Navigation Links
Laminin builds the neuromuscular synapse

Like a plug and a socket, a nerve and a muscle fiber mesh at the neuromuscular junction. New work by Nishimune et al published in the Journal of Cell Biology reveals that an extracellular matrix protein called laminin shapes both sides of the junction to ensure they fit together type="rel"doi="10.1083/jcb.2008.

A neuromuscular junction, or synapse, in a newborn mouse is functional but simple, with a globular nerve terminal meeting a flat, oval structure on the muscle fiber. As the animal matures, the nerve terminal branches into a claw shape, and the muscle side contorts into a matching conformation. But what coordinates these changes so the two sides mirror each other? The researchers think that one molecule in the synapse sculpts both sides.

Their chief suspect was the synapse-spanning protein laminin. Made by muscle and forming part of the sheath that covers muscle, the laminin protein has different domains called alpha, beta, and gamma chains. Previous work had shown that the beta2 chain of laminin spurs differentiation of the nerve terminal. The team has now found evidence that the alpha chains of laminin influence post-synaptic patterning. For example, maturation of the muscle side slowed in mice lacking the alpha5 chain of laminin in their muscles.

The researchers discovered that cell surface receptor molecules that recognize and bind laminin, are corralled by laminin on the muscle side of the synapse. These receptors, in turn, gather other receptors that respond to signals from the nerve. Overall, the work suggests that the beta and alpha chains of laminin together influence pre-synaptic and post-synaptic development, thus providing a way to coordinate maturation of the sending and receiving sides of the synapse.


Contact: Sati Motieram
Rockefeller University Press

Page: 1

Related biology news :

1. GM, Coskata partnership builds on Oklahoma State University biofuels research
2. New approach builds better proteins inside a computer
3. A key enzyme helps keep the synapse on track
4. Breakthrough technology observes synapse in real time, supporting theory of vesicular recycling
Post Your Comments:
(Date:11/12/2015)...  Arxspan has entered into an agreement with ... use of its ArxLab cloud-based suite of biological ... will support the institute,s efforts to electronically manage ... internally and with external collaborators. The ArxLab suite ... Institute,s electronic laboratory notebook, compound and assay registration, ...
(Date:11/10/2015)... About signature verification Signature ... identify and verify the identity of an individual ... secure and accurate method of authentication and is ... because each individual,s signature is highly unique. Signature ... signature of an individual is compared and matched ...
(Date:11/2/2015)... , Nov. 2, 2015  SRI International has been ... provide preclinical development services to the National Cancer Institute ... will provide scientific expertise, modern testing and support facilities, ... preclinical pharmacology and toxicology studies to evaluate potential cancer ... The PREVENT Cancer Drug Development Program is an ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 Orexigen® Therapeutics, ... will participate in a fireside chat discussion at the ... New York . The discussion is scheduled for ... .  A replay will be available ... Contact:McDavid Stilwell  , Julie NormartVP, Corporate Communications and ...
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association (USGA) ... USGA Green Section Award. Presented annually since 1961, the USGA Green Section Award recognizes ... with turfgrass. , Clarke, of Iselin, N.J., is an extension specialist of ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper ... unless it is bound to proteins, copper is also toxic to cells. With ... Worcester Polytechnic Institute (WPI) will conduct a systematic study of copper in the ...
(Date:11/24/2015)... PUNE, India , November 24, 2015 ... to a new market research report "Oligonucleotide Synthesis Market ... Equipment), Application (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User ... to 2020", published by MarketsandMarkets, the market is expected ... 1,078.1 Million in 2015, at a CAGR of 10.1% ...
Breaking Biology Technology: