Navigation Links
La Jolla Institute scientist leads team which discovers important new player in diabetes onset
Date:6/7/2010

th this study, we have discovered a new function for the ABCG1 protein. We now know that it is also very important for transport of cholesterol to various membranes within beta cells and, most likely, within other cells," she said. "Everybody thinks cholesterol is bad. But actually, scientists have long known it is an essential component of all cell membranes."

Dr. Hedrick and her team at the University of Virginia had heard of studies in diabetes mouse models showing that islet beta cells contained excessive cholesterol. "We wondered if this was somehow related to ABCG1, since its function is to remove excess cholesterol from the cells of the body," she said. "So we decided to investigate."

It was a novel idea, since ABCG1 was only known to sit on the plasma membrane of cells and no one had studied ABCG1 function within cells. "One surprising finding from our work is that ABCG1 action in beta cells is actually intracellular," said Dr. Sturek of the University of Virginia. "We found that the majority of ABCG1 actually sits inside the beta cell and that it's really important for delivering cholesterol intracellularly to the insulin granule membranes. Without delivery of cholesterol to these membranes by ABCG1, the insulin granules do not develop or function properly and, as a result, release significantly less insulin. This is particularly interesting because it suggests that we look at intracellular roles for ABCG1 in other cell types."

In previous studies, Dr Hedrick and her team had also made the finding that people with type 2 diabetes have relatively low levels of ABCG1. "We theorized that this contributed to higher rates of heart disease among type 2 diabetics since failure to successfully remove cholesterol from arteries can lead to arterial plaque buildup, a key contributor to heart disease."

Based on this latest research, Dr. Hedrick believes that boosting the levels of ABCG1 in diabetes patients may benefit sufferer
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Visionary concept earns La Jolla Institute scientist prestigious NIH Pioneer Award
2. La Jolla Institute discovers novel tumor suppressor
3. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
4. Harvards Wyss Institute uses natures design principles to create specialized nanofabrics
5. Rensselaer Polytechnic Institute professor Patrick Underhill receives NSF CAREER award
6. NOAA selects University of Miami to lead major southeastern US cooperative institute
7. Oklahoma Blood Institute to Leverage BIO-key(R) Breakthrough TruDonor(TM) Fingerprint Donor Identification
8. Rensselaer Polytechnic Institute wins $2.45 million grant to support stem cell research
9. Allen Institute for Brain Science launches Allen Human Brain Atlas
10. NYU Cancer Institute experts present at American Society of Clinical Oncology annual meeting
11. UM receives 5th consecutive Howard Hughes Medical Institute grant for science education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 22, 2015   EyeLock, Inc. , a ... has appointed Steve Gerber to the new role ... be responsible for leading development of mobile platforms and wearable ... of success and innovation in the semiconductor industry to his ...
(Date:12/22/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ... "The Global Watermarking and Fingerprinting Markets" report ... http://photos.prnewswire.com/prnh/20130307/600769 This insight provides an ... fingerprinting markets. Watermarking aims to control and monitor ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2The Global Watermarking and Fingerprinting Markets 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... medical device currently used for intestinal research, the colonsope, ... method has been developed, inspired by the way in ... received her PhD degree from TU Delft based on ... extremely difficult area to navigate through with a medical ...
... drug tamoxifen (Nolvadex®), which can become less effective over ... along with a second drug, according to new research ... Institute (NCI), part of the National Institutes of Health, ... 11, 2006, issue of Cancer Cell*. , Tamoxifen has ...
... Herceptin is borne by other patients whose treatment has to ... week’s BMJ. , New guidance from the National Institute for ... breast cancer, but it provides no extra funding and does ... extra money. This leaves medical staff with difficult decisions to ...
Cached Biology News:Like a snail through the intestinal canal 2Restoring tamoxifen sensitivity in resistant breast cancer cells 2Other patients bear the real cost of Herceptin 2
(Date:1/22/2015)... Pipette.com has added the Eppendorf Centrifuge ... of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 R ... R and receive the following:, ,     Free ... Eppendorf Reference 2 ,     3 Free boxes ...
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)... 22. 2015  Varian Medical Systems (NYSE: VAR ), ... for its commitment to sustainability with inclusion on a prestigious ... highest ranked healthcare equipment company among the Corporate Knights Global ... Economic Forum at Davos, Switzerland . ...
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... Tech provides veteran business leadership to deliver new ideas to market. ... ... www.lgeexecs.com [LGE Execs], an Austin based firm formed to ... agreement with the Texas Tech University System (TTUS). The agreement will ...
... - Dr. Yong Shi of Stevens Institute of ... his project titled "MEMS Umbrella-Shaped Actuator with Active ... on scientific/technical merit for three years and will ... is to design, fabricate and test an umbrella-shaped ...
... SAN FRANCISCO, Calif., Sept. 2 Anesiva,Inc. (Nasdaq: ... M.D. has joined,the company as senior vice president ... clinical and regulatory functions., "Bill brings to ... management products, and a medical background in,anesthesiology," said ...
Cached Biology Technology:LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences 2LGE Execs Teams with Texas Tech to License Advancements in Agriculture, Health and Life Sciences 3Dr. Yong Shi awarded NSF grant 2Anesiva Announces Appointment of William Houghton, M.D. as Senior Vice President and Chief Medical Officer 2
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... cell culture scale-up, these culture chambers produce ... 10 9 range and are useful ... flasks. • High mechanical • strength and ... to shipping • Certified nonpyrogenic and sterilized ...
Mouse monoclonal antibody to QARS - glutaminyl-tRNA synthetase...
... recombinant thermostable DNA polymerase obtained by high ... gene in E. coli, Concentration: 5U/ul, Applications: ... Fisher Scientific, the world leader in serving ... make the world healthier, cleaner and safer ...
Biology Products: