Navigation Links
Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
Date:6/23/2009

A lack of serotonin, commonly known as the "happiness hormone", in the brain slows the growth of mice after birth and is responsible for impaired maternal behavior later in life. This was the result of research conducted by Dr. Natalia Alenina, Dana Kikic, and Professor Michael Bader of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany. At the same time, the researchers discovered that the presence of serotonin in the brain is not crucial for the survival of the animals. Furthermore, they were able to confirm that there are two strictly separate pathways of serotonin production: One gene is responsible for the formation of serotonin in the brain, another gene for the production of the hormone in the body (PNAS, June 23, 2009, Vol. 106, No. 25, pp 10332-10337)*.

The researchers "switched off" the gene Tph2 in mice to elucidate the function of the gene in the brain. Tph2 produces the enzyme tryptophan hydroxylase (TPH), which is responsible for the formation of serotonin.

After the researchers switched off Tph2, the animals produced almost no serotonin in the brain. Nevertheless, the animals were viable and half of them survived until adulthood. However, they needed more sleep during the day and the regulation of their respiration, body temperature, and blood pressure was altered.

The female mice were able to give birth and produced enough milk to feed their pups, but their impaired maternal behavior led to poor survival of the offspring.

The Tph2 gene was discovered by MDC researchers several years ago together with researchers of the Free University (FU) Berlin and Humboldt University Berlin (HUB).


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1

Related biology news :

1. Can happiness be inherited?
2. Network science for eternal happiness and good business
3. Fatty foods -- not empty stomach -- fire up hunger hormone
4. Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
5. Pregnancy hormone predicts postpartum depression
6. Protein that regulates hormones critical to womens health found in pituitary
7. Hormone therapy associated with reduced colorectal cancer risk
8. Food can affect a cell in the same way hormones do
9. Children distressed by family fighting have higher stress hormones
10. Apelin hormone injections powerfully lower blood sugar
11. Birth control has long-term effect on hormone exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... engineers, led by Clemson University associate professor Brian ... from the U.S. Department of Energy,s Experimental Program ... positive impact on South Carolina in the advancement ... , "Understanding the scientific and engineering needs for ... nuclear technologies is imperative if South Carolina is ...
(Date:9/30/2014)... and farm runoff in Hawaii is causing tumors in ... The study, published Tuesday in the peer-reviewed open-access journal ... ends up in algae that the turtles eat, promoting ... and internal organs. , Scientists at Duke University, the ... Administration (NOAA) conducted the study to better understand the ...
(Date:9/30/2014)... available in German . ... response to risky situations such as exposure to predators. ... found in a long-term study on different populations of ... rate and ambient temperature. High metabolic rates and low ... these scenarios birds were more likely to approach potential ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2
... Despite dozens of interceptions at U.S. ports, a public enemy ... N.Y., and identified by a Cornell University expert, the adult ... discovered in the eastern United States. , The discovery of ... woodwasp, raises red flags across the nation because the invasive ...
... study in the April issue (currently available online) ... take scientists closer to understanding how cells in ... Researchers, led by Anthony Firulli, Ph.D., associate professor ... at the Indiana University School of Medicine, investigated ...
... to happen - you being in a car wreck or being ... greater killers win a free trip to the beach. It's really ... being in a wreck are far greater than being a shark's ... who has studied sharks for years. , Worldwide, about one million ...
Cached Biology News:Alien woodwasp, threat to US pine trees, found in N.Y. 2Determining The Fate Of Cells In The Human Body 2New HIV drug candidate developed in Sweden 2
(Date:10/1/2014)... TeselaGen Biotechnology has received ... expand their bioCAD/CAM software suite, which uses synthetic ... Small Business Innovation Research Phase II grant will be ... license from the Lawrence Berkeley National Laboratory. j5 was ... LBNL laboratory that develops alternative fuel technologies for the ...
(Date:10/1/2014)... 30, 2014 This report analyzes ... US$ Million by the following Product Segments: ... Specific end-use segments also analyzed are Pharmaceuticals ... The report provides separate comprehensive analytics for ... East, and Latin America. Annual estimates and ...
(Date:9/30/2014)... release is available in German . ... around several quantum dots in a semiconductor layer. Quantum dots ... of atomic processes. If a short laser pulse is fired ... the quantum dot experiences a change in the electromagnetic field ... the emission of light by the dot. As soon as ...
(Date:9/30/2014)... German . , ... demonstrated a new kind of building block for digital ... could be based on three-dimensional arrangements of nanometer-scale magnets ... the semiconductor industry CMOS fabrication of silicon chips ... at the University of Notre Dame are exploring "magnetic ...
Breaking Biology Technology:TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Ultrafast remote switching of light emission 2A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3
... SEATTLE, March 8, 2011 Cell Therapeutics, Inc. (CTI) ... present at the Bio Europe Spring 2011 Conference on ... 1, room Yellow 2, at Milano Convention Centre, Milan, ... PM CET /10:30 AM EST/ 7.30 AM PSTRoom Yellow ...
... NEW YORK, March 7, 2011 Reportlinker.com ... is available in its catalogue: ... strategic assessment of the competitive environment is ... priority management responsibilities, the task crucial to ...
... Reportlinker.com announces that a new market ... The 2011 Blood Banking ... and Business Expansion Strategies for Suppliers ... During the next ten years, the blood ...
Cached Biology Technology:Reportlinker Adds The 2011 Top Ten World's Leading Life Science Intermediates Companies 2Reportlinker Adds The 2011 Blood Banking Market: US, Europe, Japan - Emerging Opportunities and Business Expansion Strategies for Suppliers 2