Navigation Links
Lack of protein FKBP51 in old mice improves resilience to depressive behavior
Date:9/16/2011

d that slight variations in the FKBP5 gene are associated with increased susceptibility to psychiatric disorders, including depression, post-traumatic stress disorder and anxiety.

The researchers decided to examine for the first time whether old mice without the FKBP5 gene (and its protein by-product) were more resistant to depression using behavioral tests that routinely evaluate antidepressant effectiveness. They exposed two groups of old mice (17 to 20 months) to activities designed to induce depressive/stressed behavior. One group was FKBP5 deficient, while the other (littermates) was not.

"We wondered if the FKBP5-deficient mice would demonstrate more resilience, or greater antidepressant behavior, in response to the tests," said lead author John O'Leary, a PhD student in neuroscience at the USF Health Byrd Alzheimer's Institute.

They did, and without any apparent adverse consequences. The FKBP5-deficient mice performed as well as their littermates with the FKBP5 gene intact on tasks designed to test memory, learning and basic motor functions.

In an experiment coinciding with the observed effects on depression, the researchers discovered that corticosterone levels rose as expected in both the FKBP5-deficient mice and their non-deficient counterparts following a stressful activity. However, the amount of corticosterone circulating in the blood of the FKBP5-deficient mice was still lower than that measured in the non-FKBP5 mice. Corticosterone (known as cortisol in humans) is a steroid hormone released in response to stress and its levels are higher than normal in depressed patients.

The researchers suggest that the lack of the protein FKBP51 leads to a decrease in HPA-axis activities, including a weakening of stress hormones, which may improve resilience to depression.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Health)
Source:Eurekalert

Page: 1 2

Related biology news :

1. ORNL invention unravels mystery of protein folding
2. Protein found in heart may be target for colon cancer therapies
3. USC scientists identify key protein linked to acute liver failure
4. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
5. Scientists find new drug candidates for set of protein-folding diseases
6. Foods rich in protein, dairy products help dieters preserve muscle and lose belly fat: study
7. Research offers new way to target shape-shifting proteins
8. Molecular chaperones traffic signaling proteins between cells in plant stem-cell maintenance pathway
9. Degrading proteins to divide cells
10. Protein in the urine spells kidney failure for African-Americans
11. Single protein, key to ebola virus infection, could aid in drug design
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... -- Unisys Corporation,s (NYSE: UIS ) subsidiary in ... that it has been selected by the Dutch Custodial Institutions ... Provision Biometrics solution for penitentiaries across The Netherlands ... a solution based on its open standards-based LEIDA ... is up to seven years, with the new system expected ...
(Date:7/10/2014)... DALLAS , July 3, 2014 ... Sensors Market by Type (Swipe And Area), Material (Optical ... Defense, Healthcare, Commercial Security and Banking & Finance), and ... 2020", published by MarketsandMarkets, the global Fingerprint Sensors Market ... at a high CAGR of 16.8% from 2014 to ...
(Date:7/10/2014)... York , July 7, 2014 ... Transparency Market Research "Electronic Access Control Systems Market Global ... - 2019," the global Electronic Access Control systems market ... is expected to grow at a CAGR of 12.6% ... of USD 31,187.8 million in 2019. Browse ...
Breaking Biology News(10 mins):Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5
... from the Walter and Eliza Hall Institute in Melbourne, ... Society, the UK,s peak academy promoting excellence in science. ... inducted to the Royal Society in 2011, including four ... review process on the basis of excellence in science. ...
... Polarstern of the Alfred Wegener Institute for Polar and ... at its homeport of Bremerhaven after a seven-month expedition ... in 15 countries took part in the expedition. The ... the water in the deep Weddell Sea continues further. ...
... David Cleveland, a professor of environmental studies at UC Santa ... a great example of what many are advocating as a ... a local food system. Santa Barbara County ranks in ... in value of agricultural products, with 80 percent of that ...
Cached Biology News:Top Australian malaria researcher elected Fellow of the Royal Society 2Top Australian malaria researcher elected Fellow of the Royal Society 3Research ship Polarstern returns from Antartica 2Research ship Polarstern returns from Antartica 3UCSB localizing fruit, vegetable consumption doesn't solve environmental, health issues 2UCSB localizing fruit, vegetable consumption doesn't solve environmental, health issues 3
(Date:7/10/2014)... fight against terrorism with the creation of a sensor ... use of light and special glass fibres. , Published ... , the researchers describe a novel optical fibre sensor ... 6.3 ppm (parts per million). It requires an analysis ... detection has involved looking for metals that encase them ...
(Date:7/10/2014)... today in the journal PNAS (Proceedings of the ... of day and sleep deprivation have a significant effect ... looking at the best time of day to test ... for administering medicines effectively. , Researchers from the University ... investigated the links between sleep deprivation, body clock disruption ...
(Date:7/10/2014)... fractional quantum Hall effect in bilayer graphene and shown ... by an electric field. , The fractional quantum ... thin sheets are exposed to large magnetic fields, is ... individual electrons behave as a single system. However, while ... many details of this collective behavior remain not well ...
(Date:7/10/2014)... geckos and spiders can sit upside down forever. Nanophysics makes ... this in an article just published in Physical Review ... , Geckos and spiders that seem to be able to ... researchers worldwide for many years. We will soon be able ... as the gecko,s foot. But the fact is, sooner or ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2
... Batey, Ph.D.2 , and Brendan Bohannan, Ph.D.1 , ... , , ... , Abstract , ... to measure the ammonia-oxidizing bacteria (AOB) population in soils maintained under 16 environmental regimes.,DNA was ...
... , AquaPure Genomic DNA Isolation ... range: 100300 g DNA, , Method ... 1. Use fresh blood within 10 sec of venipuncture to avoid clotting. Alternatively, , ... reduce , DNA degradation. Blood may be either fresh or frozen. ...
... , , , ... gel support frame, used with the Trans-Blot , ... from agarose gels to nylon membrane in minutes, without any gel pretreatments. , ... generates a , high field strength (V/cm 2 ...
Cached Biology Technology:Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 2Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 3Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 4Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 5Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 6Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System 7Genomic DNA Isolation Protocol for 40 l Avian Whole Blood 2DNA/RNA Blotting With the Trans-Blot SD Semi-Dry Electrophoretic Transfer Cell 2
... the premium quality siRNAs you need for ... be readily ordered online by providing either ... providing the sense and antisense siRNA sequences. ... Validated and Silencer Pre-designed siRNAs, ...
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
... HT, 1 kit. Facilitates the simple, phenol-free ... and hard tissue requiring proteinase K digestion.Each ... DNA from 50 preparations of up to ... Synthesis & Purification, Purification and Amplification of ...
Biology Products: