Navigation Links
Laboratory detective work points to potential therapy for rare, drug-resistant cancer
Date:2/12/2014

responded to various concentrations of the 89 drugs in the laboratory, Dr. Duensing and her colleagues identified 37 compounds that showed some anticancer activity in at least one of the concentrations tested. Importantly, they noted that the most promising candidates all belonged to only two major drug classes: inhibitors of gene transcription and so-called topoisomerase II inhibitors. Based on these findings, the research team selected the two most promising compounds for further testing gene transcription inhibitor mithramycin A, which is in clinical trials to treat Ewing sarcoma, and topoisomerase II inhibitor mitoxantrone, which is used in metastatic breast cancer and leukemia.

Both drugs were highly effective in fighting GIST in laboratory tests. Moreover, the mechanism of action of each drug was linked to the specific underlying biology of these tumors.

"These are very encouraging results," said Dr. Duensing. "The next step will be moving our findings to clinical exploration to see if the results we found in the lab hold up in patients."


'/>"/>

Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology news :

1. From surgery to laboratory and back again
2. Story tips from the Department of Energys Oak Ridge National Laboratory, February 2014
3. Story tips from the Department of Energys Oak Ridge National Laboratory, January 2014
4. Official opening of wildlife health genetic and forensic laboratory between EcoHealth Alliance and Sabah Wildlife Department
5. New book on mouse models of cancer from Cold Spring Harbor Laboratory Press
6. New book on calcium techniques from Cold Spring Harbor Laboratory Press
7. New book on Signaling by Receptor Tyrosine Kinases by Cold Spring Harbor Laboratory Press
8. New manual from Cold Spring Harbor Laboratory Press on culturing neural cells
9. New eye treatment effective in laboratory tests
10. Medbox Partners with Licensed Medical Cannabis Laboratory and Cultivation Center in Canada
11. Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Laboratory detective work points to potential therapy for rare, drug-resistant cancer
(Date:7/31/2014)... biomass burning burning forests to create agricultural ... agriculture and wildfires figures into both climate ... release of a new study by Stanford University ... the degree of that contribution had never been ... paper published July 30 in the Journal ...
(Date:7/31/2014)... State University researchers have completed a 20-year study ... Hills prairie at different times of the year. ... late spring time frame has no measurable negative ... have multiple benefits. , The study was conducted ... Prairie Biological Station fire chief, and Joseph Craine, ...
(Date:7/31/2014)... Neb., July 31, 2014 -- Do people make a ... mothers raise them that way? Is it a matter ... Nebraska-Lincoln and a colleague from Rice University say that ... some people lean left while others lean right. , ... and deep-seated psychology are at the core of political ...
Breaking Biology News(10 mins):Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3Scientists find growing consensus: Political attitudes derive from body and mind 2
... research team has taken a major step forward in understanding ... immune response by combining nanotechnology and cell biology. T cells ... response to infection. Christopher Cairo and his team ... cell response is switched on. Cairo looked at the molecule ...
... of this campus activity is divided into three sessions: ... a patient,s perspective and embryology and ethics related to ... genetic counselors, molecular biologists, cytogeneticists, physicians, nurses, embryologists, patient ... find more information on this event here: http://www.eshre.eu/page.aspx/905 ...
... a molecular-scale version of ice fishing, a team of ... Technology (NIST) have developed methods to measure accurately the ... membranes. The "molecular rulers" they describe in a recent ... nanoporeswhose diameters on average are nearly 10,000 times smaller ...
Cached Biology News:U Alberta-led team studies T cell activation with nanoparticles 2Lollipops and ice fishing: Molecular rulers used to probe nanopores 2
(Date:8/1/2014)... August 01, 2014 Once a decision ... cost? This webinar will discuss how to define your ... Join speakers Bob Allen, Senior Director of Facilities Integration ... Engineering at Fluor Industrial Services, and special guest Carrier ... Planning at Amgen, as they provide an examination of ...
(Date:8/1/2014)... -- Cambrex Corporation (NYSE: CBM ) reports results ... Highlights , Second quarter sales increased 59% ... last year. , Second quarter EBITDA increased 86% to ... last year (see table at the end of this release). ... impact of foreign currency, to between 13% and 16% over ...
(Date:8/1/2014)... ON (PRWEB) August 01, 2014 ... has led to a better understanding embryonic development. ... and reorganize into structurally and functionally distinct tissues ... physical defects. Prof. Todd McDevitt, Melissa Kinney, ... biophysical signals interact with biochemical cues to control ...
(Date:7/31/2014)... August 01, 2014 “2014 ... Polyurethane Resin Industry” is a professional and ... The report introduces Polyurethane Resin basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
Breaking Biology Technology:Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Study Links Biomechanics and Gene Expression in Stem Cells 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4
... (Nasdaq: TARG ) today announced the pricing of ... stock at a price,to the public of $10.00 per ... Targanta has granted to the underwriters a 30-day option ... stock at the initial,offering price, less underwriting discounts and ...
... (NSH), a,leading owner and operator of surgical hospitals ... majority stake in Sterling Ridge Surgery,Center, a freestanding ... NSH acquired its share of the fully ... intends to convert the facility,into a surgical hospital ...
... No Water, Produces Pure Glycerin, CHICAGO and ... biodiesel refining and distribution company, announced today,that it ... a novel solid catalyst that converts low-grade fats ... be located in Seymour,Ind., eliminates the need for ...
Cached Biology Technology:Targanta Therapeutics Announces Pricing of its Initial Public Offering 2National Surgical Hospitals Acquires Majority Share of Houston-Area Surgery Center 2New Benefuel Refinery Targets Key Flaws in Biodiesel Production 2New Benefuel Refinery Targets Key Flaws in Biodiesel Production 3
UltraMount is formulated for coverslipping sections stained with alcohol soluble chromogens, such as Fast-Red or AEC. No heating is required prior to use. Coverslips may be removed by soaking in wate...
Agarose, Biotechnology grade, 500g...
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
... c-Jun proto-oncogene was first identified as the cellular ... Jun B and Jun D have been shown ... C-terminal regions, which are involved in dimerization and ... involved in transcriptional activation, diverge. ...
Biology Products: