Navigation Links
Laminin builds the neuromuscular synapse
Date:9/14/2008

Like a plug and a socket, a nerve and a muscle fiber mesh at the neuromuscular junction. New work by Nishimune et al published in the Journal of Cell Biology reveals that an extracellular matrix protein called laminin shapes both sides of the junction to ensure they fit together type="rel"doi="10.1083/jcb.2008.

A neuromuscular junction, or synapse, in a newborn mouse is functional but simple, with a globular nerve terminal meeting a flat, oval structure on the muscle fiber. As the animal matures, the nerve terminal branches into a claw shape, and the muscle side contorts into a matching conformation. But what coordinates these changes so the two sides mirror each other? The researchers think that one molecule in the synapse sculpts both sides.

Their chief suspect was the synapse-spanning protein laminin. Made by muscle and forming part of the sheath that covers muscle, the laminin protein has different domains called alpha, beta, and gamma chains. Previous work had shown that the beta2 chain of laminin spurs differentiation of the nerve terminal. The team has now found evidence that the alpha chains of laminin influence post-synaptic patterning. For example, maturation of the muscle side slowed in mice lacking the alpha5 chain of laminin in their muscles.

The researchers discovered that cell surface receptor molecules that recognize and bind laminin, are corralled by laminin on the muscle side of the synapse. These receptors, in turn, gather other receptors that respond to signals from the nerve. Overall, the work suggests that the beta and alpha chains of laminin together influence pre-synaptic and post-synaptic development, thus providing a way to coordinate maturation of the sending and receiving sides of the synapse.


'/>"/>

Contact: Sati Motieram
motierd@mail.rockefeller.edu
212-327-8581
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. GM, Coskata partnership builds on Oklahoma State University biofuels research
2. New approach builds better proteins inside a computer
3. A key enzyme helps keep the synapse on track
4. Breakthrough technology observes synapse in real time, supporting theory of vesicular recycling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
(Date:3/22/2017)... , March 21, 2017 ... Cloud used by retailers such as 1-800-Flowers and ... platform — Product Recommendations and Replenishment. Using Optimove,s machine ... more personalized product and replenishment recommendations to their ... also on predictions of customer intent drawn from ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel visited ... to the DERMALOG stand together with the Japanese Prime Minster Shinzo Abe. ... the largest German biometrics company the two government leaders could see the ... well as DERMALOG´s multi-biometrics system.   Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... , ... LABS, Inc. (LABS) announced in December 2016 that two new ... Acid Testing (NAT) for ZIKV; and Enzyme Immunoassays (EIAs) specific for IgM and IgG ... blood donors under an Investigational New Drug (IND) study protocol. , Now, as ...
(Date:4/26/2017)... RESTON, Va. (PRWEB) , ... April 26, 2017 ... ... to make headlines and drive high-level conversations among healthcare industry stakeholders, the discussion ... Healthcare Environment – taking place May 15-18, 2017 in Los Angeles, Calif. Hosted ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... supplier of Common Lisp (CL) development tools, and market leader for Semantic ... key performance enhancements now available within the most effective system for developing and ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... Medicine & Rehabilitation, P.A. , proudly announced today that acclaimed physiatrist Matthew Terzella, ... duties on May 15, 2017. , Dr. Terzella completed his residency in Physical ...
Breaking Biology Technology: