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Landon Foundation-AACR INNOVATOR Awards
Date:4/11/2008

ns are essential to addressing the cancer problem on a global scale. To ensure continued progress in conquering cancer, researchers must be willing to share resources and technologies, lend expertise and communicate new concepts, perspectives and methodologies to the worldwide cancer community, said Foti. The work of Dr. Carbone and his team illustrates a commitment to all of these goals and it is a pleasure to recognize him and his team by providing much needed support for promising research that spans two continents.

Carbone and his team of international collaborators have discovered a unique mesothelioma epidemic in three Turkish villages and have demonstrated that it is caused by a genetic predisposition to mineral fiber carcinogenesis, a gene-environment interaction. Mesothelioma is a form of cancer where malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Carbone and colleagues have identified exposure to erionite as the likely cause of the epidemic and have reduced exposure to that mineral fiber throughout the villages. They will apply the AACR INNOVATOR grant to their study of linkage analysis to identify the predisposing gene or genes for mesothelioma among this cultural group and map the genetic risk factors by genetic linkage studies. Findings from this research have implications far beyond the villages in Turkey as they can be applied to other geographic areas and communities worldwide with the goal of preventing this deadly form of cancer or finding new life-saving treatments.

Honorees will receive their awards during the Opening Ceremony of the AACR Annual Meeting on Sunday, April 13, 2008 at 8:15 a.m. in Hall G-H of the San Diego Convention Center. For complete award citations, biographies and photos of award winners, contact Jennifer Ryan in the AACR Department of Communications and Public Relations: 267-646-0558; jenn
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Contact: Jennifer Ryan
jennifer.ryan@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

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