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Lack of naturally occuring protein linked to dementia
Date:8/26/2014

o communicate with each other, leading to alterations in the ability to acquire new memories.

"Deterioration of brain function commonly occurs as we get older but, as result of dementia or other neurodegenerative diseases, it can occur earlier in people's lives", says Dr Corra. "For those who develop the early signs of dementia it becomes more difficult for them to adapt to changes in their life, including performing routine tasks.

"For example, washing the dishes; if you have washed them by hand your whole life and then buy a dishwasher it can be difficult for those people who are older or have dementia to acquire the new memories necessary to learn how to use the machine and mentally replace the old method of washing dishes with the new. The change in shape of the postsynaptic neuron due to absence of MK2/3 is strongly correlated with this inability to acquire the new memories".

Dr Corra argues that "Given their vital role in memory formation, MK2/3 pathways are important potential pharmaceutical targets for the treatment of cognitive deficits associated with ageing and dementia."


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Contact: Tom Frew
a.t.frew@warwick.ac.uk
44-024-765-75910
University of Warwick
Source:Eurekalert  

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