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Lab tests show arthritis drug effective against global parasite
Date:5/20/2012

e, but would it work outside of a test tube? At UC San Diego, Reed's lab had developed a mouse model for amebiasis in the colon, which the parasite infects first, and in Mexico, researchers had developed a hamster model that showed the impact of amebiasis on the liver. In both tests, this was the most effective drug they had ever seen, markedly decreasing the number of parasites, damage from inflammation and the size of liver abscesses at a very low dosage.

With the much-coveted "proof of principle" in hand, Debnath wrote to the FDA for approval of auranofin for Orphan Drug Status an FDA program that fast-tracks new drugs that demonstrate promise in treating a neglected or orphan disease, defined as either fewer than 200,000 cases in the United States or those that are not expected to recover the costs of developing and marketing a treatment.

The team then worked with researchers at the Wake Forest School of Medicine to show that auranofin inhibits E. histolytica thioredoxin reductase an enzyme involved in defense against damage caused by oxygen metabolism making the parasite more susceptible to oxidative stress.


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Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

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