar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... Utah , June 26, 2015 ATL Technology, ... and devices with specialties in single use solutions, headquartered in ... of MedConx, Inc. (a California corporation ... and San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility ...
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., ... patent by the United States Patent and Trademark Office ... This process leverages TAKE Solutions, Clinical Accelerators to reduce ... 50% (when compared to standardization without the accelerators), thus ... At the heart of the ...
(Date:6/24/2015)... SAN JOSE, Calif. , June 24, 2015 ... leading developer of human interface solutions, today announced ... fingerprint sensor to provide secure authentication for its ... Having recently reached more than 200 million shipments ... shipment with Sharp reinforces Synaptics, strength, scalability and ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2TAKE Solutions Awarded Patent By USPTO 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... for Microbiology (ASM) Abbott Laboratories Award in Clinical ... Rosenberg, Chief of Surgery, National Cancer Institute, Professor ... Sciences, and Professor of Surgery, George Washington University ... Abbott Laboratories Diagnostics Division, this award recognizes a ...
... (NCRR), a part of the National Institutes of ... $33.3 million for 20 High-End Instrumentation (HEI) grants ... equipment. Awarded to research institutions nationwide, these one-time ... equipment costing more than $750,000, offer extraordinary potential ...
... 28, 2008The 2008 American Society for Microbiology (ASM) ... Van Brakle, Microbiology Laboratory Supervisor, Walter Reed Army ... outstanding, bench-level clinical microbiologist. Ms. Van Brakle ... Walter Reed for the past 16 years, the ...
Cached Biology News:American Society for Microbiology honors Steven A. Rosenberg 2NIH awards more than $33 million to fund state-of-the-art research equipment 2NIH awards more than $33 million to fund state-of-the-art research equipment 3American Society for Microbiology honors Regina S. Van Brakle 2
(Date:7/3/2015)... 3, 2015  Pomerantz LLP announces that a class ... ("Puma" or the "Company")(NYSE: PBYI ) and certain ... States District Court, Central District of California ... of a class consisting of all persons or entities ... May 13, 2015 inclusive (the "Class Period").  This class ...
(Date:7/2/2015)... (PRWEB) , ... July 03, 2015 , ... Cuvettes have been used in countless labs ... catalog to find the cuvette they needed. As expected, this was a daunting and ... the wrong part because they were not able to navigate the complex catalog structure. , ...
(Date:7/2/2015)... , July 2, 2015  Spherix Incorporated (Nasdaq: ... fostering and monetization of intellectual property, today announced a ... Spherix Incorporated v. Verizon Services Corp. et al. , ... for the Eastern District of Virginia ... 1, 2015 interpreting certain key claims in favor of ...
(Date:7/2/2015)... ... July 02, 2015 , ... Sleepless nights will become obsolete ... of sleep, launched its Indiegogo campaign on June 23. Sound sleepers and the sleep ... makes it effortless to use, while the integration of the Bluetooth speaker, alarm clock ...
Breaking Biology Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4New Cuvette E-Commerce Website Launched by FireflySci 2Spherix Issues A Litigation Update 2Spherix Issues A Litigation Update 3Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3
... MaxCyte, Inc., the pioneer,in scalable, high performance ... the MaxCyte STX Scalable Transfection System at the ... Innovations,in Reagents, Technology, and Screening," to be held ... October 23-24, 2008. In addition, MaxCyte will,sponsor the ...
... MITI ), a biopharmaceutical company developing novel, ... autoimmune,diseases, today announced that it will host a ... 2008, at 9:00 am Eastern Time (3:00 pm,Central ... financial results.,Micromet anticipates releasing its financial results at ...
... DIEGO, Oct. 22 Halozyme Therapeutics,Inc. (Nasdaq: HALO ... extracellular matrix, today,announced that it will present at three ... be held at the Hyatt Regency in La,Jolla, Calif. ... (5:00 p.m. EDT);, -- Oppenheimer,s 19th Annual Healthcare ...
Cached Biology Technology:The MaxCyte STX Scalable Transfection System to be Launched at the SBS Symposium on Cell-Based Assays 2Micromet, Inc. to Host Conference Call and Webcast to Discuss Third Quarter 2008 Financial Results 2Micromet, Inc. to Host Conference Call and Webcast to Discuss Third Quarter 2008 Financial Results 3Micromet, Inc. to Host Conference Call and Webcast to Discuss Third Quarter 2008 Financial Results 4Halozyme Therapeutics to Present at Upcoming Investor Conferences 2