Navigation Links
Landmark study opens door to new cancer, aging treatments
Date:8/31/2008

(PHILADELPHIA)Researchers at The Wistar Institute have deciphered the structure of the active region of telomerase, an enzyme that plays a major role in the development of nearly all human cancers. The landmark achievement opens the door to the creation of new, broadly effective cancer drugs, as well as anti-aging therapies.

Researchers have attempted for more than a decade to find drugs that shut down telomerasewidely considered the No. 1 target for the development of new cancer treatmentsbut have been hampered in large part by a lack of knowledge of the enzyme's structure.

The findings, published online August 31 in Nature, should help researchers in their efforts to design effective telomerase inhibitors, says Emmanuel Skordalakes, Ph.D., assistant professor in Wistar's Gene Expression and Regulation Program, who led the study.

"Telomerase is an ideal target for chemotherapy because it is active in almost all human tumors, but inactive in most normal cells," Skordalakes says. "That means a drug that deactivates telomerase would likely work against all cancers, with few side effects."

The study elucidates the active region of telomerase and provides the first full-length view of the telomerase molecule's critical protein component. It reveals surprising details, at the atomic level, of the enzyme's configuration and how it works to replicate the ends of chromosomesa process critical to both tumor development and the aging process.

Achieving immortality

In humans, telomerase adds multiple repeats of a short DNA sequence to the ends of chromosomes, known as telomeres, thus preventing damage and the loss of genetic information during cell division.

When telomerase is dormant, telomeres shorten each time a cell divides, leading eventually to genetic instability and cell death. By preserving chromosomes' integrity, telomerase allows cells to continue living and dividing. The enzyme is a
'/>"/>

Contact: Abbey J. Porter
aporter@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Childrens national co-leads nationwide study of landmark sickle cell treatment
2. Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
3. SAGE and Hindawi announce landmark open access agreement
4. Safeway Inc. and PCF to fund landmark prostate cancer research collaboration
5. Study shows more genes are controlled by biological clocks
6. Armored fish study helps strengthen Darwins natural selection theory
7. Study says eyes evolved for X-Ray vision
8. Study of islands reveals surprising extinction results
9. Study points to potential new use for Viagra
10. Unique study shows oil, gas seismic work not affecting Gulf sperm whales
11. ETH Zurich study on salmonella self-destruction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the addition ... report to their offering. , The primary ... is who she/he is claiming to be, and for this ... physical characteristics, such as fingerprint, hand or palm print, iris, ...
(Date:1/22/2015)... 13, 2015 Technology Showcase, Hall E -   EyeLock ... today announced it will showcase its EyeLock ID technology integrated ... Department of Energy,s Oak Ridge National Laboratory (ORNL) ... EyeLock,s iris identity authentication technology is being used to validate ...
(Date:1/22/2015)... ROBERTS, Washington , January 20, 2015 ... and tech stocks, releases video from the CES 2015 (Consumer ... consultant Apollo Robbins . Apollo shows how ... biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... show that regular use of popular prescription pain relievers may ... percent and may offer similar benefit in the prevention of ... were released today at the annual meeting of the American ... believe this is the first study to show that selective ...
... migrate north for the summer, the faster they put ... who has been tracking migrating birds for several years. ... protected areas which will ensure birds can complete their ... research on Tuesday 4th April at the Society for ...
... that promise to remove wrinkles and other effects of ... really work? , Vanderbilt University Medical Center investigators have ... aging in the skin that could be used to ... February issue of the Journal of Investigative Dermatology. , ...
Cached Biology News:COX-2 inhibitors significantly reduce risk of cancer 2Biomarkers may hone anti-aging therapies 2
(Date:2/27/2015)... Immunovaccine Inc. (“Immunovaccine”) (TSX: IMV), ... announced that the U.S. Food and Drug Administration ... and Phase I clinical trials of the DPX-Anthrax ... co-development agreement signed with Gilead Life Sciences. The ... the DPX-Survivac. , “We have been in talks ...
(Date:2/27/2015)... Australia , Feb. 27, 2015 Bionomics ... from the DisrupTOR-1 trial of BNC105 in patients with ... in Orlando, Florida . The data ... of the City of Hope Comprehensive Cancer Center in ... The new data identifies Ferritin and ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 FamilyFarms Group ... General Manager of State Line Farms, received the 2015 ... a producer, under the age of 35, who has ... is an honor to win the Tomorrow's Top Producer ... who won the Top Producer Award and learning from ...
(Date:2/27/2015)... BERKELEY, Calif. , Feb. 27, 2015  Steep ... in the US and internationally, intends to open a ... Albuquerque, New Mexico , bringing advanced scientific ... of cannabis. Steep Hill is currently the ... Health to conduct potency and contaminant testing in order ...
Breaking Biology Technology:Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 2Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2
... RESEARCH TRIANGLE PARK, N.C., July 1 ... fellowship,program to help postdoctoral scientists from the state,s ... NCBC Industrial Fellowship Program will retain home-grown research,talent ... It is designed to fill a gap for ...
... Ill., July 1 Healthation, a healthcare,technology ... large Canadian Third,Party Administrator (TPA) to a ... use,the integrated real-time, rules-based AcceleHealth(R) benefits and ... deliver interactive,self-service capabilities across its medical, dental, ...
... ORLANDO, Fla., July 1 Galaxy Nutritional,Foods, Inc. (OTC ... alternatives, organic dairy and other organic and natural food,products, ... year ended March 31, 2008. The Company will host ... a.m. Eastern Time (EDT),today, July 1, 2008 (see details ...
Cached Biology Technology:N.C. Biotechnology Center Launches Industrial Fellowship Program 2N.C. Biotechnology Center Launches Industrial Fellowship Program 3Healthation Chosen by Large Canadian Third Party Administrator to Support All Employee Benefits and Claims Administration 2Galaxy Nutritional Foods Reports FY2008 Results 2Galaxy Nutritional Foods Reports FY2008 Results 3Galaxy Nutritional Foods Reports FY2008 Results 4Galaxy Nutritional Foods Reports FY2008 Results 5Galaxy Nutritional Foods Reports FY2008 Results 6Galaxy Nutritional Foods Reports FY2008 Results 7Galaxy Nutritional Foods Reports FY2008 Results 8Galaxy Nutritional Foods Reports FY2008 Results 9
... Plus accurately and conveniently controls the temperature at ... different temperature levels up to 99 C*, with ... as low as 5 C. The thermoblocks for ... tubes, and microplates enable a high degree of ...
... developed to significantly increase the shelf life ... is increased at room temperature storage conditions ... product is subjected to 0.2 micron filtration, ... This formulation insures consistently high levels of ...
...
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
Biology Products: