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Landmark study describes prostate cancer metastasis switch
Date:4/2/2013

pelling picture of SPDEF working in part through the modulation of E-Cadherin to inhibit prostate cancer metastasis," Koul says. "To the best of our knowledge these are the first studies demonstrating the requirement of SPDEF for expression of E-Cadherin."

Koul says that his group is getting very close to turning off the loss of E-Cadherin in cancer cells by re-arming tumors with the gene that makes SPDEF and my testing small molecules that increase SPDEF in cancer cells.

"This could be a real landmark," Koul says. "We see a prerequisite for metastasis and now we have a very clear picture of how to remove this necessary condition for the most dangerous behavior of prostate cancer."


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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