Navigation Links
Lack of vitamin D contributes to pain in black Americans with knee osteoarthritis
Date:11/6/2012

A new study reveals that black Americans display lower levels of vitamin D and greater pain sensitivity compared to white Americans. Findings published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), indicate that vitamin D deficiency may be one of many factors that account for increased pain in older black Americans with knee osteoarthritis (OA).

Those with OA experience painful swelling and stiffness of the joints such as knees, hips and fingers. The National Arthritis Data Workgroup estimates that 27 million Americans over 25 years of age have OA (based on 2005 U.S. census data). A long-term study by researchers from the University of North Carolinathe Johnston County OA Projectsuggests that lifetime risk of developing knee OA is roughly 46%.

During the last decade medical evidence has uncovered the importance of vitamin D, not only as a vitamin that aids in calcium absorption, but as a powerful hormone with numerous functions throughout the body. In fact, studies have found that a decreased vitamin D level reduces immunity and may contribute to diseases such as cancer and diabetes.

Most vitamin D in humans comes from exposure to the sun, with research suggesting that a deficiency of this important vitamin may be due to more indoor activities, increased sunscreen use, and need for longer sun exposure for those with dark skin pigmentation. One study estimates that 95% of black Americans compared to 70% of white Americans have low levels of vitamin D.

"People associate vitamin D with good bone health," said lead author Toni Glover, MSN, ARNP, a research nurse practitioner and doctoral candidate at the University of Florida, specializing in the study of pain in older adults. "Yet, not everyone is aware of what factors decrease vitamin D and how low levels could contribute to health issues, including chronic pain."

Clinical practice guidelines state that vitamin D levels less than 20 ng/mL represent deficiency and levels between 21 and 29 ng/mL represent insufficiency. Given that low levels of vitamin are linked to chronic pain and other health conditions, especially in black Americans, the research team set out to investigate if variations in vitamin D levels contribute to racial differences in patients with knee pain caused by OA.

With funding from the National Institute on Aging and the John A. Hartford Foundation and the Mayday Fund, researchers at the University of Florida and the University of Alabama at Birmingham recruited 94 participants45 black and 49 white patients with symptomatic knee OAto complete questionnaires regarding their symptoms. The study group was 75% female and had an average age of 56 years.

In addition, study subjects underwent testing that included sensitivity to heat and mechanical pain on the affected knee and the forearm. Researchers measured heat pain threshold as the point when patients indicate the sensation "first becomes painful" and pain tolerance when patients "no longer feel able to tolerate the pain." Mechanical pain measures were determined by the patients' response to pressure in the knee and forearm.

Despite living in a southern sunny climate, findings indicate that 84% of black participants had vitamin D levels less than 30 ng/mL compared to 51% of white subjects. Furthermore, the average vitamin D level for black Americans was 19.9 ng/mL (deficiency), compared to white Americans who averaged 28.2 ng/mL (insufficiency). Black participants reported greater overall knee osteoarthritis pain and those with lower vitamin D levels displayed greater sensitivity to heat and mechanical pain (experimental pain).

"Our data demonstrate that differences in experimental pain sensitivity between the two races are mediated at least in part by variations in vitamin D levels," concludes Ms. Glover. "However, further studies are needed to fully understand the link between low vitamin D levels and racial disparities in pain. Although rare, vitamin D toxicity is possible and older adults should consult with their primary care provider regarding supplementation. It may be warranted that older black Americans with chronic widespread pain be screened for vitamin D deficiency to reduce disparities in pain." The authors plan to pursue additional research which tests the impact of improving vitamin D status on chronic pain for older black and white Americans.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related biology news :

1. Daily multivitamin use does not reduce cardiovascular disease risk in men
2. Vitamin C and beta-carotene might protect against dementia
3. Vitamin D supplements do not improve cholesterol as previous research suggested
4. High doses of Vitamin D help tuberculosis patients recover more quickly
5. Vitamin B12 deficiency: Tracing the causes
6. Vitamin B12 deficiency: Tracking the genetic causes
7. Vitamin D supplementation can decrease risk of respiratory infections in children
8. Iron, vitamins could affect physical fitness in adolescents
9. Lower vitamin D could increase risk of dying, especially for frail, older adults
10. Scientists confirm existence of vitamin deserts in the ocean
11. Obesity plus low vitamin D may add up to a greater risk of diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ) ... "Global Facial Recognition Market 2016-2020" report ... ) has announced the addition of the ... report to their offering. --> ... announced the addition of the "Global ...
(Date:2/3/2016)... 3, 2016 --> ... report "Automated Fingerprint Identification System Market by Component (Hardware ... (Banking & Finance, Government, Healthcare, and Transportation) and Geography ... market is expected to be worth USD 8.49 Billion ... 2015 and 2020. The transformation and technology evolution from ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 ... healthcare facilities are primarily focused on medical ... that measure point-of-care parameters. Wearable devices that ... a user,s freedom of movement are being ... sensors for human biomedical signal acquisition coupled ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) ... December 31, 2015. --> --> ... net loss of $29.3 million, or $0.34 loss per share, compared ... share for the same period in 2014. For the year ended ... million, or $1.05 loss per share, as compared to a net ...
(Date:2/11/2016)... ATLANTA , Feb. 11, 2016  Spectra BioPharma ... Organization (CSO) that provides biopharma companies the experience, ... implement and deploy outsourced sales teams. Created in ... team addresses both the strategic and tactical needs ... innovative sales solutions through both personal and non-personal ...
(Date:2/11/2016)... 2016 --> ... (OTCQB: PSID), a life sciences company focused on ... subsidiary, which markets the Caregiver® FDA-cleared non-contact thermometer, ... January 2016, including entering into agreements with five ... growth, and establishing several near-term pipeline opportunities. ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
Breaking Biology Technology: