Navigation Links
Lampreys provide hints to ancient immune cells
Date:8/12/2013

Studying lampreys allows biologists to envision the evolutionary past, because they represent an early offshoot of the evolutionary tree, before sharks and fish.

Despite their inconspicuous appearance, lampreys have a sophisticated immune system with three types of white blood cell that resemble our B and T cells, researchers have discovered.

Scientists at Emory University School of Medicine and the Max Planck Institute of Immunology and Epigenetics in Freiburg have identified a type of white blood cell in lampreys analogous to the "gamma delta T cells" found in mammals, birds and fish. Gamma delta T cells have specialized roles defending the integrity of the skin and intestines, among other functions.

The results are published in the journal Nature.

The finding follows an earlier study showing that cells resembling two main types of white blood cells, B cells and T cells, are present in lampreys. In the human immune system, B cells can differentiate into antibody-secreting cells and can grab their targets directly, while T cells generally recognize their targets only through cell-to-cell contact.

"We have been able to define another lineage of T-like lymphocytes in lampreys," says first author Masayuki Hirano, PhD, assistant professor of pathology and laboratory medicine at Emory University School of Medicine and the Emory Vaccine Center. "This suggests that the genetic programs for all three lineages of white blood cells are very ancient."

Hirano says the team's results indicate that distinct cells with functions that are similar to gamma delta T cells may have existed in the last common vertebrate ancestor, before jawed and jawless vertebrates diverged around 500 million years ago.

The senior author of the paper is Max Cooper, MD, professor of pathology and laboratory medicine at Emory University School of Medicine and the Emory Vaccine Center, and a Georgia Research Alliance Eminent Schol
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. New insights into neuroblastoma tumor suppressor may provide clues for improved treatment
2. Lets have lunch! -- teachers eating with their students provides nutrition education opportunities
3. New technologies and ingredients provide better options for gluten-free eating
4. Genomic atlas of gene switches in plants provides roadmap for crop research
5. Protected areas provide African birds with stepping stones to survival
6. Biometric Authentication Provides Better Mobile Device Security, Heavy Reading Finds
7. The duck genome provides new insight into fighting bird flu
8. New research shows that potatoes provide one of the best nutritional values per penny
9. Schools should provide opportunities for 60 minutes of daily physical activity to all students
10. Schools should provide students with daily physical activity, IOM recommends
11. Study provides insight into nesting behavior of dinosaurs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Calif. , April 20, 2015 Huntington ... Gabriel Valley to implant a new miniaturized, wireless monitoring ... System is the first and only FDA-approved heart failure ... hospital admissions when used by physicians to manage heart ... sensor that is implanted in the pulmonary artery (PA) ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... bed in Alberta has helped map out the animal's life ... species lived, says new research conducted in part at the ... was that the overall pattern of survivorship fits closer to ... expecting," said world-renowned paleontologist Dr. Phillip Currie and professor in ...
... cancer may play a role in resistance to therapeutic effects ... May 17 Journal of the National Cancer Institute. ... family of proteins involved in many cell functions, such as ... have suggested that the presence of this protein may lead ...
... responsible for singing and mating are shrinking when exposed to ... first proof that natural exposure to a contaminant damages the ... been persisting since the late 1960s--that's what is really disturbing," ... U of A's Department of Psychology. "It has been years ...
Cached Biology News:Tyrannosaur survivorship -- tough times for teens 2Pak1 expression increases tamoxifen resistance in breast cancer patients 2Bird brains shrink from exposure to contaminants 2
(Date:5/5/2015)... Washington, and WASHINGTON, D.C., USA (PRWEB) May 05, 2015 ... on U.S. export regulations covering a wide range of ... industry say are hampering global competitiveness of U.S. industry. ... host a webinar on 12 May on ... XII, which governs the commodities covered by International Traffic ...
(Date:5/5/2015)... , May 5, 2015 CytomX, a ... cancer, today announced that Sean McCarthy , D. ... Suisse Antibody Day in New York ... Dr. McCarthy will present an overview of CytomX,s Probody ... drug conjugate programs. About CytomX Therapeutics ...
(Date:5/5/2015)... College Station, TX (PRWEB) May 05, 2015 ... Pfizer were announced last week as recipients of ... Technology Innovation in recognition of their Portable, Continuous, ... system that integrates a small footprint, continuous processing ... GMP modules) to process API powders and inactive ...
(Date:5/4/2015)... , May 4, 2015 Many of ... But for certain infants with rare, inherited mutations ... stark consequences of their impaired immune responses. ... have identified an important role for calcium signaling ... Mycobacterium tuberculosis, the bacterium causing tuberculosis (TB). ...
Breaking Biology Technology:Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3Researchers Discover A Novel And Unexpected Role For Calcium In Controlling Inflammation During Chronic Lung Infection 2Researchers Discover A Novel And Unexpected Role For Calcium In Controlling Inflammation During Chronic Lung Infection 3
... Array of Healthcare Products to ... Deficiency and Bleeding Disorders, OTTAWA, April 3, ... Canadian Blood Services, and Hema-Quebec, have each awarded,the ... Humate(R) P (Antihemophilic factor / von Willebrand Factor,Complex ...
... April 3 A majority of the Israeli,scientists, in ... special methods that could "put them into a creative ... as desired." Sponsored by the,Jerusalem-based Project Mind Foundation and ... when the issue of risk was raised,one fifth of ...
... CEO Honors the Anniversary by Ringing The Closing Bell(R) at ... ... 3, 2008 Edwards,Lifesciences Corporation (NYSE: EW ), a world ... its,50th anniversary of partnering with clinicians to develop life-saving,innovations. To celebrate ...
Cached Biology Technology:CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 2CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 3CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 4CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 5CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 6CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 7CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies 8Project Mind Survey of Israeli Ph.D. Scientists Favors a New Standard of Creativity in Science 2Project Mind Survey of Israeli Ph.D. Scientists Favors a New Standard of Creativity in Science 3Edwards Lifesciences Celebrates 50 Years of Life-Saving Innovations 2Edwards Lifesciences Celebrates 50 Years of Life-Saving Innovations 3
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Edited by I.H. Pawlowitzki, J.H. Edwards and E.A. Thompson (1997) • This volume covers: Linkage in dominant recessive and oligogenic disease, Model free (non-parametric) methods, Tools for gene ...
Biology Products: