Navigation Links
La Jolla Institute scientist discovers key step in immune system-fueled inflammation
Date:7/1/2012

tream pursuing their infection-fighting duties. In order to accomplish their work, neutrophils must migrate through the blood vessel walls to sites of infection, injury or inflammation.

"The activities of neutrophils are very important for our survival, so they are the subject of significant scientific study," said Dr. Ley. While some scientists study their migration out of the blood vessel, Dr. Ley's lab has focused on how neutrophils adhere to the blood vessel wall. "This is important because it provides an opportunity to develop new treatments based on modulating or blocking one of the steps in the adhesion cascade," said Dr. Ley, noting that earlier studies have shown that blocking even one of the steps can severely reduce neutrophil recruitment.

While Dr. Ley has previously shown how neutrophils adhere when blood flow is slow, his latest study reveals that neutrophils use long membrane tethers at the front of the cell, termed "slings," to slow down during high blood flow. The cells do this by separating their cytoskeleton from the cellular membrane, wrapping the sling around themselves like a lasso and then digging their hooks into the blood vessel wall, said Dr. Ley. High blood flow occurs during inflammation, when the body rushes immune cells to a site to promote healing. Inflammation is a normal part of the healing process, but is unwanted in certain diseases.

"For these cells, adhering under high shear is like being in a huge wind storm," said Dr. Ley. "The challenge in this storm is not to get blown away."

Dr. Ley's studies could prove valuable in helping scientists understand how to reduce adhesion, where inflammation is unwanted, such as in heart or autoimmune disease, or to enhance the process, where more neutrophils are desired, such as in bacterial infections like MRSA. "The body needs to have enough neutrophils to fight off bacteria faster than they can grow," he said. "Better understanding of neutro
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
2. Diabetes Research Institute develops oxygen-generating biomaterial
3. Space research institute honors Sen. Hutchison with Pioneer Award
4. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
5. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
6. Cary Institute Hydrofracking Forum
7. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
8. Scripps Research Institute scientists develop antidote for cocaine overdose
9. NJIT, Chinas Bengbu Glass Institute sign agreement for R&D, training
10. Merkin Family Foundation to fund next generation of Broad Institute scientists
11. TGen leads new National Institutes of Health study of brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... PALM BEACH GARDENS, Fla. , June ... of multi-factor identity management and authentication solutions, today ... Altus strong, multi-factor authentication solution.  The ... ease of use of the DigitalPersona Altus ... and biometric reader compatibility. In ...
(Date:6/18/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market announces that its Wocket® smart wallet ... on the Mark", scheduled to air on WABC Radio (am770) ... th . The broadcast air- time for ... 8:00pm EST. NXT-ID, Inc.,s CEO Gino Pereira will ...
(Date:6/17/2015)... , and HILDEN, Germany , June ... QGEN ; Frankfurt Prime Standard: QIA) today launched new Investigator ... in forensic laboratories in the United States ... to simultaneously analyze multiple key genomic markers (short tandem repeats ... Quality Sensor to evaluate the quality of DNA in ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... Bethesda, MD FASEB MARC (Minority Access to ... for the 2011 American College of Sports Medicine (ACSM) ... 3-5, 2011. These awards are meant to promote the ... the mainstream of the basic science community and to ...
... the Deepwater Horizon rig in the Gulf of Mexico last ... and threatened Gulf ecosystems, the local Gulf Coast economy and ... at Rice University,s Baker Institute for Public Policy will examine ... scientific and technical information. The conference will feature academic scholars ...
... cell-based fluorescent assay they developed, scientists with the ... Laboratory (Berkeley Lab) and the University of California ... fluoxetine, the active ingredient in Prozac, suppresses the ... has been implicated in mood regulation and could ...
Cached Biology News:A second pathway for antidepressants 2A second pathway for antidepressants 3
(Date:7/6/2015)... 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), a company ... , Viveve,s Chief Executive Officer, and Scott Durbin , ... July 9, 2015. , , , DATE:    ... , , TIME:     , , , 12:15 PM ... , http://tinyurl.com/viveve   ,    ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... industry-leading products for use in applications such as animal waste reduction, bioremediation, ... plants and restaurant kitchen settings, announced today that it will be showcasing, ...
(Date:7/3/2015)... , July 3, 2015 ... till 22 september 2015 på  http://www.openinnovationinscience.at ... Innovation in Science" som hålls i ... en färsk undersökning med internationella forskare och ... (LBG) är hälsovetenskapens två största utmaningar bristen ...
(Date:7/2/2015)... , ... July 03, 2015 , ... Cuvettes have been used in countless labs for ... to find the cuvette they needed. As expected, this was a daunting and tiring ... wrong part because they were not able to navigate the complex catalog structure. , Now ...
Breaking Biology Technology:Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3New Cuvette E-Commerce Website Launched by FireflySci 2
... Report reveals robust investment in the industry; ... BOSTON, May 20 The global biotechnology industry,achieved ... 2007, as investors,and strategic partners showed strong confidence ... will continue to test the,industry in 2008. These ...
... Mass. -- May 19, 2008 -- Engineers ... demonstrated the first room-temperature electrically-pumped semiconductor source ... as T-rays. The breakthrough in laser technology, ... potential to become a standard Terahertz source ...
... Princeton University have created a new kind of ... mechanical properties, could be used in everything from ... nanocomposite that incorporates functionalized, exfoliated graphene sheets, even ... property to eventually create thermally stable, optically transparent ...
Cached Biology Technology:Record Venture Capital and Heated Deal Environment Propel Global Biotechnology Industry Forward in 2007 2Record Venture Capital and Heated Deal Environment Propel Global Biotechnology Industry Forward in 2007 3Record Venture Capital and Heated Deal Environment Propel Global Biotechnology Industry Forward in 2007 4Record Venture Capital and Heated Deal Environment Propel Global Biotechnology Industry Forward in 2007 5Engineers demonstrate first room-temperature semiconductor source of coherent Terahertz radiation 2By adding graphene, researchers create superior polymer 2