Navigation Links
Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
Date:6/23/2009

A lack of serotonin, commonly known as the "happiness hormone", in the brain slows the growth of mice after birth and is responsible for impaired maternal behavior later in life. This was the result of research conducted by Dr. Natalia Alenina, Dana Kikic, and Professor Michael Bader of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany. At the same time, the researchers discovered that the presence of serotonin in the brain is not crucial for the survival of the animals. Furthermore, they were able to confirm that there are two strictly separate pathways of serotonin production: One gene is responsible for the formation of serotonin in the brain, another gene for the production of the hormone in the body (PNAS, June 23, 2009, Vol. 106, No. 25, pp 10332-10337)*.

The researchers "switched off" the gene Tph2 in mice to elucidate the function of the gene in the brain. Tph2 produces the enzyme tryptophan hydroxylase (TPH), which is responsible for the formation of serotonin.

After the researchers switched off Tph2, the animals produced almost no serotonin in the brain. Nevertheless, the animals were viable and half of them survived until adulthood. However, they needed more sleep during the day and the regulation of their respiration, body temperature, and blood pressure was altered.

The female mice were able to give birth and produced enough milk to feed their pups, but their impaired maternal behavior led to poor survival of the offspring.

The Tph2 gene was discovered by MDC researchers several years ago together with researchers of the Free University (FU) Berlin and Humboldt University Berlin (HUB).


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1

Related biology news :

1. Can happiness be inherited?
2. Network science for eternal happiness and good business
3. Fatty foods -- not empty stomach -- fire up hunger hormone
4. Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
5. Pregnancy hormone predicts postpartum depression
6. Protein that regulates hormones critical to womens health found in pituitary
7. Hormone therapy associated with reduced colorectal cancer risk
8. Food can affect a cell in the same way hormones do
9. Children distressed by family fighting have higher stress hormones
10. Apelin hormone injections powerfully lower blood sugar
11. Birth control has long-term effect on hormone exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014  The second annual Biometrics UnPlugged Executive ... Tampa, Florida on September 15, 2014, ... Technology and Strategy at Samsung, and Philippe de ... of this year,s event is Mobility at the ... "Biometrics UnPlugged: Mobility at the Crossroads of Commerce ...
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
(Date:8/19/2014)... purchased at retail seafood counters in 10 different ... expose consumers to unexpectedly high levels of mercury, ... present a fish of the same species, but ... mislabeling offense, according to new research by University ... of seafood is essential to allow consumers to ...
Breaking Biology News(10 mins):Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3
... Infection control experts at The Johns Hopkins Hospital have ... a bleaching agent into the air and then detoxify ... preventing the spread of multiple-drug-resistant bacteria, or so-called hospital ... hydrogen peroxide vaporizers -- first deployed in several Singapore ...
... West China, Myanmar and Northern Vietnam contain one of the ... area are thousands of caves and gorges. It is only ... plants. This exploration is yielding many new species new to ... study was published in the open access journal ...
... Geosphere articles include additions to several special issues ... Change Offshore New Jersey"; "The ANDRILL McMurdo Ice Shelf (MIS) ... Sea and Beyond: Contributions to Marine Geology in Honor of ... the Colorado River System II." Topics include, 1. ...
Cached Biology News:Hydrogen peroxide vapor enhances hospital disinfection of superbugs 2Hydrogen peroxide vapor enhances hospital disinfection of superbugs 3Hydrogen peroxide vapor enhances hospital disinfection of superbugs 4Cave dwelling nettle discovered in China 2Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 2Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 3Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 4Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 5Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 6Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 7Geosphere covers Grand Canyon, deep drill coring, Death Valley, and more 8
(Date:8/19/2014)... Aug. 19, 2014   Synthetic Biologics, Inc. ... novel anti-infective biologic and drug programs targeting specific ... today that its novel C. difficile ... th Interscience Conference on Antimicrobial Agents and ... D.C. Synthetic Biologics, Senior ...
(Date:8/19/2014)... August 19, 2014 Sales Horizons, a ... its online sales skills training course to ... , MedTech clinical staff spend the majority of their ... standalone medical center, or physician practice – providing support ... why stop there? Sales Horizons believes clinical staff are ...
(Date:8/18/2014)... (Aug. 18, 2014) -- A new therapy developed ... (USF) Morsani College of Medicine and Columbia University ... complications of interventional cardiovascular disease treatment. , ... the novel molecular therapy could selectively inhibit blood ... a medical procedure using a balloon catheter to ...
(Date:8/18/2014)... Md. , Aug. 18, 2014 /PRNewswire/ ... maker of advanced consumer medical devices said ... was interviewed by CEOLIVE.TV as part ... The entire interview is available at ... Dr. Kotak explains to investors the unique ...
Breaking Biology Technology:Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3
... work 25 hours a day. So several speakers at the ... drive home the point that "work smarter, not harder" is ... of the University of Wisconsin-Madison School of Business, summed it ... Knetter said. To him, producing more by working more hours ...
... the possibility - make that probability - of data breaches are ... the CEO's top technologist doesn't mind consulting with the legal team, ... the message of attorney Erik Phelps, a partner in the law ... 2007 gathering that since e-mail is now discoverable in court, and ...
... sort - from the globally familiar to the local ... and venerated with a speed never seen before. The ... for brand commentary, both positive and negative, and these ... political brand managers. They now must proactively protect brand ...
Cached Biology Technology:Fusion 2007: Innovation drives productivity in post 24x7 world 2Fusion 2007: In e-legalities, CIOs and lawyers combine to provide business value 2Fusion 2007: In e-legalities, CIOs and lawyers combine to provide business value 3Brand protection in the age of customer engagement 2Brand protection in the age of customer engagement 3Brand protection in the age of customer engagement 4Brand protection in the age of customer engagement 5Brand protection in the age of customer engagement 6
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: