Navigation Links
Lab-on-a-chip homes in on how cancer cells break free
Date:3/18/2009

Johns Hopkins engineers have invented a method that could be used to help figure out how cancer cells break free from neighboring tissue, an "escape" that can spread the disease to other parts of the body. The new lab-on-a-chip, described in the March issue of the journal Nature Methods, could lead to better cancer therapies.

"Studying cell detachment at the subcellular level is critical to understanding the way cancer cells metastasize," says principal investigator Peter Searson, Reynolds Professor of Materials Science and Engineering. "Development of scientific methods to study cell detachment may guide us to prevent, limit or slow down the deadly spreading of cancer cells."

His team's research focuses on a missing puzzle piece in the common but unfortunate events that can occur in cancer patients. For example, cancer that starts in the breast sometimes spreads to the lungs.

That's because tumor cells detach and travel through the bloodstream to settle in other tissues. Scientists have learned much about how cancer cells attach to these surfaces, but they know little about how these insidious cells detach because no one had created a simple way to study the process.

Searson and two other scientists from Johns Hopkins' Whiting School of Engineering have solved this problem with a lab-on-a-chip device that can help researchers study cell detachment. With this device, they hope to discover exactly how cancer cells spread.

The lab-on-a-chip device consists of an array of gold lines on a glass slide. Molecules promoting the formation of cell attachments are tethered to the gold lines like balloons tied to string. A cell is placed on the chip, atop these molecules. The cell spreads across several of the gold lines, forming attachments to the surface of the chip with help from the molecules.

Then, the tethered molecules are released from one of the lines by a chemical reaction, specifically by "electro
'/>"/>

Contact: Mary Spiro
prs@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New holographic method could be used for lab-on-a-chip technologies
2. Fireproofing homes dramatically reduces forest fire size, according to new study
3. Increased allergen levels in homes linked to asthma
4. Newly described contaminant sources in Katrina-flooded homes pose health risks
5. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. ESF EURYI award winner aims to stop cancer cells reading their own DNA
8. Protein chatter linked to cancer activation
9. Newly created cancer stem cells could aid breast cancer research
10. Western diet linked to increased risk of colon cancer recurrence
11. Obesity and lack of exercise could enhance the risk of pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lab-on-a-chip homes in on how cancer cells break free
(Date:4/17/2014)... eight years ago, Katia Silvera , a postdoctoral scholar ... on a field trip in a mountainous area in central ... seen before. , Unable to identify it, they contacted German ... out to be an unnamed species. So Carnevali recently named ... is the genus name, comprising about 40 species in the ...
(Date:4/17/2014)... devastate honeybees in Europe, Asia and the United States ... to be impacting native honeybee populations at this time, ... pests include including Nosema microsporidia and ... be resilient to these invasive pests, which suggests to ... Europe, Asia and the United States currently are not ...
(Date:4/17/2014)... implicated in many serious conditions such as heart disease, ... for drug therapies. Unfortunately, there is still much scientists ... provides fresh and unexpected insight into the structure of ... β-subunit molecules - which are responsible for ,fine-tuning, the ... the most recent edition of the Journal of ...
Breaking Biology News(10 mins):Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Structure of sodium channels different than previously believed 2
... A University at Buffalo volcanologist, an expert in volcanic ash ... stream -- the area in the atmosphere that pilots prefer ... most likely to be impacted by plumes from volcanic ash. ... of the foremost experts on volcanic plumes and their effect ...
... species of dinosaur with a softball-sized lump of solid bone ... in the April issue of the journal Cretaceous Research ... as big as a medium-sized dog that lived 70 to ... lead author of the paper. The team discovered two skull ...
... take long for Binghamton University educational historian Adam Laats to ... in Wisconsin. "I was amazed at how nave I ... said Laats, now an assistant professor in Binghamton,s School of ... what was being taught in the classroom. Things I thought ...
Cached Biology News:Volcanic ash research shows how plumes end up in the jet stream 2New bony-skulled dinosaur species discovered in Texas 2Educational historian looks at origins of the culture wars 2Educational historian looks at origins of the culture wars 3
(Date:1/15/2014)... 2013 was a banner year of ... They saw continued independent research led by the team ... a $1 million grant from the Susanne Marcus Collins ... a peer reviewed journal, Amy Grant highlighted Brainwave Optimization® ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... PA (PRWEB) January 14, 2014 Date: Friday, ... , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... national nonprofit organization solely dedicated to finding a cure for ... affected worldwide, will host its annual Crystal Ball on Friday, ...
(Date:1/14/2014)... January 14, 2014 Histogen, Inc., a ... of cells grown under simulated embryonic conditions, today announced ... with Suneva Medical, Inc. for physician-dispensed aesthetic products containing ... , This agreement is an amendment to the existing ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... top line data from a Phase 2 clinical trial ... of Influenza-Like Illness (ILI) caused by all types and ... strains. In a double-blind, placebo-controlled, Phase 2 trial of ... DAS181 resulted in a significant reduction in patients, influenza ...
... (July 1, 2011) After Fukushima, it is now imperative ... from cradle to grave. If nuclear waste management is not ... will reject nuclear power as an energy choice, according to ... Atomic Scientists , published by SAGE. According to Allison ...
... just fifteen minutes to analyze a sample suspected of ... The technology amplifies any anthrax DNA present in the ... microscopic cells of the deadly bacteria Bacillus anthracis. ... lethal microbe that might be used intentionally to infect ...
Cached Biology Technology:NexBio Reports Safety and Significant Antiviral Activities of DAS181 (Fludase)* from a Dose-Ranging Phase II Clinical Trial 2NexBio Reports Safety and Significant Antiviral Activities of DAS181 (Fludase)* from a Dose-Ranging Phase II Clinical Trial 3NexBio Reports Safety and Significant Antiviral Activities of DAS181 (Fludase)* from a Dose-Ranging Phase II Clinical Trial 4Nuclear waste requires cradle-to-grave strategy 2Nuclear waste requires cradle-to-grave strategy 3Nano detector for deadly anthrax 2
... CLS number is a new product ... product number. If showing no availability ... Sigma-Aldrich number (C6671) or contact customer ... yes Surface area 148 cm 2 ...
BD BioCoat Fibronectin 150 mm Culture Dishes...
... Detection System is intended for use in ... by an in-house validated in vitro nucleic ... interest. • The ... hybridization capture assay designed to detect amplified ...
... uses include large-scale colony-counting and plaque-lifting, microbial ... TM automated colony picking and gridding ... product number, created to easily match Cornings ... please order under the old Sigma-Aldrich number ...
Biology Products: