Navigation Links
Lab-on-a-chip homes in on how cancer cells break free
Date:3/18/2009

Johns Hopkins engineers have invented a method that could be used to help figure out how cancer cells break free from neighboring tissue, an "escape" that can spread the disease to other parts of the body. The new lab-on-a-chip, described in the March issue of the journal Nature Methods, could lead to better cancer therapies.

"Studying cell detachment at the subcellular level is critical to understanding the way cancer cells metastasize," says principal investigator Peter Searson, Reynolds Professor of Materials Science and Engineering. "Development of scientific methods to study cell detachment may guide us to prevent, limit or slow down the deadly spreading of cancer cells."

His team's research focuses on a missing puzzle piece in the common but unfortunate events that can occur in cancer patients. For example, cancer that starts in the breast sometimes spreads to the lungs.

That's because tumor cells detach and travel through the bloodstream to settle in other tissues. Scientists have learned much about how cancer cells attach to these surfaces, but they know little about how these insidious cells detach because no one had created a simple way to study the process.

Searson and two other scientists from Johns Hopkins' Whiting School of Engineering have solved this problem with a lab-on-a-chip device that can help researchers study cell detachment. With this device, they hope to discover exactly how cancer cells spread.

The lab-on-a-chip device consists of an array of gold lines on a glass slide. Molecules promoting the formation of cell attachments are tethered to the gold lines like balloons tied to string. A cell is placed on the chip, atop these molecules. The cell spreads across several of the gold lines, forming attachments to the surface of the chip with help from the molecules.

Then, the tethered molecules are released from one of the lines by a chemical reaction, specifically by "electro
'/>"/>

Contact: Mary Spiro
prs@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New holographic method could be used for lab-on-a-chip technologies
2. Fireproofing homes dramatically reduces forest fire size, according to new study
3. Increased allergen levels in homes linked to asthma
4. Newly described contaminant sources in Katrina-flooded homes pose health risks
5. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. ESF EURYI award winner aims to stop cancer cells reading their own DNA
8. Protein chatter linked to cancer activation
9. Newly created cancer stem cells could aid breast cancer research
10. Western diet linked to increased risk of colon cancer recurrence
11. Obesity and lack of exercise could enhance the risk of pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lab-on-a-chip homes in on how cancer cells break free
(Date:7/27/2015)... Calif. , July 27, 2015  Synaptics ... of human interface solutions, today announced that Huawei ... touchscreen solution for its stylish smartwatch. Huawei ... its proven reliability, low power and highly responsive ... wet finger. Huawei designers also required a classic ...
(Date:7/21/2015)... Connecticut , July 21, 2015  NXT-ID, ... "Company"), a biometric authentication company focused on the ... Wocket® smart wallet, announces that it has filed ... System and Method. This invention ... not only authorizes an account, but also the ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015  Synaptics ... interface solutions, announced today that it will report financial ... on Thursday, July 30, 2015 after the close of ... for analysts and investors at 2:00 p.m. PT (5:00 ...   To participate on the live call, ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2
... A team of researchers that includes a USC scientist ... more than the face per se are the key ... the common belief that brains process faces "holistically," appears this ... shedding light on the way the brain functions, these results ...
... the sensitivity of Greenland Ice Sheet outlet glaciers to rising ... bathymetry beneath them before accurate predictions of sea-level rise can ... body of sand on Earth, large enough to cover the ... of the oldest evidence of animals burrowing in search of ...
... death of the American Chestnut due to an Asian bark ... and economic consequences since the tree was highly valued for ... deer to birds to bears relied upon the chestnut for ... labor intensive and expensive, in part because they rely ...
Cached Biology News:New research about facial recognition turns common wisdom on its head 2Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 2Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 3Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 4Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 5Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 6Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 7Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 8Melting glaciers, enough sand to bury London, and ancient ecosystem engineering 9UC research tests new tool to guide reintroduction of the American chestnut 2UC research tests new tool to guide reintroduction of the American chestnut 3
(Date:7/29/2015)... , July 29, 2015  AsureQuality and ... molecular testing for applications in food and primary ... battery powered real-time PCR device, the Freedom4. ... right through to the supermarket shelf for producers, ... includes involvement in animal disease control and pest ...
(Date:7/29/2015)... Research and Markets ... the "Global Biosimilars Market, 2015 - 2025" ... Global Biosimilars Market, 2015 - 2025, report provides ... market. With the blockbuster biologics losing patent protection ... are being viewed as viable substitutes to the ...
(Date:7/29/2015)... -- AmnioChor Inc., an early stage biotech startup based on ... that the Musculoskeletal Transplant Foundation of Edison ... seed round of development of the proprietary AmnioCept™ product ... AmnioChor,s technology allows cryopreservation of the amniotic membrane ... within those tissues. Amnion is a well-established source of ...
(Date:7/29/2015)... , July 29, 2015  Pfenex Inc. (NYSE MKT: ... results will be released on Thursday, August 13, 2015, ... Time, Pfenex management will host a conference call to ... A press release outlining the financial results and business ... Please call 1-866-376-8058 (US) or 1-412-542-4131 (international) ...
Breaking Biology Technology:AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2
... Results: MIT electrical engineers have proposed a new ... high-resolution electron microscopes: they cannot be used to ... samples. The researchers suggest using a quantum mechanical ... remotely without ever hitting the imaged objects, thus ...
... ... contamination control products, introduces CapSure™ Technology, advancing the performance of cleanroom wipers on ... ... Corporation, a manufacturer of contamination control products for cleanroom and critical environments, introduces ...
... See for High-Paying Jobs and Economic Revitalization Across State ... Resources Defense Council (NRDC) will release a major new report ... energy jobs have to prove a major boost to farm ... With steady winds and ample access to the raw materials ...
Cached Biology Technology:Potential leap forward in electron microscopy 2New CapSure™ Cleanroom Wiper from Berkshire Corporation Captures and Retains 42 Times More Contaminant Particles 2A New Economic Future for Rural Indiana?: Study to Show How Renewable Energy Could Trigger Boom for Economically Struggling Areas in State 2
... that oxidative stress is involved in atherosclerosis, ... is the condition in which an imbalance ... leading to the damage of a cell. ... is through several antioxidant systems4 that include ...
... Micro Kit provides a fast and simple procedure ... and other detergents from small samples of protein. ... protein resin as an ion exchanger. Each column ... either acidic or basic protein.A complete kit for ...
... cells form from a hematopoietic stem cells ... to the bone surface and lowering the ... around 4.5. The bone mineral is then ... and function is controlled primarily by Macrophage ...
... Receptor-gamma (PPAR) is a member of ... transcription factors that heterodimerize with retinoic ... in the regulation of glucose and ... class of anti-diabetic agents called thiazolidinediones ...
Biology Products: