Navigation Links
Lack of 'gatekeeper' protein linked to skin cancer
Date:5/18/2011

New research from North Carolina State University shows that a "gatekeeper" protein plays an important role in skin-cancer prevention in humans and lab mice.

The protein, C/EBP alpha, is normally abundantly expressed to help protect skin cells from DNA damage when humans are exposed to sunlight. The NC State research shows, however, that the protein is not expressed when certain human skin cancers are present.

Moreover, when the protein is inactivated in special lab mice exposed to small amounts of the UVB solar radiation, the mice become more susceptible to skin cancer.

Dr. Robert Smart, professor of environmental and molecular toxicology at NC State and the corresponding author of a paper in the Journal of Investigative Dermatology describing the research, says that C/EBP alpha serves as an important "pause button" in cells. If there is any DNA damage, C/EBP alpha halts the cell-replication process to allow time for cells to repair themselves to prevent DNA errors from occurring.

"Loss of C/EBP alpha expression is associated with some of the most common human cancers, including breast and colon cancer," Smart says. "We think it may also have a role in tumor suppression in these cancers via its gatekeeper function."

In the study, the researchers found that human skin expresses C/EBP alpha as does the pre-cancerous, benign lesion called actinic keratose the precursor to skin cancer.

"C/EBP alpha is expressed in normal human skin and in pre-cancerous actinic keratoses, but something happens when cancerous lesions appear the protein is not expressed," Smart says. "We then asked, 'Is the loss of C/EBP alpha contributing to tumor formation?' The answer seems to be yes."

Smart and colleagues exposed hairless, genetically modified mice bred with C/EBP alpha inactivated to low doses of the UVB solar radiation. The mice were highly susceptible to certain common types of skin cancer squamous cell carcinomas with these cancerous tumors developing and growing rapidly.

"If you can figure out how to keep C/EBP alpha turned on, maybe the tumor would stay in its pre-cancerous state," Smart says.

Smart adds that figuring out how the protein fulfills its gatekeeper role and how and why the protein is inactivated in cancerous cells marks the next step in his research.


'/>"/>

Contact: Dr. Robert Smart
rcsmart@ncsu.edu
919-515-7245
North Carolina State University
Source:Eurekalert

Related biology news :

1. New path to water efficient seeds opens as TIP pips PIP as water gatekeeper
2. Protein could offer target to reduce lung damage from smoking-caused emphysema
3. UT Southwestern researchers find protein that might be key to cutting cancer cells blood supply
4. Researchers show heparan sulfate adjusts functions of growth factor proteins
5. Weizmann Institute scientists discover: A protein that contributes to obesity
6. Illinois professor chairs committee that recommends immediate calories, protein for TBI
7. Several baffling puzzles in protein molecular structure solved with new method
8. Discovery identifies elaborate G-protein network in plants
9. Researchers combine active proteins with material derived from fruit fly
10. Researchers get a first look at the mechanics of membrane proteins
11. Polarized microscopy technique shows new details of how proteins are arranged
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:4/28/2017)... ... ... Cynvenio Biosystems, Inc. a leader in personalized medicine technology and ... study in partnership with Allentown, PA-based TME Research . The multi-center registry study ... two years with Cynvenio’s ClearID Breast Cancer blood test. The study goal is to ...
(Date:4/27/2017)... Baltimore, MD (PRWEB) , ... April 27, 2017 ... ... analytics solutions provider for digital pathology, today announced their digital pathology technology has ... Using images provided by five medical centers in The Netherlands as part of ...
(Date:4/27/2017)... ... April 27, 2017 , ... ... flow controllers based on capillary thermal mass flow technology provide exponentially more accurate ... applications. Over 80% of all industrial processes—such as those involving chemical reactions, ...
(Date:4/27/2017)... a distinguished resource for research, development and commercialization of ... Thomas C. Seoh as President and CEO. Mr. Seoh ... becomes Executive Chairman and will continue to serve as ... Thomas Seoh commented, "I am excited and honored ... firm,s remarkable team of life science professionals, all of ...
Breaking Biology Technology: